Abstract
Asthma is the most prevailing chronic inflammatory medical condition which is the outcome of extensive air pollution and which is associated with hyper-responsiveness of the respiratory system. Asthma causes excessive mucus production, blockage of air-passage, triggers inflammatory allergic responses, chronic lung infection, lifelong breathing troubles, and prolonged hospitalization in worst cases. Plant derived pollens may trigger asthmatic responses but on the other hand a number of medicinal plants and phytochemicals have been reported to ameliorate the symptoms associated with asthma. According to ethnomedicinal reports inhalation of certain kinds of herbs and administration of certain plant products could alleviate breathing and respiratory complexities. A number of animal model based studies have highlighted the role of plant extracts (PEs) and plant derived phytochemicals could alter the inflammatory responses by modulating the production of immunoglobulin E (IgE) and pro-inflammatory cytokine based immune signals. They could also suppress the accumulation of inflammatory cells which may lead to “hyper-drive” stage in respiratory system. Detailed analysis have highlighted the effective role of plant extracts and secondary metabolites modulating the release of TNF-α, IL-1β, IL-2, 4, 5, 6, 8, 13, IFN-γ, and other messenger molecules. Along with the experimental details and possible molecular mechanisms of the anti-asthmatic botanicals, this review also highlights constraints in medicinal plant oriented anti-asthmatic research, protocol based lacunae, details of toxicity and quality control studies and tries to link the traditional knowledge with laboratory-based findings.
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References
Bunyavanich S, Schadt EE (2015) Systems biology of asthma and allergic diseases: a multiscale approach. J Allergy Clin Immunol 135:31–42. https://doi.org/10.1089/ped.2014.0444
Chaudhari SP, Talele P (2014) Asthma management: a review. World J Pharm Res 3:275–326
DeChristopher LR, Uribarri J, Tucker KL (2016) Intakes of apple juice, fruit drinks and soda are associated with prevalent asthma in US children aged 2-9 years. Public Health Nutr 19:123–130. https://doi.org/10.1017/S1368980015000865
Raissy H, Blake K (2015) Vitamin D and asthma: association, causality, or intervention? Pediatr Allergy Immunol Pulmonol 28:60–62
Wong KO, Hunter Rowe B, Douwes J, Senthilselvan A (2013) Asthma and wheezing are associated with depression and anxiety in adults: an analysis from 54 countries. Pulm Med 2013:929028
Chronic Respiratory Disease Collaborators (2017) Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet Respir Med 5:691–706
Yu L, Wang B, Cheng M et al (2020) Association between indoor formaldehyde exposure and asthma: a systematic review and meta-analysis of observational studies. Indoor Air 30(4):682–690. https://doi.org/10.1111/ina.12657
Akmatov MK, Holstiege J, Steffen A et al (2020) Trends and regional distribution of outpatient claims for asthma, 2009–2016, Germany. Bull World Health Organ 98:40. https://doi.org/10.2471/BLT.19.229773
Chen Y, Dales R, Tang M et al (2002) Obesity may increase the incidence of asthma in women but not in men: longitudinal observations from the Canadian National Population Health Surveys. Am J Epidemiol 155:191–197. https://doi.org/10.1093/aje/155.3.191
