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Distant Metastases in Patients with Primary Uveal Melanoma

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Advances in Intelligent Information Hiding and Multimedia Signal Processing

Part of the book series: Smart Innovation, Systems and Technologies ((SIST,volume 212))

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Abstract

The distant metastases in uveal melanoma are not thoroughly investigated. Records of 3369 patients with primary uveal melanoma from 2010 to 2016 in the Surveillance, Epidemiology, and End Result (SEER) database were analyzed for the incidence of distant metastases and overall survival of patients with metastases were calculated. Risk factors for metastasis occurrence and prognostic factors for survival were investigated by logistic regression analysis and Cox hazard regression. Sixty-three patients (1.87%) presented distant metastases, including 49, 17, 16, and 6 patients with metastasis to liver, brain, lung, and bone, respectively. Higher T stage (T3 OR = 3.34, 95% CI: 1.16–9.57; T4 OR = 12.44, 95% CI: 4.63–33.46) and N1 stage (OR = 105.57, 95% CI: 13.40–832.13) were risk factors for distant metastases. The median overall survival for patients with distant metastases was 9.0 (95% CI: 6.37–11.63) months with a 2-year survival rate of 25.2%. Age >60 years (HR = 2.91, 95% CI: 1.49–5.68) and tumor at ciliary body (HR = 2.33, 95% CI: 1.11–4.87) were associated with worse survival. The survival was significantly dismal in patients with primary uveal melanoma and distant metastases, especially those with hepatic metastasis. T3-4 stage was risk factor for the development of distant metastases while patients with age >60 years or tumor at the ciliary body were significantly associated with worse survival.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (61802209).

Author information

Authors and Affiliations

  1. School of Medicine, Nankai University, Tianjin, China

    Xiao Sun, Yongjun Piao, Rong Xiang & Yan Wang

  2. Clinical College of Ophthalmology, Tianjin Medical University, No 4. Gansu Road, He-ping District, Tianjin, 300020, China

    Yan Wang

  3. Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin Eye Hospital & Eye Institute, Tianjin, China

    Yan Wang

Authors
  1. Xiao Sun
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  2. Yongjun Piao
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  3. Rong Xiang
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  4. Yan Wang
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Corresponding author

Correspondence to Yan Wang .

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Editors and Affiliations

  1. College of Computer Science and Engineering, Shandong University of Science and Technology, Qingdao, Shandong, China

    Jeng-Shyang Pan

  2. Northeast Electric Power University, Jilin, Jilin, China

    Jianpo Li

  3. College of Electrical & Computer Engineering, Chungbuk National University, Cheongju, Korea (Republic of)

    Keun Ho Ryu

  4. Fujian University of Technology, Fuzhou, China

    Zhenyu Meng

  5. Faculty of Sciences, University of Novi Sad, Novi Sad, Serbia

    Aleksandra Klasnja-Milicevic

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Sun, X., Piao, Y., Xiang, R., Wang, Y. (2021). Distant Metastases in Patients with Primary Uveal Melanoma. In: Pan, JS., Li, J., Ryu, K.H., Meng, Z., Klasnja-Milicevic, A. (eds) Advances in Intelligent Information Hiding and Multimedia Signal Processing. Smart Innovation, Systems and Technologies, vol 212. Springer, Singapore. https://doi.org/10.1007/978-981-33-6757-9_29

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