Skip to main content
SpringerLink
Log in

Probiotics for Atopic Dermatitis

  • Chapter
  • First Online:
Probiotic Research in Therapeutics

  • 464 Accesses

Abstract

This chapter provides information regarding the chronic inflammatory skin disorder atopic dermatitis (AD), highlighting the prevalence of the disease, different diagnostic criteria, diagnosis procedures and clinical features of AD. The pathogenesis of AD is multifactorial resulting from complex interplay among immune dysregulation, epidermal barrier disruption, environment, and genetic predisposition, nutritional, psychological and pharmacological factors. Immune dysregulation and epidermal barrier dysfunction are the major pathophysiological defects along with genetic variation in Filaggrin (FLG), the most recurring finding contributing towards AD development. The major risk factors of AD are positive family history, environmental and lifestyle factors, use of broad-spectrum antibiotics in pregnancy and infants especially S. aureus colonisation and superinfections. Sleep disturbance, ADHD, psychiatric disorders, asthma and allergic rhinitis are the co-morbidities associated with chronic skin disease. Though there is no cure for AD, management basically aims at improving symptoms by using therapeutic agents like emollients, calcineurin inhibitors, topical corticosteroids, systemic immunosuppressants and phototherapy depending upon the severity of the symptoms. Gut microbiome impacts AD through immunologic pathway, metabolite pathway and neuroendocrine pathway. Probiotics helps in improving the intestinal barrier by modulating the immune status and intestinal microbiome by performing immunomodulatory effect, metabolic effect and standardisation of microbial composition by protection of the mucosal surface against pathogens. This chapter also explores information regarding various studies linking gut and skin microbiome with AD and also summarises the clinical trials using probiotics as interventions in improving the disease condition.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  • Abrahamsson TR, Jakobsson HE, Andersson AF, Björkstén B, Engstrand L, Jenmalm MC (2012) Low diversity of the gut microbiota in infants with atopic eczema. J Allerg Clin Immunol 129(2):434–440.e432

    Google Scholar 

  • Adams H, Penders J, van den Brandt P, Ree CV, Vink C, Thijs C, Stobberingh E (2006) Molecular fingerprinting of the intestinal microbiota of infants in whom atopic eczema was or was not developing

    Google Scholar 

  • Akay HK, Tokman HB, Hatipoglu N, Hatipoglu H, Siraneci R, Demirci M, Borsa BA, Yuksel P, Karakullukcu A, Kangaba AA (2014) The relationship between bifidobacteria and allergic asthma and/or allergic dermatitis: a prospective study of 0–3 years-old children in Turkey. Anaerobe 28:98–103

    PubMed  Google Scholar 

  • Alvarez-Olmos MI, Oberhelman RA (2001) Probiotic agents and infectious diseases: a modern perspective on a traditional therapy. Clin Infect Dis 32(11):1567–1576

    CAS  PubMed  Google Scholar 

  • Apfelbacher C, Diepgen T, Schmitt J (2011) Determinants of eczema: population-based cross-sectional study in Germany. Allergy 66(2):206–213

    CAS  PubMed  Google Scholar 

  • Arpaia N, Campbell C, Fan X, Dikiy S, van der Veeken J, Deroos P, Liu H, Cross JR, Pfeffer K, Coffer PJ (2013) Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature 504(7480):451–455

    CAS  PubMed  PubMed Central  Google Scholar 

  • Beattie P, Lewis-Jones M (2006) A comparative study of impairment of quality of life in children with skin disease and children with other chronic childhood diseases. Br J Dermatol 155(1):145–151

    CAS  PubMed  Google Scholar 

  • Bhatia BK, Millsop JW, Debbaneh M, Koo J, Linos E, Liao W (2014) Diet and psoriasis, part II: celiac disease and role of a gluten-free diet. J Am Acad Dermatol 71(2):350–358

    CAS  PubMed  PubMed Central  Google Scholar 

  • Bonciolini V, Bianchi B, Del Bianco E, Verdelli A, Caproni M (2015) Cutaneous manifestations of non-celiac gluten sensitivity: clinical histological and immunopathological features. Nutrients 7(9):7798–7805

