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Cellular and Molecular Mechanisms of Hypertrophic Scarring

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Total Scar Management

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Abstract

Scarring is a natural response following wound healing and includes mature and pathological scars. Pathological scars such as hypertrophic scars (HTS) and keloids are commonly seen in burns and other traumatic injuries to the deep dermis of the skin. HTS are hypervascular, red, raised, and pruritic scars, which are normally confined to the boundary of the original injury, and can remodel into mature scars but often over prolonged periods of time. The development of HTS can lead to physical disfigurement, contractures, and loss of function. Despite many treatment options, there are no modalities available for the prevention or complete reversal of scar formation. Therefore, an updated cellular and molecular understanding of the pathophysiology of HTS is important in order to develop promising novel therapies that can benefit the patients and their care-providers.

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Authors and Affiliations

  1. Wound Healing Research Group, Department of Surgery, University of Alberta, Edmonton, AB, Canada

    Antoinette T. Nguyen, Jie Ding & Edward E. Tredget

  2. Division of Plastic and Reconstructive Surgery and Critical Care, Department of Surgery, University of Alberta, Edmonton, AB, Canada

    Edward E. Tredget

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  1. Antoinette T. Nguyen
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  2. Jie Ding
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  3. Edward E. Tredget
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Correspondence to Edward E. Tredget .

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  1. Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, Tokyo, Japan

    Rei Ogawa

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Nguyen, A.T., Ding, J., Tredget, E.E. (2020). Cellular and Molecular Mechanisms of Hypertrophic Scarring. In: Ogawa, R. (eds) Total Scar Management. Springer, Singapore. https://doi.org/10.1007/978-981-32-9791-3_3

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