Overview
- Discusses the role of iron metabolism in normal brain development
- Reviews implications of iron deficiency in neurodevelopmental and neurodegenerative diseases
- Present iron chelators as potential therapeutics for neurodevelopmental disorders
Part of the book series: Nutritional Neurosciences (NN)
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Table of contents (13 chapters)
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Front Matter
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Iron, Brain Function and Behavior
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Front Matter
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Brain Disorders Related to Iron
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Front Matter
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Keywords
About this book
This book explores the molecular mechanisms of iron hemostasis in the brain and discusses the cognitive and behavioral implications of iron deficiency. It presents the effect of iron dysregulation on neurophysiological mechanisms. The book provides an overview of iron metabolism and homeostasis at the cellular level and its regulation at the mRNA translation level. It emphasizes the importance of iron for brain development in fetal and early life in preterm infants.
Further, it presents iron metabolism as a therapeutic target for novel pharmacological treatment against neurodevelopmental diseases and neurodegenerative disorders. It discusses the role of iron deficiency in sleep disorders and offers diagnosis and treatment of iron-related CNS diseases. Finally, it relates dysregulated expression of iron-related genes in brain tumors.
​​Editors and Affiliations
About the editors
Dr. Mohamed is a Psychiatrist Neuroscientist. He is leading a research team in Egypt for translational brain research focusing on neurodegenerative disorders, animal models, and clinical trials. His research interests are focused on understanding neurological disease. Dr. Mohamed got his Ph.D. from PSU, USA, and is currently working as an Assistant Professor in IIUM Medical School, Malaysia. He has published over 64 peer-reviewed research articles related to Neuroscience/Psychiatry. Moreover, He authored for Springer, Taylor and Francis, and Elsevier i.e., 6 books and many book chapters on nutritional neuroscience & Neurodegenerative Disorders.
Prof Kostrzewa is working as a Professor in the Department of Biomedical Sciences at James H. Quillen College of Medicine. His interests focus on highly selective neurotoxins as the tools to uncover the ontogeny of monoaminergic systems in the brain and study nerve regeneration. He is involved in studying the reactive elements of one neuronal phenotype subsequent to the destruction of an alternate neuronal phenotype. He is an Editor-in-Chief of the journal Neurotoxicity Research and Editor-in-Chief of the 2nd edition of the Handbook of Neurotoxicity.
Dr. Nicola Luigi Bragazzi got his MD in general medicine and surgery from Genoa University (Genoa, Italy) in 2011, his Ph.D. in biophysics from Marburg University (Marburg, Germany) in 2014, and his specialization in Public Health from Genoa University (Genoa, Italy) in 2017. He is a member of the Cochrane Association (Cochrane Reviewer) for the Cochrane Epilepsy Group. President Carlo Azeglio Ciampi awarded him Young Knight of the Italian Republic in 2005. Recently, in 2019, he has been nominated as one of the top five biomedical researchers worldwide aged less than 40 years in terms of several publications, articles in Q1 biomedical journals. He is currently working on infectious disease and vaccination modeling and extensive data mining in biomedicine at York University
Bibliographic Information
Book Title: Brain-Iron Cross Talk
Editors: Wael Mohamed, Nicola Luigi Brogazzi, Richard M. Kostrzewa
Series Title: Nutritional Neurosciences
DOI: https://doi.org/10.1007/978-981-19-7327-7
Publisher: Springer Singapore
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2023
Hardcover ISBN: 978-981-19-7326-0Published: 17 December 2022
Softcover ISBN: 978-981-19-7329-1Published: 17 December 2023
eBook ISBN: 978-981-19-7327-7Published: 16 December 2022
Series ISSN: 2730-6712
Series E-ISSN: 2730-6720
Edition Number: 1
Number of Pages: XX, 280
Number of Illustrations: 3 b/w illustrations, 7 illustrations in colour
Topics: Neurosciences