Htet TD, Teede HJ, De Courten B et al (2017) Asthma in reproductive-aged women with polycystic ovary syndrome and association with obesity. Eur Respir J 49:1601334. https://doi.org/10.1183/13993003.01334-2016
Alem K, Gebeyehu S, Arega Y (2020) Risk factors and treatment types for asthma severity among adult patients. J Asthma Allergy 13:167. https://doi.org/10.2147/JAA.S246464
Arif AA, Rohrer JE, Delclos GL (2005) A population-based study of asthma, quality of life, and occupation among elderly Hispanic and non-Hispanic whites: a cross-sectional investigation. BMC Public Health 5:97. https://doi.org/10.1186/1471-2458-5-97
Vignola AM, Chanez P, Campbell AM et al (1998) Airway inflammation in mild intermittent and in persistent asthma. Am J Respir Crit Care Med 157:403–409. https://doi.org/10.1164/ajrccm.157.2.96-08040
Goyal BR, Agrawal BB, Goyal RK et al (2007) Pharmacological classification of herbal anti-asthmatics. Orient Pharm Exp Med 7:11–25
Bentley AM, Menz G, Storz CHR et al (1992) Identification of T lymphocytes, macrophages, and activated eosinophils in the bronchial mucosa in intrinsic asthma. Am Rev Respir Dis 146:500–506. https://doi.org/10.1164/ajrccm/146.2.500
Bousquet J, Chanez P, Lacoste JY, Barnéon G et al (1990) Eosinophilic inflammation in asthma. N Engl J Med 323:1033–1039. https://doi.org/10.1056/NEJM199010113231505
Djukanovic R, Wilson JW, Britten KM et al (1990) Quantitation of mast cells and eosinophils in the bronchial mucosa of symptomatic atopic asthmatics and healthy control subjects using immunohistochemistry. Am Rev Respir Dis 142:863–871. https://doi.org/10.1164/ajrccm/142.4.863
Pesci A, Foresi A, Bertorelli G et al (1993) Histochemical characteristics and degranulation of mast cells in epithelium and lamina propria of bronchial biopsies from asthmatic and normal subjects. Am Rev Respir Dis 147:684–689. https://doi.org/10.1164/ajrccm/147.3.684
Jeffery PK, Wardlaw AJ, Nelson FC et al (1989) Bronchial biopsies in asthma. Am Rev Respir Dis 140:1745–1753. https://doi.org/10.1164/ajrccm/140.6.1745
Singh SK, Patel JR, Dubey PK, Thakur S (2014) A review on antiasthmatic activity of traditional medicinal plants. Int J Pharm Sci Res 5:2095–2112. https://doi.org/10.13040/IJPSR.0975-8232.5(10).1000-07
Vikas S, Dhar KL, Pooja S, Parul S (2014) Indian herbal medicine - a natural cure to asthma. Int J Pharmacogn Phytochem Res 5:302–310
Adams BK, Cydulka RK (2003) Asthma evaluation and management. Emerg Med Clin N Am 21:315–330. https://doi.org/10.1016/s0733-8627(03)00015-4
Banner KH, Trevethick MA (2004) PDE4 inhibition: a novel approach for the treatment of inflammatory bowel disease. Trends Pharmacol Sci 25:430–436. https://doi.org/10.1016/j.tips.2004.06.008
Barnes PJ (2006) Drugs for asthma. Br J Pharmacol 147:297–303. https://doi.org/10.1038/sj.bjp.0706437
DiMartino SJ (2008) Idiopathic inflammatory myopathy: treatment options. Curr Rheumatol Rep 10:321–327. https://doi.org/10.1007/s11926-008-0051-4
Kesler SM, Sprenkle MD, David WS et al (2009) Severe weakness complicating status asthmaticus despite minimal duration of neuromuscular paralysis. Intensive Care Med 35:157–160. https://doi.org/10.1007/s00134-008-1267-5
