Translational and Reverse Pharmacology

Abstract

Translational pharmacology is the branch of pharmacology that deals with the application of results from molecular and preclinical research into clinical practice. Translational pharmacology aims to reduce the high failure rate of drug development process, thereby reducing the cost and time required for bringing a new drug to the market. It does this by elucidating the target properly, improving the predictive value of early preclinical trials and optimizing dose selection. Reverse pharmacology is the field of drug discovery where the drug targets which might act as critical intervention points in the pathogenic process of diseases are first identified and characterized. Reverse pharmacology aims to characterize the target first and fish for an appropriate ligand.