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Theranostic Approaches for Diagnosis and Treatment of Cancer: An Update

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Targeted Cancer Therapy in Biomedical Engineering

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

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Abstract

Cancer is one of the most causes of disease-related mortality. One of the major causes of this has been the delay in diagnosis and considerable failure of therapeutic options for cancer. The failure is mainly due to frequent metastasis and a high degree of resistance. The simplest solution to the problem lies in either early diagnosis, efficacious therapy, or continuous monitoring. The identification of sensitive and reliable biomarkers for early screening and therapeutic monitoring has been a thrust area of research. The available alternative, despite the efforts, carries several limitations including high toxicity associated with current therapeutic agents and a high degree of genetic variability among cancer types. Thus, there is an unmet need for the development of safer therapeutic alternatives and better diagnostic methods. The field of theranostics has provided an important ray of hope for the advancement of breast cancer therapeutics. Theranostics deal with the targeting receptor for both therapeutic as well as diagnostic purposes. The field of theranostics has been efficiently complemented by the fields of nanomedicine and nuclear medicine. Various aptamers, antibodies, enzymes, and proteins have been conjugated and functionalized to form theranostic nanoparticles and radiopharmaceuticals with the patient-centric approach. The current chapter discusses the concepts and applications of theranostic approaches for the diagnosis and treatment of cancer with a focus on the recent advancement in the field.

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, DIPSAR, Delhi Pharmaceutical Sciences and Research University (DPSRU), New Delhi, India

    Ruhi Ali

  2. Department of Pharmacology, School of Pharmaceutical Education and Research (SPER), Jamia Hamdard, New Delhi, India

    Faraha Ahmed

  3. Govt of NCT of Delhi, Department of Pharmaceutics, DIPSAR, Delhi Pharmaceutical Sciences and Research University (DPSRU), Mehrauli-Badarpur Road, Pushp Vihar, New Delhi, 110017, India

    Meenakshi Kanwar Chauhan

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Correspondence to Meenakshi Kanwar Chauhan .

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  1. Department of Pharmacy, School of Medical and Allied Science, Galgotias University, Greater Noida, India

    Rishabha Malviya

  2. Department of Pharmacy, School of Medical and Allied Science, Galgotias University, Greater Noida,, India

    Sonali Sundram

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Ali, R., Ahmed, F., Chauhan, M. (2023). Theranostic Approaches for Diagnosis and Treatment of Cancer: An Update. In: Malviya, R., Sundram, S. (eds) Targeted Cancer Therapy in Biomedical Engineering. Biological and Medical Physics, Biomedical Engineering. Springer, Singapore. https://doi.org/10.1007/978-981-19-9786-0_18

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