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Natural Polymers in Pharmaceutical Nanotechnology

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Nanomaterials and Nanotechnology

Part of the book series: Materials Horizons: From Nature to Nanomaterials ((MHFNN))

Abstract

The use of natural polymers for the release of drugs is attractive due to biodegradability, biocompatibility, inexpensive, chemically modifiable, in addition to secondary properties such as high swelling capacity, bioadhesion, offering positive electric charges, and stimulus-sensitive factors such as pH and temperature. The present work proposes a critical approach to the state of the art on the applications of natural polymers for the release of drugs, and the manufacture of nanoparticles, including advantages and limitations. We also address the vectorization analysis of nanoparticles elaborated with natural polymers, and we emphasize the application of nanoparticles for gene therapy. Finally, due to the nature of nanoparticle fabrication and disposition, we included a section called “Special requirements in the characterization of excipients and nanoparticles fabricated with natural polymers” aimed to recommend a physicochemical characterization that guarantees the adequate reproducibility of the formulations, one of the great paradigms in the development of nanoparticles elaborated with natural polymers. Finally, we present a section denominated “Nanotoxicology of natural polymers used in the pharmaceutical area.” We mention specific cases of the limitations in this type of excipient, although we also highlight new and better properties that can be exploited.

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Authors and Affiliations

  1. Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, 04510, Mexico City, Mexico

    G. Leyva-Gómez & M. L. Del Prado-Audelo

  2. Laboratorio de Farmacia, Facultad de Ciencias Químicas, Universidad de Colima, 28400, Colima, Mexico

    N. Mendoza-Muñoz

  3. Laboratorio de Posgrado en Tecnología Farmacéutica, Universidad Nacional Autónoma de México, FES-Cuautitlán, 54740, Cuautitlán Izcalli, Edo. de Mexico, Mexico

    M. L. Del Prado-Audelo & D. Quintanar-Guerrero

  4. Laboratorio de Procesos de Transformación y Tecnologías Emergentes En Alimentos, Universidad Nacional Autónoma de México, FES-Cuautitlán, 54714, Cuautitlán Izcalli, Edo. de México, Mexico

    S. A. Ojeda-Piedra & M. L. Zambrano-Zaragoza

  5. Escuela de Ingeniería y Ciencias, Departamento de Bioingeniería, Tecnológico de Monterrey Campus Ciudad de México, 14380, Ciudad de México, Mexico

    M. L. Del Prado-Audelo

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  1. G. Leyva-Gómez
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  6. D. Quintanar-Guerrero
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Correspondence to D. Quintanar-Guerrero .

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  1. Department of Analytical Chemistry and Physical Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil

    Ronaldo Ferreira do Nascimento

  2. Department of Chemistry, State University of Ceará, Fortaleza, Ceará, Brazil

    Vicente de Oliveira Sousa Neto

  3. Department of Analytical Chemistry and Physical Chemistry, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil

    Pierre Basílio Almeida Fechine

  4. Department of Physics, Federal University of Ceará, Fortaleza, Ceará, Brazil

    Paulo de Tarso Cavalcante Freire

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Leyva-Gómez, G., Mendoza-Muñoz, N., Del Prado-Audelo, M.L., Ojeda-Piedra, S.A., Zambrano-Zaragoza, M.L., Quintanar-Guerrero, D. (2021). Natural Polymers in Pharmaceutical Nanotechnology. In: Nascimento, R.F.d., Neto, V.d.O.S., Fechine, P.B.A., Freire, P.d.T.C. (eds) Nanomaterials and Nanotechnology. Materials Horizons: From Nature to Nanomaterials. Springer, Singapore. https://doi.org/10.1007/978-981-33-6056-3_6

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