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Designing Probiotics and Its Clinical Applications

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Probiotic Research in Therapeutics

Abstract

Probiotics are health beneficial microorganisms which may improve the disturbed gut microflora and gut disease condition. Various probiotic preparations are available as health supplements in the market. Due to advancements in modern recombinant DNA technology and molecular biology techniques, alteration of DNA is possible. By using the above-mentioned techniques, probiotics can be improved in a number of ways, such as robustness and stress tolerance. Designer probiotics are ought to target enteric infections via obstruction of host-pathogenic ligand–receptor interactions. The probiotic’s interaction with the host cell receptors can be used as a tool for targeting infections. Recently, their clinical applications have been exploited in various therapeutic areas such as vaccines. Various microbial genera and their species used as probiotics are Lactobacillus, Bifidobacterium, Escherichia, Bacillus, and Streptococcus. Probiotics have shown clinical applications in Helicobacter pylori infections, inflammatory bowel disease, antibiotic associated diarrhea, ulcerative colitis, and allergy. There are various applications of designer probiotics, such as in the treatment of enteric infections, inflammatory bowel disease, diarrhea, dysentery, etc. Designer probiotics are emerging in the area of treatment of therapeutic diseases. In this chapter, various clinical applications of these probiotics are discussed, such as immune related diseases, enteric infections, HIV infection, microbial infections, cancer, etc.

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  1. Department of Pharmaceutical Technology (Biotechnology), National Institute of Pharmaceutical Education and Research (NIPER), S. A. S. Nagar, Punjab, India

    Akash P. Kanadje & Uttam C. Banerjee

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  1. Akash P. Kanadje
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Correspondence to Uttam C. Banerjee .

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  1. University Institute of Pharmaceutical Sciences, Chandigarh, Punjab, India

    Sandip V. Pawar

  2. Department of Microbiology, Panjab University, Chandigarh, Punjab, India

    Praveen Rishi

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Kanadje, A.P., Banerjee, U.C. (2021). Designing Probiotics and Its Clinical Applications. In: Pawar, S.V., Rishi, P. (eds) Probiotic Research in Therapeutics. Springer, Singapore. https://doi.org/10.1007/978-981-33-6236-9_10

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