Abstract
For thousands of years, tremendous amount of research has been carried out to understand one of the leading causes of death – cancer. Being known for its complexity, researchers have put tremendous efforts in acquiring every bit of knowledge that is required to understand the distinct aspects of tumor biology, progression, invasion, and metastasis. These include understanding the tumor physiology, developing different detection techniques, as well as identifying the genetic roots of the disease. This in turn would help in unraveling the signaling circuitry that regulates intercommunication within the tumor microenvironment. The main objective of this chapter is to provide a comprehensive overview of the different historic events that have taken place in the field of cancer research. Besides, it also briefly describes the different hallmarks of cancer that have been put forth to elaborate the different mechanisms adapted by cancer cells for their survival and progression.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Benner J (2015) The history of cancer: a timeline [Online]. The rector and visitors of the University of Virginia. Available: https://blog.uvahealth.com/2015/03/12/history-cancer-timeline/. Accessed 10 Aug 2018
Emory University Historical cancer highlights, CancerQuest
Frank DA (2011) Signaling pathways in cancer pathogenesis and therapy. Springer, New York
Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57–70
Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646–674
Hunter T, Sefton BM (1980) Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. Proc Natl Acad Sci U S A 77:1311–1315
National Cancer Institute (2015) Milestones in cancer research and discovery [Online]. Available: https://www.cancer.gov/research/progress/250-years-milestones. Accessed 10 Aug 2018
Sudhakar A (2009) History of cancer, ancient and modern treatment methods. J Cancer Sci Ther 1:1–4
The history of cancer [Online]. Available: http://cancerfilms.org/timeline/. Accessed 10 Aug 2018
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Parui, A.L., Bose, K. (2019). Cancer Biology and Its Treatment Modalities: A Brief Historical Perspective. In: Bose, K., Chaudhari, P. (eds) Unravelling Cancer Signaling Pathways: A Multidisciplinary Approach. Springer, Singapore. https://doi.org/10.1007/978-981-32-9816-3_1
Download citation
DOI: https://doi.org/10.1007/978-981-32-9816-3_1
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-32-9815-6
Online ISBN: 978-981-32-9816-3
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)