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Biodegradable Thermogelling Poly(Organophosphazenes) and Their Potential Biomedical Applications

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In-Situ Gelling Polymers

Part of the book series: Series in BioEngineering ((SERBIOENG))

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Abstract

Poly(organophosphazenes) as a new type of biodegradable polymers have been exploited as carriers for various drug delivery systems due to versatility of molecular structures and easily modulated physico-chemical properties. Thus, biodegradable thermogelling poly(organophosphazenes) are expected to be very promising biomaterials as injectable systems with minimal surgical intervention for drug delivery and tissue engineering applications. The key advantage of thermosensitive hydrogels based on poly(organophosphazenes) over other thermosensitive polymers is the ease of tuning the hydrogel properties by use of different compositions of side groups or through variations in co-substituent ratios. A variety of poly(organophosphazene) thermogels have been developed with desirable hydrophobic-hydrophilic balance, controllable degradation rate and suitable mechanical properties with respect to different applications. This chapter covers a comprehensive summary of the recent developments in this field of study, including polymer design, property assessment and potential biomedical applications.

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    Xiao Liu

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    Xian Jun Loh

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Liu, X. (2015). Biodegradable Thermogelling Poly(Organophosphazenes) and Their Potential Biomedical Applications. In: Loh, X. (eds) In-Situ Gelling Polymers. Series in BioEngineering. Springer, Singapore. https://doi.org/10.1007/978-981-287-152-7_3

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