Lugnier C (2006) Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents. Pharmacol Ther 109:366–398. https://doi.org/10.1111/j.1476-5381.2011.01729.x
Taur DJ, Patil RY (2012) Antihistaminic activity of Abrus precatorius using clonidine induced catalepsy in mice. Orient Pharm Exp Med 12(1):1–14
Goyal BR, Goyal RK, Mehta AA (2008) Beneficial effect of Achyranthes apsera Linn. In toluene-di-isocyanate induced occupational asthma in rats. Open Nat Prod J 1:44–49. https://doi.org/10.2174/1874848100801010044
Shukla A, Garg S, Garg A et al (2016) In vitro Achyranthes aspera evaluation of antiasthmatic activity of aerial parts. Asian J Pharm Pharmacol 2:128–131
Kumar D, Prasad DN, Parkash J et al (2009) Antiasthmatic activity of ethanolic extract of Aerva lanata Linn. Pharmacologyonline 2:1075–1081
Akah PA, Ezike AC, Nwafor SV et al (2003) Evaluation of the anti-asthmatic property of Asystasia gangetica leaf extracts. J Ethnopharmacol 89:25–36. https://doi.org/10.1016/S0378-8741(03)00227-7
Samiulla DS, Prashanth D, Amit A (2001) Mast cell stabilising activity of Bacopa monnieri. Fitoterapia 72:284–285. https://doi.org/10.1016/S0367-326X(00)00309-9
Singh B, Nadkarni JR, Vishwakarma RA et al (2012) The hydroalcoholic extract of Cassia alata (Linn.) leaves and its major compound rhein exhibits antiallergic activity via mast cell stabilization and lipoxygenase inhibition. J Ethnopharmacol 141:469–473. https://doi.org/10.1016/j.jep.2012.03.012
Kang SY, Park Y-K (2015) Effects of Agastachis herba extract on OVA-induced allergic asthma in mice. Korea J Herbol 30:1–12. https://doi.org/10.6116/kjh.2015.30.3.1
Xu W, Hu M, Zhang Q et al (2018) Effects of anthraquinones from Cassia occidentalis L. on ovalbumin-induced airways inflammation in a mouse model of allergic asthma. Elsevier Ireland Ltd, Shannon
Bhujbal SS, Nanda R, Ganu GP et al (2010) Protective effects of icosahydropicenic acid isolated from the roots of Clerodendrum serratum (L) moon on experimental allergic asthma. J Complement Integr Med 7:32. https://doi.org/10.2202/1553-3840.1401
Nageswari T, Ayesha K, Kumar B et al (2017) Evaluation of hydro alcoholic extract of Clerodendrum serratum leaf for anti-asthmatic activity. Int J Pharmacomet Integr Biosci 2:92–96
Sehgal R, Chauhan A, Gilhotra UK, Gilhotra A (2013) In vitro and in vivo evaluation of antiasthmatic activity of picrorhiza kurroa plant. Int J Pharm Sci Res 4:3440–3443. https://doi.org/10.13040/IJPSR.0975-8232.4(9).3440-43
Choudhary GP (2006) Mast cell stabilizing activity of Piper longum Linn. Indian J Allergy Asthma Immunol 20:112–116
Vadnere GP, Gaud RS, Singhai AK, Somani RS, (2009) Effect of Inula racemosa root extract on various aspects of asthma. Pharmacologyonline 2:84–94
Lee MY, Shin IS, Seo CS et al (2011) Antiasthmatic effects of Gleditsia sinensis in an ovalbumin-induced murine model of asthma. Int J Toxicol 30:528–537. https://doi.org/10.1177/1091581811412398
Dai Y, Chan YP, Chu LM, But PPH (2002) Antiallergic and anti-inflammatory properties of the ethanolic extract from Gleditsia sinensis. Biol Pharm Bull 25:1179–1182. https://doi.org/10.1248/bpb.25.1179
de Freitas Morel LJ, de Azevedo BC, Carmona F et al (2017) A standardized methanol extract of Eclipta prostrata (L.) L. (Asteraceae) reduces bronchial hyperresponsiveness and production of Th2 cytokines in a murine model of asthma. J Ethnopharmacol 198:226–234. https://doi.org/10.1016/j.jep.2016.12.008
