Abstract
Nanoceramics are ultrafine particles with particle size less than 100 nm and have greater advantages over macroscale ceramics which are brittle and rigid. They are inorganic, metallic and non-metallic compounds that have high heat resistance. Their small particle size offers them unique properties which have led to their widespread use in various fields. Their improved properties include bioactivity, dielectricity, ferromagnetism, piezoelectricity, magnetoresistance and superconductivity. Hardness and strength of ceramics are greatly improved by reducing their particle size to be in the nanoscale. Nanoceramics can be conveniently prepared by various physical and chemical methods in various sizes and shapes such as nanoparticles, nanorods, nanotubes, nanoribbons, nanosheets and nanofluids which determines their properties. Characterization of nanoceramics can be carried out by surface characterization methods such as X-ray diffraction analysis, Infrared spectroscopy, Scanning electron Microscopy, Transmission Electron Microscopy, Atomic Force Microscopy, etc. Nanoceramic particles can be used for bone repair, drug delivery, energy supply and storage, communication, transportation systems and construction. The current article discusses in detail the nanoceramics, their preparation methods, various characterization techniques, their unique properties and their application in the biomedical field arising due to their excellent properties.
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References
Khalil KA (2012) Advanced sintering of nano-ceramic materials. In: Ceramic materials-progress in modern ceramics, InTechOpen, London
Smith KT (2019) What are nanoceramics and their applications? Accessed March 3. https://azonano.com/article.aspx?ArticleID=5143
Thomas SC, Harshita, Mishra PK, Talegaonkar S (2015) Ceramic nanoparticles: fabrication methods and applications in drug delivery. Curr Pharm Des 21:6165–88
Virk HS, Poonam S (2010) Chemical route to nanotechnology. Int J Adv Eng Technol 1:114–129
Kiani A, Rahmani M, Manickam S, Tan B (2014) Nanoceramics: synthesis, characterization, and applications. J Nanomat 2014:1–2
Sharma RK, Sharma P, Maitra A (2003) Size-dependent catalytic behavior of platinum nanoparticles on the hexacyanoferrate(III)/thiosulfate redox reaction. J Colloid Interface Sci 265:134–140
Miyake H, Yuba Y, Gamo K, Namba S (1988) Defects induced by focused ion beam implantation in GaAs. J Vac Sci Technol B: Microelectron Process Phenom 6:1001
Ting HT, Hossein KA, Chua HB (2009) Review of micromachining of ceramics by etching. T Nonferr Metal Soc China 19:1–16
Wakamatsu MH, Salomão R (2010) Ceramic nanoparticles: what else do we have to know? InterCeram: Inter Ceram Rev 59:28–33
Hiemenz PC, Rajagopalan R (1997) Principles of colloidal and surface chemistry, revised and expanded, 3rd edn. CRC Press, New York
Wakamatsu MH, Salomão R (2011) (Unintentional) synthesis of ceramic nanoparticles. InterCeram: Inter Ceram Rev 60:364–369
Rao CNR, Müller A, Cheetham AK (2004) The chemistry of nanomaterials: synthesis, properties and applications, vol 1. Wiley-VCH Verlag, Weinheim
Vashist SK (2013) Magnetic nanoparticles-based biomedical and bioanalytical applications. J Nanomed Nanotechnol 4:1000–1130
Xie L, Abliz D, Li D (2014) Thin film coating for polymeric micro parts, Vol. 7 comprehensive materials processing, reference module in materials science and materials engineering, Elsevier Publications, London
Rane AV, Kanny K, Abitha VK, Thomas S (2018) Methods for synthesis of nanoparticles and fabrication of nanocomposites. In: Synthesis of inorganic nanomaterials, micro and nano technologies, Woodhead Publishing, Massachusetts.
Goharian A (2019) Porous osseoconductive layering for enhancement of osseointegration. In: Osseointegration of orthopaedic implants, Academic Press, Cambridge, England.
