Skip to main content

Probiotics

  • Chapter
  • First Online:
Helicobacter pylori
  • 1972 Accesses

Abstract

Various microorganisms are used as probiotics of which lactic acid-producing bacteria such as Lactobacillus spp., Bifidobacterium spp., etc. are most commonly used. The effects of probiotics are carried out through immunological or nonimmunological mechanisms. Production of antibiotic substances, competition with Helicobacter pylori (H. pylori) for adhesion receptors, stimulation of mucin production, stabilization of the gut mucosal barrier, etc. are being suggested as nonimmunological mechanisms. Although improvement in H. pylori eradication rate, decrease in antibiotic-associated side effects, reduced H. pylori colonization, and decreased Helicobacter-induced gastritis are being reported in human studies with probiotics, further investigation is needed as results are shown to differ among studies.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Franceschi F, Cazzato A, Nista EC, Scarpellini E, Roccarina D, Gigante G, et al. Role of probiotics in patients with Helicobacter pylori infection. Helicobacter. 2007;12 Suppl 2:59–63.

    Article  PubMed  Google Scholar 

  2. Felley C, Michetti P. Probiotics and Helicobacter pylori. Best Pract Res Clin Gastroenterol. 2003;17:785–91.

    Article  CAS  PubMed  Google Scholar 

  3. Vitor JM, Vale FF. Alternative therapies for Helicobacter pylori: probiotics and phytomedicine. FEMS Immunol Med Microbiol. 2011;63:153–64.

    Article  CAS  PubMed  Google Scholar 

  4. Patel A, Shah N, Prajapati JB. Clinical application of probiotics in the treatment of Helicobacter pylori infection-a brief review. J Microbiol Immunol Infect. 2014;47:429–37.

    Article  PubMed  Google Scholar 

  5. Haller D, Bode C, Hammes WP, Pfeifer AM, Schiffrin EJ, Blum S. Non-pathogenic bacteria elicit a differential cytokine response by intestinal epithelial cell/leucocyte co-cultures. Gut. 2000;47:79–87.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Saxelin M, Tynkkynen S, Mattila-Sandholm T, de Vos WM. Probiotic and other functional microbes: from markets to mechanisms. Curr Opin Biotechnol. 2005;16:204–11.

    Article  CAS  PubMed  Google Scholar 

  7. Perdigòn G, Medina M, Vintiñi E, Valdez JC. Intestinal pathway of internalisation of lactic acid bacteria and gut mucosal immunostimulation. Int J Immunopathol Pharmacol. 2000;13:141–50.

    PubMed  Google Scholar 

  8. Gill HS. Probiotics to enhance anti-infective defences in the gastrointestinal tract. Best Pract Res Clin Gastroenterol. 2003;17:755–73.

    Article  CAS  PubMed  Google Scholar 

  9. Kabir AM, Aiba Y, Takagi A, Kamiya S, Miwa T, Koga Y. Prevention of Helicobacter pylori infection by Lactobacilli in a gnotobiotic murine model. Gut. 1997;41:49–55.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Sgouras D, Maragkoudakis P, Petraki K, Martinez-Gonzalez B, Eriotou E, Michopoulos S, et al. In vitro and in vivo inhibition of Helicobacter pylori by Lactobacillus casei strain Shirota. Appl Environ Microbiol. 2004;70:518–26.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Aiba Y, Suzuki N, Kabir AM, Takagi A, Koga Y. Lactic acid-mediated suppression of Helicobacter pylori by the oral administration of Lactobacillus salivarius as a probiotic in a gnotobiotic murine model. Am J Gastroenterol. 1998;93:2097–101.

    Article  CAS  PubMed  Google Scholar 

  12. Viljanen M, Savilahti E, Haahtela T, Juntunen-Backman K, Korpela R, Poussa T, et al. Probiotics in the treatment of atopic eczema/dermatitis syndrome in infants: a double-blind placebo-controlled trial. Allergy. 2005;60:494–500.