    CAS  PubMed  PubMed Central  Google Scholar 

  • Bora SA, Kennett MJ, Smith PB, Patterson AD, Cantorna MT (2018) The gut microbiota regulates endocrine vitamin D metabolism through fibroblast growth factor 23. Front Immunol 9:408

    PubMed  PubMed Central  Google Scholar 

  • Brenninkmeijer E, Schram M, Leeflang M, Bos J, Spuls PI (2008) Diagnostic criteria for atopic dermatitis: a systematic review. Br J Dermatol 158(4):754–765

    CAS  PubMed  Google Scholar 

  • Buffie CG, Bucci V, Stein RR, McKenney PT, Ling L, Gobourne A, No D, Liu H, Kinnebrew M, Viale A (2015) Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile. Nature 517(7533):205–208

    CAS  PubMed  Google Scholar 

  • Cryan JF, Dinan TG (2012) Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci 13(10):701–712

    CAS  PubMed  Google Scholar 

  • Dawson LF, Donahue EH, Cartman ST, Barton RH, Bundy J, McNerney R, Minton NP, Wren BW (2011) The analysis of Para-cresol production and tolerance in Clostridium difficile 027 and 012 strains. BMC Microbiol 11(1):86

    CAS  PubMed  PubMed Central  Google Scholar 

  • Deckers IAG, McLean S, Linssen S, Mommers M, van Schayck CP, Sheikh A (2012) Investigating international time trends in the incidence and prevalence of atopic eczema 1990-2010: a systematic review of epidemiological studies. PLoS One 7(7)

    Google Scholar 

  • Deckert S, Kopkow C, Schmitt J (2014) Nonallergic comorbidities of atopic eczema: an overview of systematic reviews. Allergy 69(1):37–45

    CAS  PubMed  Google Scholar 

  • Derrien M, Veiga P (2017) Rethinking diet to aid human–microbe symbiosis. Trends Microbiol 25(2):100–112

    CAS  PubMed  Google Scholar 

  • Dominguez-Bello MG, Costello EK, Contreras M, Magris M, Hidalgo G, Fierer N, Knight R (2010) Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci 107(26):11971–11975

    PubMed  PubMed Central  Google Scholar 

  • Drago L, De Grandi R, Altomare G, Pigatto P, Rossi O, Toscano M (2016) Skin microbiota of first cousins affected by psoriasis and atopic dermatitis. Clin Mol Allerg 14(1):2

    Google Scholar 

  • Elias PM, Steinhoff M (2008) “Outside-to-inside”(and now back to “outside”) pathogenic mechanisms in atopic dermatitis. J Investig Dermatol 128(5):1067–1070

    CAS  PubMed  Google Scholar 

  • Enomoto T, Sowa M, Nishimori K, Shimazu S, Yoshida A, Yamada K, Furukawa F, Nakagawa T, Yanagisawa N, Iwabuchi N (2014) Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int 63(4):575–585

    CAS  PubMed  Google Scholar 

  • Feleszko W, Jaworska J, Rha RD, Steinhausen S, Avagyan A, Jaudszus A, Ahrens B, Groneberg D, Wahn U, Hamelmann E (2007) Probiotic-induced suppression of allergic sensitization and airway inflammation is associated with an increase of T regulatory-dependent mechanisms in a murine model of asthma. Clin Exp Allergy 37(4):498–505

    CAS  PubMed  Google Scholar 

  • Flohr C, Mann J (2014) New insights into the epidemiology of childhood atopic dermatitis. Allergy 69(1):3–16

    CAS  PubMed  Google Scholar 

  • Flohr C, Yeo L (2011) Atopic dermatitis and the hygiene hypothesis revisited. In: Pathogenesis and management of atopic dermatitis, vol 41. Karger Publishers, pp 1–34

    Google Scholar 

  • Garmhausen D, Hagemann T, Bieber T, Dimitriou I, Fimmers R, Diepgen T, Novak N (2013) Characterization of different courses of atopic dermatitis in adolescent and adult patients. Allergy 68(4):498–506

    CAS  PubMed  Google Scholar 

  • Gensollen T, Blumberg RS (2017) Correlation between early-life regulation of the immune system by microbiota and allergy development. J Allergy Clin Immunol 139(4):1084–1091

