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Xanthan Gum-Based Drug Delivery Systems for Respiratory Diseases

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Natural Polymeric Materials based Drug Delivery Systems in Lung Diseases

Abstract

Respiratory diseases such as acute respiratory syndrome (ARDS), asthma, lung cancer, and chronic obstructive pulmonary disease (COPD) have been associated with pulmonary inflammation. These illnesses are becoming a serious public health concern and a financial burden on the aging population. Anti-inflammatory medicines in different dosage forms are used to treat these diseases that minimize the risk of pulmonary inflammation. However, without the assistance of a suitable and potential drug carrier, which can transport the drug to the site of pharmacological action without losing the active component, is always a challenge for research scientists. Different drug carrier systems have been created to increase the efficacy in drug delivery systems, avoiding drug degradation during transit, avoiding harmful effects from fast release, and improved medication delivery to target areas. There has been a paradigm shift toward natural polymers because of the adverse effects of synthetic polymers. Nowadays, natural polymers are preferred as drug carriers over others due to various characteristics such as biocompatibility, nontoxicity, and biodegradability. Xanthan gum (XG) is a natural microbial polysaccharide having all the above-mentioned characteristics and can be excreted directly by the kidney or can be degraded into smaller molecules. This natural excipient has been investigated as a matrix for solid dosage forms (tablets, capsules), nanoparticles, microparticles, hydrogels, buccal/transdermal patches, and tissue engineering scaffolds with varying degrees of efficacy and distinctive rheological features. This chapter will provide recent updates about the role of xanthan gum-based drug delivery systems for respiratory diseases.

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Authors and Affiliations

  1. School of Pharmaceutical Sciences, MVN University, Palwal, Haryana, India

    Tarun Virmani, Girish Kumar, Reshu Virmani & Ashwani Sharma

  2. Faculty of Pharmacy, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India

    Kamla Pathak

Authors
  1. Tarun Virmani
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  2. Girish Kumar
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  3. Reshu Virmani
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  4. Ashwani Sharma
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  5. Kamla Pathak
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Editor information

Editors and Affiliations

  1. Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India

    Harish Dureja

  2. School of Public Health, University of Technology Sydney, Ultimo, NSW, Australia

    Jon Adams

  3. Drug Development and Innovation Centre, University of Alberta, Edmonton, AB, Canada

    Raimar Löbenberg

  4. School of Pharmaceutical Sciences, Universidade de São Paulo, São Paulo, Brazil

    Terezinha de Jesus Andreoli Pinto

  5. Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW, Australia

    Kamal Dua

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© 2023 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

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Virmani, T., Kumar, G., Virmani, R., Sharma, A., Pathak, K. (2023). Xanthan Gum-Based Drug Delivery Systems for Respiratory Diseases. In: Dureja, H., Adams, J., Löbenberg, R., Andreoli Pinto, T.d.J., Dua, K. (eds) Natural Polymeric Materials based Drug Delivery Systems in Lung Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-19-7656-8_16

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