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Case 46. A 3-Year-Old Girl with Fever and Pancytopenia: Hemophagocytic Lymphohistiocytosis Associated with Epstein-Barr Virus Infection

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Further Reading

  • Henter, J. et al. HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. file:///Users/jameschen/Desktop/henter2007.pdf (2007).

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  • Castagnini LA, Leach CT. In Feigin and Cherry’s Textbook of Pediatric Infectious Diseases, 18th ED, Chapter 160 Epstein-Barr virus, P. 1450-1474

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  • Kogawa K, et al. Prognostic factors of Epstein–Barr virus-associated hemophagocytic lymphohistiocytosis in children: Report of the Japan Histiocytosis Study Group. Pediatr Blood Cancer 2014; 61: 1257–1262.

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  • Locatelli F, Jordan MB, Allen C, et al. Emapalumab in children with primary hemophagocytic lymphohistiocytosis. N Engl J Med 2020;382:1811-1822.

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  • Lee WI, Chen SH, Hung IJ, Yang CP, Jaing TH, Chen CJ, et al. Clinical aspects, immunologic assessment, and genetic analysis in Taiwanese children with hemophagocytic lymphohistiocytosis. Pediatr Infect Dis J 2009; 28: 30-34

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  • Chen CY, Huang KY, Shen JH, Tsao KC, Huang YC. A large-scale seroprevalence of Epstein-Barr virus in Taiwan. PLoS One. 2015;10:e0115836.

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  • Zhao Y, Lu D, Ma S, Li L, Zhu J, Zhou, et al. Risk factors of early death in adult patients with secondary hemophagocytic lymphohistiocytosis: a single-institution study of 171 Chinese patients. Hematology 2019; 24:606-612

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  • Xu XJ, Wang HS, Ju XL, Xiao PF, Xiao Y, Xue HM, et al. Clinical presentation and outcome of pediatric patients with hemophagocytic lymphohistiocytosis in China: a retrospective multicenter study. Pediatr Blood Cancer, 2017;64(4), https://doi.org/10.1002/pbc.26264

  • Chen TY, Hsu MH, Kuo HC, Sheen JM, Cheng MC, Lin YJ. Outcome analysis of pediatric hemophagocytic lymphohistiocytosis. J Formos Med Assoc 2021; 120:172-179

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  • Yu TY, Lu MY, Lin KH, Chang HH, Chou SW, Lin DT, et al. Outcomes and prognostic factors associated with 180-day mortality in Taiwanese pediatric patients with Hemophagocytic Lymphohistiocytosis. J Formos Med Assoc 2021;120:1061-8

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Authors and Affiliations

  1. Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan

    Chih-Jung Chen

  2. Molecular Infectious Diseases Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan

    Chih-Jung Chen

  3. Pediatrics, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan

    Yhu-Chering Huang

Authors
  1. Chih-Jung Chen
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  2. Yhu-Chering Huang
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Corresponding author

Correspondence to Chih-Jung Chen .

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Editors and Affiliations

  1. Pediatrics, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan

    Yhu-Chering Huang

  2. Pediatrics, National Taiwan University Children’s Hospital, National Taiwan University, Taipei, Taiwan

    Ping-Ing Lee

  3. Pediatrics, Taichung Veterans General Hospital, National Chung Hsing University, Taichung City, Taiwan

    Po-Yen Chen

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© 2023 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

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Chen, CJ., Huang, YC. (2023). Case 46. A 3-Year-Old Girl with Fever and Pancytopenia: Hemophagocytic Lymphohistiocytosis Associated with Epstein-Barr Virus Infection. In: Huang, YC., Lee, PI., Chen, PY. (eds) Paediatric Infectious Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-19-7276-8_46

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  • DOI: https://doi.org/10.1007/978-981-19-7276-8_46

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-19-7275-1

  • Online ISBN: 978-981-19-7276-8

  • eBook Packages: MedicineMedicine (R0)

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