Xia M, Liu L, Qiu R et al (2018) Anti-inflammatory and anxiolytic activities of Euphorbia hirta extract in neonatal asthmatic rats. AMB Express 8:179. https://doi.org/10.1186/s13568-018-0707-z
Taur DJ, Nirmal SA, Patil RY, Kharya MD (2007) Antistress and antiallergic effects of Ficus bengalensis bark in asthma. Nat Prod Res 21:1266–1270. https://doi.org/10.1080/14786410701757330
Rehman NU, Khan AU, Alkharfy KM, Gilani AH (2012) Pharmacological basis for the medicinal use of Lepidium sativum in airways disorders. Evidence-based Complement Altern Med 2012:596524. https://doi.org/10.1155/2012/596524
Tayade PM, Ghaisas MM, Jagtap SA, Dongre SH (2009) Anti-asthmatic activity of methanolic extract of leaves of Tamarindus Indica Linn. J Pharm Res 2:944–947
Kaushik D, Rani R, Kaushik P et al (2012) In vivo and in vitro antiasthmatic studies of plant Piper longum Linn. Int J Pharmacol 8:192–197. https://doi.org/10.3923/ijp.2012.192.197
Zemmouri H, Sekiou O, Ammar S et al (2017) Urtica dioica attenuates ovalbumin-induced inflammation and lipid peroxidation of lung tissues in rat asthma model. Pharm Biol 55:1561–1568. https://doi.org/10.1080/13880209.2017.1310905
Saad A, Siddiqui MMH, Aleem S et al (2002) Effect of Namak Chirchita (Achyranthes aspera Linn.) in Zeeq-un-Nafs Sho’bi (bronchial asthma). Hamdard Med 45:37–40
Saxena RC (2003) Antihistaminic activity of the Saponin isolated from Achyranthes aspera Linn. Presented paper published in the proceeding of 3rd World Congress on Medicinal & Aromatic Plant (WOCMAP), 3–7 Feb., Chiang Mai University, Thailand. pp 137
Soundararajan P, Mahesh R, Ramesh T et al (2006) Effect of Aerva lanata on calcium oxalate urolithiasis in rats. Indian J Exp Biol 44:981–986
Sabahi M, Mansouri SH, Ramezanian M (1987) Antimicrobial activity of amaranthaceous plants. Int J Crude Drugs Res 25:72
Nevin KG, Vijayammal PL (2003) Effect of Aerva lanata on solid tumor induced by DLA cells in mice. Fitoterapia 74:578. https://doi.org/10.1016/S0367-326X(03)00148-5
Vetrichelvan T, Jegadeesan M (2002) Anti-diabetic activity of alcoholic extract of Aerva lanata (L) Juss.Ex.Schultes in rats. J Ethnopharmacol 80:103. https://doi.org/10.1016/s0378-8741(01)00412-3
Shirwaikar A, Issac D, Malini S (2004) Effect of Aerva lanata on Cisplatin and gentamicin models of acute renal failure. J Ethnopharmacol 90:81–86. https://doi.org/10.1016/j.jep.2003.09.033
Nevin KG, Vijayammal PL (2006) Pharmacological and immunomodulatory effects of Aerva lanata in Daltons lymphoma ascites bearing mice. Pharm Biol 43:640–646. https://doi.org/10.1080/13880200500303858
Agharkar SP (ed) (1991) Medicinal plants of Bombay presidency. Scientific Publishers, Jodhpur, pp 41–213
Savithramma N, Sulochana C, Rao KN (2007) Ethnobotanical survey of plants used to treat asthma in Andhra Pradesh, India. J Ethnopharmacol 113:54–61. https://doi.org/10.1016/j.jep.2007.04.004
Bhalke RD, Gosavi SA (2009) Anti-stress and antiallergic effect of Argemone mexicana stems in asthma. Arch Pharm Sci Res 1:127–129
Ezike AC, Akah PA, Okoli CO (2008) Bronchospasmolytic activity of the extract and fractions of Asystasia gangetica leaves. Int J Appl Res Nat Prod 1:8–12
