Abstract
Digital Microfluidics is rapidly evolving to automate procedures in biochemistry and molecular biology laboratories. Digital microfluidic biochip (DMFB) is a lab-on-chip (LOC) systems platform. DMFB technology offers abundant spatial parallelism and is inherently programmable based on micro-droplet manipulation on a miniaturized chip. DMFBs have evolved as an alternative to conventional biochemical laboratories. Droplets are transported, dispensed, analyzed, stored, reacted, or mixed on a platform with the help of insulated electrodes. DMFBs work with discrete droplet manipulation rather than continuous liquid flow. Several adjacent cells form a module that will carry out the required functionalities such as mixing, dilution, and detection. Module placement is an important task, and in this work, we formulate and solve the placement problem in DMFBs using a simple heuristic method. Modules should be placed according to the schedule inputted with minimum deviation and use as little area as possible to facilitate fault-tolerance. Two popular bioassays, multiplexed in vitro diagnostics and Colorimetric protein assay, are used for experimental evaluation.
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Rajesh, K., Tipparaju, R., Pyne, S. (2023). A Heuristic Algorithm for Module Placement in Digital Microfluidic Biochips. In: Darji, A.D., Joshi, D., Joshi, A., Sheriff, R. (eds) Advances in VLSI and Embedded Systems. Lecture Notes in Electrical Engineering, vol 962. Springer, Singapore. https://doi.org/10.1007/978-981-19-6780-1_19
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DOI: https://doi.org/10.1007/978-981-19-6780-1_19
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