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Lipid Metabolism in Cancer Cells

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Lipid Metabolism in Tumor Immunity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1316))

Abstract

Metabolic reprogramming is one of the most critical hallmarks in cancer cells. In the past decades, mounting evidence has demonstrated that, besides the Warburg Effect, lipid metabolism dysregulation is also one of the essential characteristics of cancer cell metabolism. Lipids are water-insoluble molecules with diverse categories of phosphoglycerides, triacylglycerides, sphingolipids, sterols, etc. As the major utilization for energy storage, fatty acids are the primary building blocks for synthesizing triacylglycerides. And phosphoglycerides, sphingolipids, and sterols are the main components constructing biological membranes. More importantly, lipids play essential roles in signal transduction by functioning as second messengers or hormones. Much evidence has shown specific alterations of lipid metabolism in cancer cells. Consequently, the structural configuration of biological membranes, the energy homeostasis under nutrient stress, and the abundance of lipids in the intracellular signal transduction are affected by these alterations. Furthermore, lipid droplets accumulate in cancer cells and function adaptively to different types of harmful stress. This chapter reviews the regulation, functions, and therapeutic benefits of targeting lipid metabolism in cancer cells. Overall, this chapter highlights the significance of exploring more potential therapeutic strategies for malignant diseases by unscrambling lipid metabolism regulation in cancer cells.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (81773262 and 81902897) and the Independent Program of the State Key Laboratory of Cancer Biology, China (CBSKL2019ZZ21).

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Authors and Affiliations

  1. Department of Medical Genetics and Developmental Biology, The Fourth Military Medical University, Xi’an, People’s Republic of China

    Minhua Zheng

  2. Department of Immunology, The Fourth Military Medical University, Xi’an, People’s Republic of China

    Wei Wang & Rui Zhang

  3. Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi’an, People’s Republic of China

    Jun Liu, Xiao Zhang & Rui Zhang

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  1. Minhua Zheng
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  1. Department of Medical Oncology, Chongqing University Cancer Hospital, Chongqing, China

    Yongsheng Li

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Zheng, M., Wang, W., Liu, J., Zhang, X., Zhang, R. (2021). Lipid Metabolism in Cancer Cells. In: Li, Y. (eds) Lipid Metabolism in Tumor Immunity. Advances in Experimental Medicine and Biology, vol 1316. Springer, Singapore. https://doi.org/10.1007/978-981-33-6785-2_4

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