    PubMed  PubMed Central  Google Scholar 

  • Gerbens L, Prinsen C, Chalmers J, Drucker A, von Kobyletzki L, Limpens J, Nankervis H, Svensson Å, Terwee C, Zhang J (2018) Evaluation of the measurement properties of symptom measurement instruments for atopic eczema. A bird’s-eye view on eczema. p 43

    Google Scholar 

  • Gore C, Custovic A, Tannock G, Munro K, Kerry G, Johnson K, Peterson C, Morris J, Chaloner C, Murray C (2012) Treatment and secondary prevention effects of the probiotics L actobacillus paracasei or B ifidobacterium lactis on early infant eczema: randomized controlled trial with follow-up until age 3 years. Clin Exp Allergy 42(1):112–122

    CAS  PubMed  Google Scholar 

  • Gueniche A, Benyacoub J, Philippe D, Bastien P, Kusy N, Breton L, Blum S, Castiel-Higounenc I (2010) Lactobacillus paracasei CNCM I-2116 (ST11) inhibits substance P-induced skin inflammation and accelerates skin barrier function recovery in vitro. Eur J Dermatol 20(6):731–737

    PubMed  Google Scholar 

  • Han Y, Kim B, Ban J, Lee J, Kim BJ, Choi BS, Hwang S, Ahn K, Kim J (2012) A randomized trial of L actobacillus plantarum CJLP 133 for the treatment of atopic dermatitis. Pediatr Allergy Immunol 23(7):667–673

    PubMed  Google Scholar 

  • He J, Zhang F, Han Y (2017) Effect of probiotics on lipid profiles and blood pressure in patients with type 2 diabetes: a meta-analysis of RCTs. Medicine 96(51)

    Google Scholar 

  • Huang YJ, Marsland BJ, Bunyavanich S, O'Mahony L, Leung DY, Muraro A, Fleisher TA (2017) The microbiome in allergic disease: current understanding and future opportunities—2017 PRACTALL document of the American Academy of Allergy, Asthma & Immunology and the European academy of allergy and clinical immunology. J Allergy Clin Immunol 139(4):1099–1110

    PubMed  PubMed Central  Google Scholar 

  • Hulshof L, Van’t Land B, Sprikkelman AB, Garssen J (2017) Role of microbial modulation in management of atopic dermatitis in children. Nutrients 9(8):854

    PubMed Central  Google Scholar 

  • Illi S, von Mutius E, Lau S, Nickel R, Grüber C, Niggemann B, Wahn U, Group MAS (2004) The natural course of atopic dermatitis from birth to age 7 years and the association with asthma. J Allergy Clin Immunol 113(5):925–931

    PubMed  Google Scholar 

  • Jang S-O, Kim H-J, Kim Y-J, Kang M-J, Kwon J-W, Seo J-H, Kim HY, Kim B-J, Yu J, Hong S-J (2012) Asthma prevention by lactobacillus rhamnosus in a mouse model is associated with CD4+ CD25+ Foxp3+ T cells. Allergy Asthma Immunol Res 4(3):150–156

    CAS  PubMed  PubMed Central  Google Scholar 

  • Jin U-H, Lee S-O, Sridharan G, Lee K, Davidson LA, Jayaraman A, Chapkin RS, Alaniz R, Safe S (2014) Microbiome-derived tryptophan metabolites and their aryl hydrocarbon receptor-dependent agonist and antagonist activities. Mol Pharmacol 85(5):777–788

    PubMed  PubMed Central  Google Scholar 

  • Kennedy EA, Connolly J, Hourihane JOB, Fallon PG, McLean WI, Murray D, Jo J-H, Segre JA, Kong HH, Irvine AD (2017) Skin microbiome before development of atopic dermatitis: early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year. J Allergy Clin Immunol 139(1):166–172

    PubMed  PubMed Central  Google Scholar 

  • Kim JE, Kim HS (2019) Microbiome of the skin and gut in atopic dermatitis (AD): understanding the pathophysiology and finding novel management strategies. J Clin Med 8(4):444

    CAS  PubMed Central  Google Scholar 

  • Kim H-J, Kim HY, Lee S-Y, Seo J-H, Lee E, Hong S-J (2013) Clinical efficacy and mechanism of probiotics in allergic diseases. Korean J Pediatr 56(9):369