    Article  CAS  PubMed  Google Scholar 

  13. Yang YJ, Chuang CC, Yang HB, Lu CC, Sheu BS. Lactobacillus acidophilus ameliorates H. pylori-induced gastric inflammation by inactivating the Smad7 and NFkappaB pathways. BMC Microbiol. 2012;12:38.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Lesbros-Pantoflickova D, Corthésy-Theulaz I, Blum AL. Helicobacter pylori and probiotics. J Nutr. 2007;137:812s–8s.

    CAS  PubMed  Google Scholar 

  15. Servin AL. Antagonistic activities of Lactobacilli and Bifidobacteria against microbial pathogens. FEMS Microbiol Rev. 2004;28:405–40.

    Article  CAS  PubMed  Google Scholar 

  16. Jack RW, Tagg JR, Ray B. Bacteriocins of gram-positive bacteria. Microbiol Rev. 1995;59:171–200.

    CAS  PubMed  PubMed Central  Google Scholar 

  17. Klaenhammer TR. Genetics of bacteriocins produced by lactic acid bacteria. FEMS Microbiol Rev. 1993;12:39–85.

    Article  CAS  PubMed  Google Scholar 

  18. Nam H, Ha M, Bae O, Lee Y. Effect of Weissella confusa strain pl9001 on the adherence and growth of Helicobacter pylori. Appl Environ Microbiol. 2002;68:4642–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Byrd JC, Yunker CK, Xu QS, Sternberg LR, Bresalier RS. Inhibition of gastric mucin synthesis by Helicobacter pylori. Gastroenterology. 2000;118:1072–9.

    Article  CAS  PubMed  Google Scholar 

  20. Mack DR, Ahrne S, Hyde L, Wei S, Hollingsworth MA. Extracellular MUC3 mucin secretion follows adherence of Lactobacillus strains to intestinal epithelial cells in vitro. Gut. 2003;52:827–33.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Mattar AF, Teitelbaum DH, Drongowski RA, Yongyi F, Harmon CM, Coran AG. Probiotics up-regulate MUC-2 mucin gene expression in a Caco-2 cell-culture model. Pediatr Surg Int. 2002;18:586–90.

    Article  CAS  PubMed  Google Scholar 

  22. Johnson-Henry KC, Mitchell DJ, Avitzur Y, Galindo-Mata E, Jones NL, Sherman PM. Probiotics reduce bacterial colonization and gastric inflammation in H. pylori-infected mice. Dig Dis Sci. 2004;49:1095–102.

    Article  PubMed  Google Scholar 

  23. Brzozowski T, Konturek PC, Mierzwa M, Drozdowicz D, Bielanski W, Kwiecien S, et al. Effect of probiotics and triple eradication therapy on the cyclooxygenase (COX)-2 expression, apoptosis, and functional gastric mucosal impairment in Helicobacter pylori-infected mongolian gerbils. Helicobacter. 2006;11:10–20.

    Article  CAS  PubMed  Google Scholar 

  24. Sgouras DN, Panayotopoulou EG, Martinez-Gonzalez B, Petraki K, Michopoulos S, Mentis A. Lactobacillus johnsonii LA1 attenuates Helicobacter pylori-associated gastritis and reduces levels of proinflammatory chemokines in c57bl/6 mice. Clin Diagn Lab Immunol. 2005;12:1378–86.

    CAS  PubMed  PubMed Central  Google Scholar 

  25. Ushiyama A, Tanaka K, Aiba Y, Shiba T, Takagi A, Mine T, et al. Lactobacillus gasseri OLL2716 as a probiotic in clarithromycin-resistant Helicobacter pylori infection. J Gastroenterol Hepatol. 2003;18:986–91.

    Article  PubMed  Google Scholar 

  26. Chen X, Liu XM, Tian F, Zhang Q, Zhang HP, Zhang H, et al. Antagonistic activities of Lactobacilli against Helicobacter pylori growth and infection in human gastric epithelial cells. J Food Sci. 2012;77:M9–14.

