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Chitosan Nanoparticles: A Potential Biomedical Device

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Chitosan Nanocomposites

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

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Abstract

Chitosan nanoparticles (chitosan-based nanoparticles; chitosan nanostructures; ChNPs) constitute a very interesting and promising group of bio-based compounds, which have attracted a lot of attention in the last decades. They are more and more commonly used in various biomedical devices, especially in cancer diagnostics (fluorescent endoscopic diagnostics, detecting cancer cells), wound dressings, as the glucose detection sensor and the histamine biosensor, in bone tissue engineering and dentistry, which are presented in details in this chapter. Such a variety of application possibilities is mainly due to the properties of chitosan, which is characterized by high biocompatibility, biodegradability, non-toxicity, as well as the great potential as nanocarriers encapsulating active substances and providing a controlled release process. This chapter presents an overview of ChNPs preparation methods, mainly: reversed micelles, emulsification and crosslinking, SCASA, spray drying, phase inversion precipitation, ionic gelation, and emulsion-droplet coalescence. Offering a lot of benefits, nanotechnology for medical and biomedical science has become the foundation for the development and improvement of human life. The safety of nanoparticles which can be toxic to the environment, organisms, and cells, had to be taken into account in their safety assessment in the biomedical fields. According to this, the overall safety of these materials is also evaluated.

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Authors and Affiliations

  1. Chair and Department of Pharmaceutical Botany, Medical College, Jagiellonian University, Medyczna 9, 30-688, Kraków, Poland

    Karolina Jafernik, Halina Ekiert & Agnieszka Szopa

  2. Faculty of Chemical Engineering and Technology, Institute of Organic Chemistry and Technology, Cracow University of Technology, Warszawska 24, 31-155, Kraków, Poland

    Magdalena Anna Malinowska, Katarzyna Bialik-Wąs, Marta Sharafan & Elżbieta Sikora

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  1. Karolina Jafernik
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  2. Magdalena Anna Malinowska
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Correspondence to Magdalena Anna Malinowska or Agnieszka Szopa .

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  1. Department of Chemistry, Veer Surendra Sai University of Technology, Burla, Sambalpur, Odisha, India

    Sarat Kumar Swain

  2. Department of Chemistry, Veer Surendra Sai University of Technology, Burla, Sambalpur, Odisha, India

    Anuradha Biswal

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Jafernik, K. et al. (2023). Chitosan Nanoparticles: A Potential Biomedical Device. In: Swain, S.K., Biswal, A. (eds) Chitosan Nanocomposites. Biological and Medical Physics, Biomedical Engineering. Springer, Singapore. https://doi.org/10.1007/978-981-19-9646-7_6

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