    CAS  PubMed  PubMed Central  Google Scholar 

  • Kim M-H, Rho M, Choi J-P, Choi H-I, Park H-K, Song W-J, Min T-K, Cho S-H, Cho Y-J, Kim Y-K (2017) A metagenomic analysis provides a culture-independent pathogen detection for atopic dermatitis. Allergy Asthma Immunol Res 9(5):453–461

    CAS  PubMed  PubMed Central  Google Scholar 

  • Kirjavainen P, Arvola T, Salminen S, Isolauri E (2002) Aberrant composition of gut microbiota of allergic infants: a target of bifidobacterial therapy at weaning? Gut 51(1):51–55

    CAS  PubMed  PubMed Central  Google Scholar 

  • Kong HH, Oh J, Deming C, Conlan S, Grice EA, Beatson MA, Nomicos E, Polley EC, Komarow HD, Murray PR (2012) Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis. Genome Res 22(5):850–859

    CAS  PubMed  PubMed Central  Google Scholar 

  • Laborel-Préneron E, Bianchi P, Boralevi F, Lehours P, Fraysse F, Morice-Picard F, Sugai M, Sato'o Y, Badiou C, Lina G (2015) Effects of the Staphylococcus aureus and Staphylococcus epidermidis secretomes isolated from the skin microbiota of atopic children on CD4+ T cell activation. PLoS One 10(10)

    Google Scholar 

  • Laird M, Lo Sicco K (2017) Defining and measuring the scope of atopic dermatitis. Adv Exp Med Biol 1027:93–104. https://doi.org/10.1007/978-3-319-64804-0_9

    Article  PubMed  Google Scholar 

  • Lee H, Park M, Kim S, Park Choo H, Lee A, Lee C (2011) Serotonin induces melanogenesis via serotonin receptor 2A. Br J Dermatol 165(6):1344–1348

    CAS  PubMed  Google Scholar 

  • Lee E, Lee S-Y, Kang M-J, Kim K, Won S, Kim B-J, Choi KY, Kim B-S, Cho H-J, Kim Y (2016) Clostridia in the gut and onset of atopic dermatitis via eosinophilic inflammation. Annal Allergy Asthma Immunol 117(1):91–92.e91

    Google Scholar 

  • Lee M-J, Kang M-J, Lee S-Y, Lee E, Kim K, Won S, Suh DI, Kim KW, Sheen YH, Ahn K (2018a) Perturbations of gut microbiome genes in infants with atopic dermatitis according to feeding type. J Allergy Clin Immunol 141(4):1310–1319

    CAS  PubMed  Google Scholar 

  • Lee S-Y, Lee E, Park YM, Hong S-J (2018b) Microbiome in the gut-skin axis in atopic dermatitis. Allergy Asthma Immunol Res 10(4):354–362

    CAS  PubMed  PubMed Central  Google Scholar 

  • Louis P, Flint HJ (2017) Formation of propionate and butyrate by the human colonic microbiota. Environ Microbiol 19(1):29–41

    CAS  PubMed  Google Scholar 

  • Ly NP, Litonjua A, Gold DR, Celedón JC (2011) Gut microbiota, probiotics, and vitamin D: interrelated exposures influencing allergy, asthma, and obesity? J Allergy Clin Immunol 127(5):1087–1094

    CAS  PubMed  PubMed Central  Google Scholar 

  • Ma Y-Y, Li L, Yu C-H, Shen Z, Chen L-H, Li Y-M (2013) Effects of probiotics on nonalcoholic fatty liver disease: a meta-analysis. World J Gastroenterol WJG 19(40):6911

    PubMed  Google Scholar 

  • Maguire M, Maguire G (2017) The role of microbiota, and probiotics and prebiotics in skin health. Arch Dermatol Res 309(6):411–421

    PubMed  Google Scholar 

  • Maslowski KM, Vieira AT, Ng A, Kranich J, Sierro F, Yu D, Schilter HC, Rolph MS, Mackay F, Artis D (2009) Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 461(7268):1282–1286

    CAS  PubMed  PubMed Central  Google Scholar 

  • Matsumoto M, Ebata T, Hirooka J, Hosoya R, Inoue N, Itami S, Tsuji K, Yaginuma T, Muramatsu K, Nakamura A (2014) Antipruritic effects of the probiotic strain LKM512 in adults with atopic dermatitis. Annal Allergy Asthma Immunol 113(2):209–216.e207

