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Correlation Between Reactive Oxygen Species and Synbiotics for Effective Treatment of Cancer

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Synbiotics for the Management of Cancer

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Abstract

Reactive oxygen species (ROS) are groups or categories of reactive molecules evolving through significant signaling pathways. Since all normal cells need a moderately lower level of ROS to function as mortal cells, even aside from functionality, ROS has been found to contribute on how genes are being expressed or over expressed. Many previous studies have only focused on ROS as metabolic end products of cellular respiration, containing oxygen molecules although with high reactivity. Recent studies have shown that increased cell respiration directed through hypoxia inducible factor (HIF) is a master oxygen beam regulating cell response to varying oxygen levels can reduce or increase ROS formation. It is evident that high level of ROS is observed in tumor cells, such an increase also contributes to tumor promotion, progression, and several pathological conditions of the cell. Synbiotics are described as the synergistic combination of probiotics and prebiotics. The formal is referred to as useful gut bacteria while the latter are nondigestible fibers which allow the proliferation of the gut microorganisms. Synbiotic can serve as antioxidant system since the native systems are generally not sufficient in preventing living organisms from oxidative stress. Probiotics as live nonpathogenic microbes in the presence of adequate prebiotics when administered in sufficient amount can confer microbial balance in the gastrointestinal tract which then upregulate the antioxidant activities of the host. Therefore, this chapter aims to elucidate the role of oxidative stress in cancer development. The potential modulatory role of synbiotics as antioxidants and how they reduce ROS and thus impede the process of carcinogenesis are also discussed.

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Authors and Affiliations

  1. Department of Biochemistry, Faculty of Science, Ekiti State University, Ado-Ekiti, Nigeria

    Olorunfemi R. Molehin

  2. Department of Science Laboratory Technology (Biotechnology Option), Faculty of Science, Ekiti State University, Ado-Ekiti, Nigeria

    Adeniyi S. Ohunayo

  3. Bioinformatics and Molecular Biology Unit, Department of Biochemistry, Federal University of Technology Akure, Akure, Nigeria

    Aderonke E. Fakayode

Authors
  1. Olorunfemi R. Molehin
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  2. Adeniyi S. Ohunayo
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  3. Aderonke E. Fakayode
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Corresponding author

Correspondence to Olorunfemi R. Molehin .

Editor information

Editors and Affiliations

  1. Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University Madhya Pradesh, Gwalior, Madhya Pradesh, India

    Neeraj Mishra

  2. School of Pharmacy, Dr. Vishwanath Karad MIT World Peace University, Pune, Maharashtra, India

    Shvetank Bhatt

  3. Faculty of Science, School of Life Sciences, Centre for Inflammation, Centenary Institute and University of Technology Sydney, Sydney, NSW, Australia

    Keshav Raj Paudel

  4. Faculty of Science, School of Life Sciences, Centre for Inflammation, Centenary Institute and University of Technology Sydney, Sydney, NSW, Australia

    Philip M Hansbro

  5. Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW, Australia

    Kamal Dua

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© 2023 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

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Molehin, O.R., Ohunayo, A.S., Fakayode, A.E. (2023). Correlation Between Reactive Oxygen Species and Synbiotics for Effective Treatment of Cancer. In: Mishra, N., Bhatt, S., Paudel, K.R., M Hansbro, P., Dua, K. (eds) Synbiotics for the Management of Cancer. Springer, Singapore. https://doi.org/10.1007/978-981-19-7550-9_4

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