Khare C (2007) Indian medicinal plants: an illustrated dictionary. Springer-Verlag, Berlin, pp 699–700
Seo BS, Park YK (2015) Effect of Cassiae semen extract on ovalbumin-induced allergic asthma in mice. Korea J Herbol 30(1):25–32
Aher AN, Pal SC, Patil UK et al (2009) Evaluation of anthistaminic activity of Casuarina equisetifolia frost (Casuarinaceae). Pharmacologyonline 1:1144–1149
Ogunlesi M, Okiei W, Ofor E, Osibote AE (2009) Analysis of the essential oil from the dried leaves of Euphorbia hirta Linn (Euphorbiaceae), a potential medication for asthma. Afr J Biotechnol 8:7042–7050. https://doi.org/10.5897/AJB09.1324
Bhujbal SS, Kumar D, Deoda RS et al (2009) Antiasthmatic activity of roots of Hemidesmus indicus R. Br Pharmacologyonline 1:209–216
Gobindgarh M (2016) Role of Pushkarmool in the asthma management: a conceptual study. J Trad Nat Med 1:10–12
Mali RG, Mahajan SG, Mehta AA (2007) Lepidium sativum (garden cress): a review of contemporary literature and medicinal properties. Orient Pharm Exp Med 7:331–335. https://doi.org/10.3742/opem.2007.7.4.331
Dorsch W, Stuppner H, Wagner H et al (1991) Antiasthmatic effects of Picrorhiza kurroa: androsin prevents allergen-and PAF-induced bronchial obstruction in Guinea pigs. Int Arch Allergy Immunol 95:128–133. https://doi.org/10.1159/000235416
Gani HMO, Hoq MO, Tamanna T (2019) Ethnomedicinal, phytochemical and pharmacological properties of Piper longum (Linn). Asian J Med Biol Res 5:1–7. https://doi.org/10.3329/ajmbr.v5i1.41038
Li J, Zhang F, Li J (2015) The immunoregulatory effects of traditional chinese medicine on treatment of asthma or asthmatic inflammation. Am J Chin Med 43:1059–1081. https://doi.org/10.1142/S0192415X15500615
Jang MH, Piao XL, Kim JM et al (2008) Inhibition of cholinesterase and amyloid-beta aggregation by resveratrol oligomers from Vitis amurensis. Phytother Res 22:544–549. https://doi.org/10.1002/ptr.2406
Patil SP, Ji WJ, Singha A et al (2010) In vitro immunomodulatory effect of ASHMI (anti-asthma herbal medicine intervention) on PBMCs from asthmatics. J Allergy Clin Immunol 125:AB198. https://doi.org/10.1016/j.jaci.2009.12.772
Isohama Y, Moriuchi H, Kai H, Miyata T (2002) Glucocorticoid-like and glucocorticoid-unlike regulation of gene expression by Bakumondo-to (Mai-Men-Dong-Tang) in airway epithelial cells. Kampo Med 53:1–9
Tamaoki J, Chiyotani A, Takeyama K et al (1993) Potentiation of beta-adrenergic function by saiboku-to and bakumondo-to in canine bronchial smooth muscle. Jpn J Pharmacol 62:155–159. https://doi.org/10.1254/jjp.62.155
Kajaria D, Tripathi JS, Tiwari SK et al (2012) Anti-histaminic, mast cell stabilizing and bronchodilator effect of hydroalcoholic extract of polyherbal compound–Bharangyadi. Anc Sci Life 31:95. https://doi.org/10.4103/0257-7941.103182
Zhang Y, Guo H, Cheng BCY et al (2018) Dingchuan tang essential oil inhibits the production of inflammatory mediators via suppressing the IRAK/NF-κB, IRAK/AP-1, and TBK1/IRF3 pathways in lipopolysaccharide-stimulated RAW264.7 cells. Drug Des Devel Ther 12:2731–2748. https://doi.org/10.2147/DDDT.S160645
Rao DS, Jayaraaj IA, Jayaraaj R (2005) Antiasthmatic role of “Pentapala-04” a herbal formulation against ova albumin and aluminium hydroxideinduced lung damage in rats. Anc Sci Life 24:134