    Google Scholar 

  • Messaoudi M, Lalonde R, Violle N, Javelot H, Desor D, Nejdi A, Bisson J-F, Rougeot C, Pichelin M, Cazaubiel M (2011) Assessment of psychotropic-like properties of a probiotic formulation (lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. Br J Nutr 105(5):755–764

    CAS  PubMed  Google Scholar 

  • Mikó E, Vida A, Kovács T, Ujlaki G, Trencsényi G, Márton J, Sári Z, Kovács P, Boratkó A, Hujber Z (2018) Lithocholic acid, a bacterial metabolite reduces breast cancer cell proliferation and aggressiveness. Biochim Biophys Acta (BBA) Bioenergey 1859(9):958–974

    Google Scholar 

  • Mikó E, Kovács T, Sebő É, Tóth J, Csonka T, Ujlaki G, Sipos A, Szabó J, Méhes G, Bai P (2019) Microbiome—microbial metabolome—cancer cell interactions in breast cancer—familiar, but unexplored. Cell 8(4):293

    Google Scholar 

  • Miniello VL, Brunetti L, Tesse R, Natile M, Armenio L, Francavilla R (2010) Lactobacillus reuteri modulates cytokines production in exhaled breath condensate of children with atopic dermatitis. J Pediatr Gastroenterol Nutr 50(5):573–576

    PubMed  Google Scholar 

  • Miyamoto J, Mizukure T, Park S-B, Kishino S, Kimura I, Hirano K, Bergamo P, Rossi M, Suzuki T, Arita M (2015) A gut microbial metabolite of linoleic acid, 10-hydroxy-cis-12-octadecenoic acid, ameliorates intestinal epithelial barrier impairment partially via GPR40-MEK-ERK pathway. J Biol Chem 290(5):2902–2918

    CAS  PubMed  Google Scholar 

  • Mohan GC, Silverberg JI (2015) Association of vitiligo and alopecia areata with atopic dermatitis: a systematic review and meta-analysis. JAMA Dermatol 151(5):522–528

    PubMed  Google Scholar 

  • Murray C, Vos T, Lozano R, AlMazroa MA, Memish ZA (2014) Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the global burden of disease study 2010, vol 380. pp 2197, 2012

    Google Scholar 

  • Nagpal R, Wang S, Ahmadi S, Hayes J, Gagliano J, Subashchandrabose S, Kitzman DW, Becton T, Read R, Yadav H (2018) Human-origin probiotic cocktail increases short-chain fatty acid production via modulation of mice and human gut microbiome. Sci Rep 8(1):1–15

    Google Scholar 

  • Nakatsuji T, Chen TH, Narala S, Chun KA, Two AM, Yun T, Shafiq F, Kotol PF, Bouslimani A, Melnik AV (2017) Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis. Sci Trans Med 9(378):eaah4680

    Google Scholar 

  • Nwanodi O (2018) Skin protective nutraceuticals: the current evidence in brief. In: Healthcare, vol 2. Multidisciplinary Digital Publishing Institute, p 40

    Google Scholar 

  • Nylund L, Nermes M, Isolauri E, Salminen S, De Vos W, Satokari R (2015) Severity of atopic disease inversely correlates with intestinal microbiota diversity and butyrate-producing bacteria. Allergy 70(2):241–244

    CAS  PubMed  Google Scholar 

  • Oh J, Freeman AF, Park M, Sokolic R, Candotti F, Holland SM, Segre JA, Kong HH, Program NCS (2013) The altered landscape of the human skin microbiome in patients with primary immunodeficiencies. Genome Res 23(12):2103–2114

    CAS  PubMed  PubMed Central  Google Scholar 

  • Olszak T, An D, Zeissig S, Vera MP, Richter J, Franke A, Glickman JN, Siebert R, Baron RM, Kasper DL (2012) Microbial exposure during early life has persistent effects on natural killer T cell function. Science 336(6080):489–493

    CAS  PubMed  PubMed Central  Google Scholar 

  • Penders J, Thijs C, van den Brandt PA, Kummeling I, Snijders B, Stelma F, Adams H, van Ree R, Stobberingh EE (2007) Gut microbiota composition and development of atopic manifestations in infancy: the KOALA birth cohort study. Gut 56(5):661–667