    Article  CAS  PubMed  Google Scholar 

  27. Hwang SW, Kim N, Kim JM, Huh CS, Ahn YT, Park SH, et al. Probiotic suppression of the H. pylori-induced responses by conjugated linoleic acids in a gastric epithelial cell line. Prostaglandins Leukot Essent Fatty Acids. 2012;86:225–31.

    Article  CAS  PubMed  Google Scholar 

  28. Ojetti V, Bruno G, Ainora ME, Gigante G, Rizzo G, Roccarina D, et al. Impact of Lactobacillus reuteri supplementation on anti-Helicobacter pylori levofloxacin-based second-line therapy. Gastroenterol Res Pract. 2012;2012:740381.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Yoon H, Kim N, Kim JY, Park SY, Park JH, Jung HC, et al. Effects of multistrain probiotic-containing yogurt on second-line triple therapy for Helicobacter pylori infection. J Gastroenterol Hepatol. 2011;26:44–8.

    Article  PubMed  Google Scholar 

  30. Kim MN, Kim N, Lee SH, Park YS, Hwang JH, Kim JW, et al. The effects of probiotics on PPI-triple therapy for Helicobacter pylori eradication. Helicobacter. 2008;13:261–8.

    Article  CAS  PubMed  Google Scholar 

  31. Tursi A, Brandimarte G, Giorgetti GM, Modeo ME. Effect of Lactobacillus casei supplementation on the effectiveness and tolerability of a new second-line 10-day quadruple therapy after failure of a first attempt to cure Helicobacter pylori infection. Med Sci Monit. 2004;10:Cr662–6.

    PubMed  Google Scholar 

  32. Cremonini F, Di Caro S, Covino M, Armuzzi A, Gabrielli M, Santarelli L, et al. Effect of different probiotic preparations on anti-Helicobacter pylori therapy-related side effects: a parallel group, triple blind, placebo-controlled study. Am J Gastroenterol. 2002;97:2744–9.

    Article  PubMed  Google Scholar 

  33. Armuzzi A, Cremonini F, Ojetti V, Bartolozzi F, Canducci F, Candelli M, et al. Effect of Lactobacillus GG supplementation on antibiotic-associated gastrointestinal side effects during Helicobacter pylori eradication therapy: a pilot study. Digestion. 2001;63:1–7.

    Article  CAS  PubMed  Google Scholar 

  34. Canducci F, Armuzzi A, Cremonini F, Cammarota G, Bartolozzi F, Pola P, et al. A lyophilized and inactivated culture of Lactobacillus acidophilus increases Helicobacter pylori eradication rates. Aliment Pharmacol Ther. 2000;14:1625–9.

    Article  CAS  PubMed  Google Scholar 

  35. Francavilla R, Lionetti E, Castellaneta SP, Magistà AM, Maurogiovanni G, Bucci N, et al. Inhibition of Helicobacter pylori infection in humans by Lactobacillus reuteri ATCC 55730 and effect on eradication therapy: a pilot study. Helicobacter. 2008;13:127–34.

    Article  PubMed  Google Scholar 

  36. Miki K, Urita Y, Ishikawa F, Iino T, Shibahara-Sone H, Akahoshi R, et al. Effect of Bifidobacterium bifidum fermented milk on Helicobacter pylori and serum pepsinogen levels in humans. J Dairy Sci. 2007;90:2630–40.

    Article  CAS  PubMed  Google Scholar 

  37. Wang KY, Li SN, Liu CS, Perng DS, Su YC, Wu DC, et al. Effects of ingesting Lactobacillus- and Bifidobacterium-containing yogurt in subjects with colonized Helicobacter pylori. Am J Clin Nutr. 2004;80:737–41.

    CAS  PubMed  Google Scholar 

  38. Pantoflickova D, Corthésy-Theulaz I, Dorta G, Stolte M, Isler P, Rochat F, et al. Favourable effect of regular intake of fermented milk containing Lactobacillus johnsonii on Helicobacter pylori associated gastritis. Aliment Pharmacol Ther. 2003;18:805–13.

