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Gastric Cancer

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Helicobacter pylori

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Abstract

Because gastric cancer develops only in a very small portion of Helicobacter pylori (H. pylori)-infected population and it takes a very long time from H. pylori infection to gastric carcinogenesis, it is very difficult to prospectively demonstrate the effect of H. pylori eradication on the incidence of gastric cancer. Nevertheless, the individual studies and meta-analyses to date suggest that H. pylori eradication can reduce the relative risk for gastric cancer to approximately two-thirds. Guidelines all over the world also consistently recommend H. pylori eradication as an effective strategy for prevention of gastric cancer. However, there are still controversies regarding when the optimal timing for H. pylori eradication is and whether we have to treat H. pylori infection in all asymptomatic healthy population to prevent gastric cancer. In addition, it is clear that H. pylori eradication cannot prevent all gastric cancers. Therefore, after H. pylori eradication, we have to consider additional surveillance in patients who have family history of gastric cancer or who have precancerous lesions such as atrophic gastritis or intestinal metaplasia.

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Authors and Affiliations

  1. Department of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumi-ro 173 beon-gil, Bundang-gu, Seongnam, Gyeonggi-do, 13620, South Korea

    Hyuk Yoon MD

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  1. Hyuk Yoon MD
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Correspondence to Hyuk Yoon MD .

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Editors and Affiliations

  1. Seoul National University, Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea (Republic of)

    Nayoung Kim

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© 2016 Springer Science+Business Media Singapore

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Yoon, H. (2016). Gastric Cancer. In: Kim, N. (eds) Helicobacter pylori. Springer, Singapore. https://doi.org/10.1007/978-981-287-706-2_53

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  • DOI: https://doi.org/10.1007/978-981-287-706-2_53

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-287-705-5

  • Online ISBN: 978-981-287-706-2

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