    CAS  PubMed  Google Scholar 

  • Penders J, Gerhold K, Stobberingh EE, Thijs C, Zimmermann K, Lau S, Hamelmann E (2013) Establishment of the intestinal microbiota and its role for atopic dermatitis in early childhood. J Allergy Clin Immunol 132(3):601–607.e608

    PubMed  Google Scholar 

  • Pols TW, Puchner T, Korkmaz HI, Vos M, Soeters MR, de Vries CJ (2017) Lithocholic acid controls adaptive immune responses by inhibition of Th1 activation through the vitamin D receptor. PLoS One 12(5)

    Google Scholar 

  • Reichardt N, Duncan SH, Young P, Belenguer A, Leitch CM, Scott KP, Flint HJ, Louis P (2014) Phylogenetic distribution of three pathways for propionate production within the human gut microbiota. ISME J 8(6):1323–1335

    CAS  PubMed  PubMed Central  Google Scholar 

  • Ridlon JM, Kang D-J, Hylemon PB (2006) Bile salt biotransformations by human intestinal bacteria. J Lipid Res 47(2):241–259

    CAS  PubMed  Google Scholar 

  • Ruan Y, Sun J, He J, Chen F, Chen R, Chen H (2015) Effect of probiotics on glycemic control: a systematic review and meta-analysis of randomized, controlled trials. PLoS One 10(7)

    Google Scholar 

  • Rusu E, Enache G, Cursaru R, Alexescu A, Radu R, Onila O, Cavallioti T, Rusu F, Posea M, Jinga M (2019) Prebiotics and probiotics in atopic dermatitis. Exp Ther Med 18(2):926–931

    CAS  PubMed  PubMed Central  Google Scholar 

  • Salem I, Ramser A, Isham N, Ghannoum MA (2018) The gut microbiome as a major regulator of the gut-skin axis. Front Microbiol 9:1459

    PubMed  PubMed Central  Google Scholar 

  • Schmitt J, Schwarz K, Baurecht H, Hotze M, Fölster-Holst R, Rodríguez E, Lee YA, Franke A, Degenhardt F, Lieb W (2016) Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes. J Allergy Clin Immunol 137(1):130–136

    PubMed  Google Scholar 

  • Sevelsted A, Stokholm J, Bønnelykke K, Bisgaard H (2015) Cesarean section and chronic immune disorders. Pediatrics 135(1):e92–e98

    PubMed  Google Scholar 

  • Shi B, Bangayan NJ, Curd E, Taylor PA, Gallo RL, Leung DY, Li H (2016) The skin microbiome is different in pediatric versus adult atopic dermatitis. J Allergy Clin Immunol 138(4):1233–1236

    PubMed  PubMed Central  Google Scholar 

  • Smith PM, Howitt MR, Panikov N, Michaud M, Gallini CA, Bohlooly-Y M, Glickman JN, Garrett WS (2013) The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science 341(6145):569–573

    CAS  PubMed  Google Scholar 

  • Song H, Yoo Y, Hwang J, Na Y-C, Kim HS (2016) Faecalibacterium prausnitzii subspecies–level dysbiosis in the human gut microbiome underlying atopic dermatitis. J Allergy Clin Immunol 137(3):852–860

    CAS  PubMed  Google Scholar 

  • Tatu AL, Ionescu MA, Clatici VG, Cristea VC (2016) Bacillus cereus strain isolated from Demodex folliculorum in patients with topical steroid-induced rosaceiform facial dermatitis. An Bras Dermatol 91(5):676–678

    PubMed  PubMed Central  Google Scholar 

  • Thorburn AN, Macia L, Mackay CR (2014) Diet, metabolites, and “western-lifestyle” inflammatory diseases. Immunity 40(6):833–842

    CAS  PubMed  Google Scholar 

  • Torii S, Torii A, Itoh K, Urisu A, Terada A, Fujisawa T, Yamada K, Suzuki H, Ishida Y, Nakamura F (2011) Effects of oral administration of lactobacillus acidophilus L-92 on the symptoms and serum markers of atopic dermatitis in children. Int Arch Allergy Immunol 154(3):236–245