Ballo AM, Bjoorn D, Astrand M, Palmquist A, Lausmaa J, Thomsen P (2013) Bone response to physical-vapour-deposited titanium dioxide coatings on titanium implants. Clin Oral Implants Res 24(9):1009–1017
Bazaka K, Jacob MV, Crawford RJ, Ivanova EP (2012) Efficient surface modification of biomaterial to prevent biofilm formation and the attachment of microorganism’s. Appl Microbiol Biotechnol 95:299–311
Cao G (2014) Nanostructures & Nanomaterials: synthesis, properties & applications. Imperial College Press, London
Kumar DS, Kumar BJ, Mahesh HM (2018) Chapter 3—Quantum Nanostructures’. In: Synthesis of inorganic nanomaterials, micro and nano technologies, Woodhead Publishing, Cambridge, England.
Ataol S, Tezcaner Duygulu O, Keskin D, Machin NE (2015) Synthesis and characterization of nanosized calcium phosphates by flame spray pyrolysis and their effect on osteogenic differentiation of stem cells. J Nanopart Res 17:1–14
An GH, Wang HJ, Kim BH et al (2014) Fabrication and characterization of a hydroxyapatite nanopowder by ultrasonic spray pyrolysis with salt-assisted decomposition. Mater Sci Eng, A 449–451:821–824
Kulkarni M, Mazare A, Schmuki P et al (2014) Biomaterial surface modification of titanium and titanium alloys for medical applications. In: Nanomedicine, UK Central Press, Cambridge
Giavaresi G, Ambrosio L, Battiston GA et al (2004) Histomorphometric, ultrastructural and microhardness evaluation of the osseointegration of a nanostructured titanium oxide coating by metal-organic chemical vapour deposition: an in vivo study. Biomater 25(25):5583–5591
Szili EJ, Kumar S, Smart RSC, Voelcker NH (2009) Generation of a stable surface concentration of amino groups on silica coated onto titanium substrates by the plasma enhanced chemical vapour deposition method. Appl Surf Sci 255(15):6846–6850
Gennari FC, Gamboa JJA (2018) A Systematic approach to the synthesis, thermal stability and hydrogen storage properties of rare-earth borohydrides. In: Emerging Materials from Energy Conversion and Storage, Elsevier Publications, London.
Tsuzuki T, McCormick PG (2004) Mechanochemical synthesis of nanoparticles. J Mater Sci 39:5143–5146
Benabdeslam HEB, Ginebra MP, Vert M (2008) Wet or dry mechanochemical synthesis of calcium phosphates? Influence of the water content on DCPD-CaO reaction kinetics. Acta Biomater 4(2):378–386
Singh Z (2018) Nanoceramics in bone tissue engineering: the future lies ahead. Trends J Sci Res 3:120–123
Bulina NV, Chaikina MV, Prosanov IY (2018) Lanthanum-silicate-substituted apatite synthesized by fast mechanochemical method: characterization of powders and biocoatings produced by micro-arc oxidation. Mater Sci Eng, C 92:435–446
Balaz M, Daneu N, Balazova L (2017) Bio-mechanochemical synthesis of silver nanoparticles with antibacterial activity. Adv Powder Technol 28(12):3307–3312
Fahami A, Kahrizsangi RE, Tabrizi BN (2011) Mechanochemical synthesis of hydroxyapatite/titanium nanocomposite. Solid State Sci 13(1):135–141
BenAbdeslam HEB, Mochales C, Ginebra MP et al (2003) Dry mechanochemical synthesis of hydroxyapatites from dicalcium phosphate dihydrate and calcium oxide: a kinetic study. J Biomed Mater Res A 67A(3):927–937
Huang A, Dai H, Wu X, Zhao Z et al (2019) Synthesis and characterization of mesoporous hydroxyapatite powder by microemulsion technique. J Mater Res Technol 8(3):3158–3166
Xu H, Cheng L, Wang C et al (2011) Polymer encapsulated upconversion nanoparticle/iron oxide nanocomposites for multimodal imaging and magnetic targeted drug delivery. Biomater 32(35):9364–9373
Pottathara YB, Grohens Y, Kokol V et al (2019) Synthesis and processing of emerging two-dimensional nanomaterials. In: Nanomaterials synthesis, design, fabrication and applications, micro and nano technologies, Elsevier Publications, London