Srinivasarao D, Jayraaj IA (2004) Evaluation of activity of a herbal formulation “Pentapala 04” on the lung lipids against ova albumin and aluminium hydroxide induced lung damage in rats. Anc Sci Life 26:68–72
Yun L, Xin-Sheng F, Jing-Hua Y et al (2014) CD4+CD25+FOXP3+ T cells, Foxp3 gene and protein expression contribute to antiasthmatic effects of San’ao decoction in mice model of asthma. Phytomedicine 21:656–662. https://doi.org/10.1016/j.phymed.2013.11.009
Wang P, Liu H, Fan X et al (2019) Effect of San’ao decoction on aggravated asthma mice model induced by PM2.5 and TRPA1/TRPV1 expressions. J Ethnopharmacol 236:82–90. https://doi.org/10.1016/j.jep.2019.02.043
Chang TT, Huang CC, Hsu CH (2006) Clinical evaluation of the Chinese herbal medicine formula STA-1 in the treatment of allergic asthma. Phytother Res 20:342–347. https://doi.org/10.1002/ptr.1843
Chang RS, Wang SD, Wang YC et al (2013) Xiao-Qing-long-Tang shows preventive effect of asthma in an allergic asthma mouse model through neurotrophin regulation. BMC Complement Altern Med 13:1–13. https://doi.org/10.1186/1472-6882-13-220
Chang X, Lu Z, Qingxiang Z et al (2020) Winyanghuayin decoction and Xiaoqinglong decoction treatment airway inflammation of Cold Asthma Through PI3K-mTOR signal pathway. https://doi.org/10.21203/rs.3.rs-38579/v1
Kelly-Pieper K, Patil SP, Busse P et al (2009) Safety and tolerability of an antiasthma herbal formula (ASHMI) in adult subjects with asthma: a randomized, double-blinded, placebo-controlled, dose-escalation phase I study. J Altern Complement Med 15:735–743. https://doi.org/10.1089/acm.2008.0543
Busse PJ, Schofield B, Birmingham N et al (2010) The traditional Chinese herbal formula ASHMI inhibits allergic lung inflammation in antigen-sensitized and antigen-challenged aged mice. Ann Allergy Asthma Immunol 104:236–246. https://doi.org/10.1016/j.anai.2009.12.006
Srivastava KD, Dunkin D, Liu C et al (2014) Effect of antiasthma simplified herbal medicine INTERVEntion on neutrophil predominant airway inflammation in a ragweed sensitized murine asthma model. Ann Allergy Asthma Immunol 112:339–347. https://doi.org/10.1016/j.anai.2014.01.021
Chan CK, Kuo ML, Shen JJ et al (2006) Ding Chuan Tang, a Chinese herb decoction, could improve airway hyper-responsiveness in stabilized asthmatic children: a randomized, double-blind clinical trial. Pediatr Allergy Immunol 17:316–322. https://doi.org/10.1111/j.1399-3038.2006.00406.x
Li Y, Wang MY, Fan XS et al (2010) Effect of san-ao decoction, a traditional Chinese prescription, on IL-4 treated normal human bronchial epithelium. J Ethnopharmacol 131:104–109. https://doi.org/10.1016/j.jep.2010.06.006
Kajaria D, Tripathi J, Tiwari S (2014) Anti-asthmatic effect of Shirishadi compound through nasal spray actuation. Ayu 35:261. https://doi.org/10.4103/0974-8520.153738
Kung YY, Chen YC, Hwang SJ, et al (2016) The prescriptions frequencies and patterns of Chinese herbal medicine for allergic rhinitis in Taiwan. Allergy 61:1316–1318
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Das, T., Nandy, S., Dey, A. (2021). Asthma-Induced Inflammatory Responses and Reversal by Botanicals. In: Dua, K., Nammi, S., Chang, D., Chellappan, D.K., Gupta, G., Collet, T. (eds) Medicinal Plants for Lung Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-33-6850-7_4
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