    PubMed  Google Scholar 

  • Uhde M, Ajamian M, Caio G, De Giorgio R, Indart A, Green PH, Verna EC, Volta U, Alaedini A (2016) Intestinal cell damage and systemic immune activation in individuals reporting sensitivity to wheat in the absence of coeliac disease. Gut 65(12):1930–1937

    CAS  PubMed  Google Scholar 

  • van Nimwegen FA, Penders J, Stobberingh EE, Postma DS, Koppelman GH, Kerkhof M, Reijmerink NE, Dompeling E, van den Brandt PA, Ferreira I (2011) Mode and place of delivery, gastrointestinal microbiota, and their influence on asthma and atopy. J Allergy Clin Immunol 128(5):948–955.e943

    PubMed  Google Scholar 

  • Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S, Aboyans V (2012) Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the global burden of disease study 2010. Lancet 380(9859):2163–2196

    PubMed  PubMed Central  Google Scholar 

  • Waldman AR, Ahluwalia J, Udkoff J, Borok JF, Eichenfield LF (2018) Atopic dermatitis. Pediatr Rev 39(4):180–193. https://doi.org/10.1542/pir.2016-0169

    Article  PubMed  Google Scholar 

  • Wallach D, Taïeb A (2014) Atopic dermatitis/atopic eczema. In: Karger Publishers (ed) History of allergy, vol 100, pp 81–96

    Google Scholar 

  • Wang IJ, Wang JY (2015) Children with atopic dermatitis show clinical improvement after lactobacillus exposure. Clin Exp Allergy 45(4):779–787

    CAS  PubMed  Google Scholar 

  • Weidinger S, Novak N (2016) Atopic dermatitis. Lancet 387(10023):1109–1122

    PubMed  Google Scholar 

  • Williams H, Stewart A, von Mutius E, Cookson W, Anderson HR, of Asthma IS (2008) Is eczema really on the increase worldwide? J Allergy Clin Immunol 121(4):947–954.e915

    PubMed  Google Scholar 

  • Woo S-I, Kim J-Y, Lee Y-J, Kim N-S, Hahn Y-S (2010) Effect of lactobacillus sakei supplementation in children with atopic eczema–dermatitis syndrome. Ann Allergy Asthma Immunol 104(4):343–348

    CAS  PubMed  Google Scholar 

  • Yokoyama S, Hiramoto K, Koyama M, Ooi K (2015) Impairment of skin barrier function via cholinergic signal transduction in a dextran sulphate sodium-induced colitis mouse model. Exp Dermatol 24(10):779–784

    CAS  PubMed  Google Scholar 

  • Zeng M, Inohara N, Nuñez G (2017) Mechanisms of inflammation-driven bacterial dysbiosis in the gut. Mucosal Immunol 10(1):18–26

    CAS  PubMed  Google Scholar 

  • Zhang A, Silverberg JI (2015) Association of atopic dermatitis with being overweight and obese: a systematic review and metaanalysis. J Am Acad Dermatol 72(4):606–616.e604

    PubMed  Google Scholar 

  • Zheng J, Feng Q, Zheng S, Xiao X (2018) The effects of probiotics supplementation on metabolic health in pregnant women: An evidence based meta-analysis. PLoS One 13(5)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India

    Nikita Khanna, Anil Kumar & Sandip V. Pawar

  2. Department of Biological Sciences and Bioengineering, Indian institute of Technology, Kanpur, Uttar Pradesh, India

    Priyanka Devi

Authors
  1. Nikita Khanna
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Priyanka Devi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Anil Kumar
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sandip V. Pawar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sandip V. Pawar .

Editor information

Editors and Affiliations

  1. University Institute of Pharmaceutical Sciences, Chandigarh, Punjab, India

    Sandip V. Pawar

  2. Department of Microbiology, Panjab University, Chandigarh, Punjab, India

    Praveen Rishi

Rights and permissions

Reprints and permissions

Copyright information

© 2021 The Author(s), under exclusive licence to Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Khanna, N., Devi, P., Kumar, A., Pawar, S.V. (2021). Probiotics for Atopic Dermatitis. In: Pawar, S.V., Rishi, P. (eds) Probiotic Research in Therapeutics. Springer, Singapore. https://doi.org/10.1007/978-981-33-6236-9_15

Download citation

Publish with us

Policies and ethics

Search

Navigation