Lugo VR, Karthik TVK, Anaya DM, Rosas ER (2018) Wet chemical synthesis of nanocrystalline hydroxyapatite flakes: effect of pH and sintering temperature on structural and morphological properties. R Soc Open Sci 5(8):180962
Stipniece L, Ancane KS, Borodajenko N (2014) Characterization of Mg-substituted hydroxyapatite synthesized by wet chemical method. Ceram Inter 40(2):3261–3267
Pauline SA, Mudali UK, Rajendran N (2013) Fabrication of nanoporous Sr-incorporated TiO2 coating on 316L SS: evaluation of bioactivity and corrosion protection. Mater Chem Phy 142:27–36
Pauline SA, Rajendran N (2014) Effect of Sr on the bioactivity and corrosion resistance of nanoporous niobium oxide coating for orthopaedic applications. Mater Sci Eng, C 36:194–205
Maho A, Detriche S, Delhalle J et al (2013) Sol-gel synthesis of tantalum oxide and phosphonic acid-modified carbon nanotubes composite coatings on titanium surfaces. Mater Sci Eng, C 33(5):2686–2697
Georgescu D, Brezoiu AM, Mitran RA et al (2017) Mesostructured silica-titania composites for improved oxytetracycline delivery systems. C R Chim 20:1017–1025
Foss CA (2003) Optical properties of nanoparticle pair structures. In: Encyclopedia of materials: science and technology, Elsevier Publications, London
Cao G, Liu D (2008) Template-based synthesis of nanorod, nanowire, and nanotube arrays. In: Springer handbook of nanotechnology, Springer, New York. 136(1–2):45–64
Regi MV (2010) Evolution of bioceramics within the field of biomaterials. C R Chim 13(1–2):174–185
Fan J, Lei J, Yu C (2007) Hard-templating synthesis of a novel rod-like nanoporous calcium phosphate bioceramics and their capacity as antibiotic carriers. Mater Chem Phy 103(2–3):489–493
Wang M, Guo L, Sun H (2019) Manufacture of biomaterials. In: Encyclopedia of biomedical engineering, Elsevier Publications, London
Shin K, Acri T, Geary S et al (2017) Biomimetic mineralization of biomaterials using simulated body fluids for bone tissue engineering and regenerative medicine. Tissue Eng Part A 23(19–20):1169–1180
Stefanic M, Krnel K, Pribosic I et al (2012) Rapid biomimetic deposition of octacalcium phosphate coatings on zirconia ceramics (Y-TZP) for dental implant applications. Appl Surf Sci 258(10):4649–4656
Bigi A, Boanini E, Bracci B et al (2005) Nanocrystalline hydroxyapatite coatings on titanium: a new fast biomimetic method. Biomater 26:4085–4089
Fathyunes L, Khalil-Allafi J, Moosavifar M (2019) Development of graphene oxide/calcium phosphate coating by pulse electrodeposition on anodized titanium: Biocorrosion and mechanical behavior. J Mech Behav Biomed Mater 90:575–586
Drevet R, Zhuova Y, Dubinskiy S et al (2019) Electrodeposition of cobalt-substituted calcium phosphate coatings on Ti-22Nb-6Zr alloy for bone implant applications. J Alloys Compd 793:576–582
Poorraeisi M, Afshar A (2018) The study of electrodeposition of hydroxyapatite-ZrO2-TiO2 nanocomposite coatings on 316 stainless steel. Surf Coat Technol 339:199–207
Pontoni D, Narayanan T, Rennie AR (2002) Tr-saxs study of nucleation and growth of sillica colloids. Langmuir 18:56–59
Ebnesajid S (2014) Chapter 4—Surface and material characterization techniques. In: Surface treatment of materials for adhesive bonding. William Andrew Applied Science Publishers, New York
Ismail AF, Khulbe KC, Matsuura T (2019) Chapter 3—RO membrane characterization. In: Reverse osmosis. Elsevier Publications, London
Bergstrom J (2015) 2—Experimental characterization techniques, mechanics of solid polymers. In: Theory and computational modeling. William Andrew Applied Science Publishers, New York
Ratner BD (2013) Chapter I.1.5—Surface Properties and Surface Characterization of Biomaterials. In: Biomaterials science (Third Edition), an introduction to materials in medicine. Academic Press, Cambridge, England.
Ven ALVD, Mack A, Dunner Jr K et al (2012) Chapter one—preparation, characterization, and cellular associations of silicon logic-embedded vectors. In: Methods in enzymology, vol. 508. Elsevier Publications, London
Bajpai OP, Panja S, Chattopadhyay S et al (2015) Process-structure-property relationships in nanocomposites based on piezoelectric-polymer matrix and magnetic nanoparticles. In: Manufacturing of nanocomposites with engineering plastic. Elsevier Publications, London
Cuenat A, Leah R (2014) Chapter 7—Scanning probe and particle beam microscopy. In: Fundamental principles of engineering nanometrology (2nd edn), micro and nano technologies. William Andrew Applied Science Publishers, New York
Ramakrishna BL, Ong EW (2001) Surface evaluation by atomic force microscopy. In: Encyclopedia of materials: science and technology (2nd edn), Elsevier Publications, London
Shi D, Guo Z, Bedford N (2015) 2-Characterization and Analysis of Nanomaterials. In: Nanomaterials and Devices, Micro and Nano Technologies. William Andrew Applied Science Publishers, New York
Causserand C, Aimar P (2010) 1.15—Characterization of filtration membranes. In: Comprehensive membrane science and engineering, vol. 1. Elsevier Publications, London
McCluskey MD (2017) High-pressure IR. In: Encyclopedia of spectroscopy and spectrometry (3rd edn), reference module in chemistry, molecular sciences and chemical engineering. Elsevier Publications, London
Ohara S, Adschiri T, Ida T, Yashima M et al (2012) Chapter 5 - Characterization methods for nanostructure of materials. In: Nanoparticle technology handbook (2nd edn). Elsevier Publications, London
Mather RR (2009) 13—Surface modification of textiles by plasma treatments. In: Surface modification of textiles. Woodhead Publishing Series in Textiles, Cambridge
Arcos D, Regi MV (2013) Bioceramics for drug delivery. Acta Mater 61:890–911
Smith AJ, Dieppe P, Vernon K et al (2012) Failure rates of stemmed metal-on-metal hip replacements: analysis of data from the national joint registry of England and Wales. The Lancet 379:1199–1204
Wang CJ, Huang TW, Wang JW et al (2002) The often poor clinical outcome of infected total knee arthroplasty. J Arthroplasty 17:608–614
Simchi A, Eng D, Tamjid E (2011) Recent progress in inorganic and composite coatings with bactericidal capability for orthopaedic applications. Nanomedicine 7:22–39
Duan K, Wang R (2006) Surface modifications of bone implants through wet chemistry. J Mater Chem 16:2309–2321
In HSF, Hench LL, Editors WJ (1993) An introduction to bioceramics. World Scientific, Singapore
Huang HL, Chang YY, Weng JC (2013) Anti-bacterial performance of Zirconia coatings on Titanium implants. Thin Solid Films 528:51–156
Khanna R, Kokubo T, Matsushita T et al (2016) Fabrication of dense α-alumina layer on Ti-6Al-4 V alloy hybrid for bearing surfaces of artificial hip joint. Mater Sci Eng, C 69:1229–1239
Hench LL (1991) Bioceramics: from concept to clinic. J Am Ceram Soc 74:1487–1510
Lakstein D, Kopelovitch W, Barkay Z et al (2009) Enhanced osseointegration of grit-blasted, NaOH-treated and electrochemically hydroxyapatite-coated Ti-6Al-4 V implants in rabbits. Acta Biomater 5:2258–2269
Esteban SL, Saiz E, Fujino S et al (2003) Bioactive glass coatings for orthopedic metallic implants. J Eur Ceram Soc 23(15):2921–2930
Tarpani L, Morena F, Gambucci M (2016) The influence of modified silica nanomaterials on adult stem cell culture. Nanomaterials 6:104–114
Hench LL, Xynos ID, Polak JM (2004) Bioactive glasses for in situ tissue regeneration. J Biomater Sci. Polymer Edition 15:543–562
Habraken WJEM, Walke JGC, Jansen JA (2007) Ceramic composites as matrices and scaffolds for drug delivery in tissue engineering. Adv Drug Deliv Rev 59:234–248
Fu L, Xiong Y, Carlsson G et al (2018) Biodegradable Si3N4 bioceramic sintered with Sr, Mg and Si for spinal fusion: surface characterization and biological evaluation. Appl Mater Today 12:260–275
Nabiyouni M, Bruckner T, Zhou H et al (2018) Magnesium-based bioceramics in orthopedic applications. Acta Biomater 66:23–43
Liu H, Webster TJ (2007) Nanomedicine for implants: a review of studies and necessary experimental tools. Biomater 28:354–369
Ainslie KM, Tao SL, Popat KC et al (2008) In vitro inflammatory response of nanostructured titania, silicon oxide, and polycaprolactone. J Biomed Mater Res, Part A 91:647–655
Luginbuehl V, Meinel L, Merkle HP et al (2004) Localized delivery of growth factors for bone repair. Eur J Pharm 58:197–208
Chao CS, Liu KH, Tung WL et al (2012) Bioactive TiO2 ultrathin film with worm-like mesoporosity for controlled drug delivery. Micropor Mesopor Mat 152:58–63
Couto DS, Alves NM, Mano JF (2008) Nanostructured multilayer coatings combining chitosan with bioactive glass nanoparticles. J Nanosci Nanotechnol 8:1–8
Mahlooji E, Atapour M, Labbaf S (2019) Electrophoretic deposition of Bioactive glass—chitosan nanocomposite coatings on Ti-6Al-4 V for orthopaedic applications. Carbohydr Polym 226:115299
Kumar AM, Adesina AY, Hussein MA (2019) PEDOT/FHA nanocomposite coatings on newly developed Ti-Nb-Zr implants: biocompatibility and surface protection against corrosion and bacterial infections. Mater Sci Eng, C 98:482–495
Goncalves SEP, Bresciani E (2017) Reconstructions using alloys and ceramics. In: Material-tissue interfacial phenomena. Elsevier Publications, London.
Wu H, Xie L, He M et al (2019) A wear-resistant TiO2 nanoceramic coating on titanium implants for visible-light photocatalytic removal of organic residues. Acta Biomater 97:597–607
Pekkan G, Pekkan K, Park J et al (2016) A study on microstructural characterization of the interface between apatite-wollastonite based glass ceramic and feldspathic dental porcelain. Ceram Inter 42(16):19245–19249
Donovan TE (2008) Factors essential for successful all-ceramic restorations. J Am Dent Assoc 139:14S–18S
Koutayas SO, Vagkopoulou T, Pelekanos S et al (2009) Zirconia in dentistry: part 2. Evidence-based clinical breakthrough. Eur J Esthet Dent 4(4):348–380
Regi MV, Balas F, Arcos D (2007) Mesoporous materials for drug delivery. Angew Chem Int Ed 46:7548–7558
Regi MV, Balas F, Colilla M et al (2008) Bone-regenrative bioceramic implants with drug and protein controlled delivery capability. Solid State Sci 1:163–191
Datt A, Burns EA, Dhuna NA et al (2013) Loading and release of 5-fluorouracil from HY zeolites with varying SiO2/Al2O3 ratios. Micropor Mesopor Mater 167:182–187
Ozdemir V, Glatt BWJSJ, Tsuang MT et al (2006) Shifting emphasis from pharmacogenomics to theragnostics. Nat Biotechnol 24:942–946
Yi H, Rehman FU, Zhao C (2016) Recent advances in nano scaffolds for bone repair. Bone Res 4:1–11
Ansari AA, Hasan TN, Syed et al (2013) In-vitro cyto-toxicity, geno-toxicity, and bio-imaging evaluation of one-pot synthesized luminescent functionalized mesoporous SiO2@Eu(OH)3 core-shell microspheres. Nanomedicine 9:1328–1335
Yang W, Tian H, Liao J (2020) Flexible and strong Fe3O4/cellulose composite film as magnetic and UV sensor. Appl Surf Sci 507:145092
Shi Z, Huang X, Cai Y et al (2009) Size effect of hydroxyapatite nanoparticles on proliferation and apoptosis of osteoblast-like cells. Acta Biomater 5:338–345
Khan Y, Yaszemski MJ, Mikos AG et al (2008) Tissue engineering of bone: material and matrix considerations. J Bone Jt Surg 90:36–42
Dziak R, Mohan K, Almaghrabi B et al (2020) Nanoceramics for bone regeneration in the oral and craniomaxillofacial complex. In: Nanobiomaterials in clinical dentistry. Elsevier Publications, London
Deepthi S, Venkatesan J, Kim SK et al (2016) An overview of chitin or chitosan/nano ceramic composite scaffolds for bone tissue engineering. Inter J Biol Macromol 93:1338–1353
Luo Z, Deng Y, Zhang R et al (2015) Peptide-laden mesoporous silica nanoparticles with promoted bioactivity and osteo-differentiation ability for bone tissue engineering. Colloids Surf B 131:73–82
Xia L, Lin K, Jiang X et al (2014) Effect of nano-structured bioceramic surface on osteogenic differentiation of adipose derived stem cells. Biomater 35:8514–8527
Chen P, Liu L, Pan J et al (2019) Biomimetic composite scaffold of hydroxyapatite/gelatin-chitosan core-shell nanofibers for bone tissue engineering. Mater Sci Eng C: Mater Biol Appl 97:325–335
Marsh AC, Mellott NP, Chamorro NP et al (2019) Fabrication and multiscale characterization of 3D silver containing bioactive glass-ceramic scaffolds. Bioact Mater 4:215–223
Kumar SD, Abudhahir KM, Selvamurugan N et al (2018) Formulation and biological actions of nano-bioglass ceramic particles doped with Calcarea phosphorica for bone tissue engineering. Mater Sci Eng C: Mater Biol Appl 83:202–209
Shokrollahi H, Salimi F, Doostmohammadi A (2017) The fabrication and characterization of barium titanate/akermanite nano-bio-ceramic with a suitable piezoelectric coefficient for bone defect recovery. J Mech Behav Biomed Mater 74:365–370
Veloza AM, Hossain KMZ, Scammell BE (2020) Formulating injectable pastes of porous calcium phosphate glass microspheres for bone regeneration applications. J Mech Behav Biomed Mater 102:103489
Ali M, Okamota M, Komichi S (2019) Lithium-containing surface pre-reacted glass fillers enhance hDPSC functions and induce reparative dentin formation in a rat pulp capping model through activation of Wnt/β-catenin signaling. Acta Biomate 96:594–604
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Pauline, S.A. (2021). Nanoceramics: Synthesis, Characterizations and Applications. In: Santra, T.S., Mohan, L. (eds) Nanomaterials and Their Biomedical Applications. Springer Series in Biomaterials Science and Engineering, vol 16. Springer, Singapore. https://doi.org/10.1007/978-981-33-6252-9_5
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