    Article  CAS  PubMed  Google Scholar 

  39. Felley CP, Corthésy-Theulaz I, Rivero JL, Sipponen P, Kaufmann M, Bauerfeind P, et al. Favourable effect of an acidified milk (LC-1) on Helicobacter pylori gastritis in man. Eur J Gastroenterol Hepatol. 2001;13:25–9.

    Article  CAS  PubMed  Google Scholar 

  40. Sheu BS, Wu JJ, Lo CY, Wu HW, Chen JH, Lin YS, et al. Impact of supplement with Lactobacillus- and Bifidobacterium-containing yogurt on triple therapy for Helicobacter pylori eradication. Aliment Pharmacol Ther. 2002;16:1669–75.

    Article  PubMed  Google Scholar 

  41. Mrda Z, Zivanović M, Rasić J, Gajin S, Somer L, Trbojević S, et al. Therapy of Helicobacter pylori infection using Lactobacillus acidophilus. Med Pregl. 1998;51:343–5.

    CAS  PubMed  Google Scholar 

  42. Armuzzi A, Cremonini F, Bartolozzi F, Canducci F, Candelli M, Ojetti V, et al. The effect of oral administration of Lactobacillus GG on antibiotic-associated gastrointestinal side-effects during Helicobacter pylori eradication therapy. Aliment Pharmacol Ther. 2001;15:163–9.

    Article  CAS  PubMed  Google Scholar 

  43. Lionetti E, Miniello VL, Castellaneta SP, Magistà AM, de Canio A, Maurogiovanni G, et al. Lactobacillus reuteri therapy to reduce side-effects during anti-Helicobacter pylori treatment in children: a randomized placebo controlled trial. Aliment Pharmacol Ther. 2006;24:1461–8.

    Article  CAS  PubMed  Google Scholar 

  44. Sýkora J, Valecková K, Amlerová J, Siala K, Dedek P, Watkins S, et al. Effects of a specially designed fermented milk product containing probiotic Lactobacillus casei DN-114 001 and the eradication of H. pylori in children: a prospective randomized double-blind study. J Clin Gastroenterol. 2005;39:692–8.

    Article  PubMed  Google Scholar 

  45. Michetti P, Dorta G, Wiesel PH, Brassart D, Verdu E, Herranz M, et al. Effect of whey-based culture supernatant of Lactobacillus acidophilus (johnsonii) La1 on Helicobacter pylori infection in humans. Digestion. 1999;60:203–9.

    Article  CAS  PubMed  Google Scholar 

  46. Imase K, Tanaka A, Tokunaga K, Sugano H, Ishida H, Takahashi S. Lactobacillus reuteri tablets suppress Helicobacter pylori infection – a double-blind randomised placebo-controlled cross-over clinical study. Kansenshogaku Zasshi. 2007;81:387–93.

    Article  PubMed  Google Scholar 

  47. Makelainen H, Tahvonen R, Salminen S, Ouwehand AC. In vivo safety assessment of two Bifidobacterium longum strains. Microbiol Immunol. 2003;47:911–4.

    Article  PubMed  Google Scholar 

  48. Besselink MG, van Santvoort HC, Buskens E, Boermeester MA, van Goor H, Timmerman HM, et al. Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial. Lancet. 2008;371:651–9.

    Article  PubMed  Google Scholar 

  49. Salminen MK, Rautelin H, Tynkkynen S, Poussa T, Saxelin M, Valtonen V, et al. Lactobacillus bacteremia, species identification, and antimicrobial susceptibility of 85 blood isolates. Clin Infect Dis. 2006;42:e35–44.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Sung Wook Hwang MD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer Science+Business Media Singapore

About this chapter

Cite this chapter

Hwang, S.W. (2016). Probiotics. In: Kim, N. (eds) Helicobacter pylori. Springer, Singapore. https://doi.org/10.1007/978-981-287-706-2_47

Download citation

  • DOI: https://doi.org/10.1007/978-981-287-706-2_47

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-287-705-5

  • Online ISBN: 978-981-287-706-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics