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Leishmaniasis: Tissue Tropism in Relation to the Species Diversity

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Pathobiology of Parasitic Protozoa: Dynamics and Dimensions

Abstract

Leishmania is a vector-borne, obligatory, and anaerobic protozoan parasite that causes a spectrum of clinical conditions in its hosts. The disease has several outcomes and targets different parts of the host body ranging from infection in the dermal to the visceral organs. The fate of this disease depends highly on the availability of specific drugs and their penetration into the precise location of pathogen residence. Unavailability of specific medicines can and has caused death worldwide. This decision of sustenance vs. remission depends on various factors such as initial encounters of the host immune system with the pathogen during entry and the level of dissemination allowed after that. This in turn highly depends on nutritional availability and safe residence for the parasite inside the host system and, hence, to be precise its tropism. Therefore, to understand disease pathogenesis, it is important to explore pathogen-host interactions in light of their tropism. This chapter discusses several manifestations following Leishmania invasion into their mammalian host and the factors responsible for them. We also summarize various exceptions and their possible reasons including both parasitic and host-related factors influencing different disease outcomes.

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Authors and Affiliations

  1. Cellular Immunology and Vector Molecular Biology Laboratory, Department of Zoology, West Bengal State University, Barasat, West Bengal, India

    Sanhita Ghosh, Supriya Nath, Kamalika Roy, Suman Karmakar & Chiranjib Pal

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  1. Sanhita Ghosh
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  2. Supriya Nath
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  3. Kamalika Roy
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Correspondence to Chiranjib Pal .

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Editors and Affiliations

  1. School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal, India

    Budhaditya Mukherjee

  2. Department of Microbiology, Adamas University, Jagannathpur, West Bengal, India

    Arijit Bhattacharya

  3. Johns Hopkins University, Baltimore, MD, USA

    Rupkatha Mukhopadhyay

  4. Federal University of Piauí, Piauí, Brazil

    Bruno Guedes Alcoforado Aguiar

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Ghosh, S., Nath, S., Roy, K., Karmakar, S., Pal, C. (2023). Leishmaniasis: Tissue Tropism in Relation to the Species Diversity. In: Mukherjee, B., Bhattacharya, A., Mukhopadhyay, R., Aguiar, B.G.A. (eds) Pathobiology of Parasitic Protozoa: Dynamics and Dimensions. Springer, Singapore. https://doi.org/10.1007/978-981-19-8225-5_7

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