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Skeletal Muscle Oxygenation in Patients with Malignant Hematopoietic Disease

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Physical Therapy and Research in Patients with Cancer

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Abstract

The noninvasive near-infrared spectroscopy (NIRS) technique has enabled a way to measure oxidative metabolism in muscle during exercise. Therefore, the NIRS technique has been used in research and clinical fields around the world to investigate the dynamic changes of hemoglobin and myoglobin in the skeletal muscle.

Our study used the NIRS technique to investigate hemodynamics in the muscle of patients with hematological malignancy who had undergone allogeneic transplantation. We chose the measurements of the tibialis anterior muscle during an isometric contraction task that induced muscle fatigue. Muscle fatigue is a very useful sign in the clinical setting because it was induced in either a supine or sitting posture setting. This protocol made it possible to measure muscle oxidative metabolism at bedside in a sterile isolation room during treatment for hematopoietic transplantation. Fatigue is an important clinical sign for interpreting oxidative metabolism in the muscle and leads to inevitably reduced exercise capacity in patients with hematological malignancy. NIRS parameters may be a useful outcome to interpret the clinical symptoms.

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Authors and Affiliations

  1. Department of Rehabilitation, Hyogo Medical University Hospital, Nishinomiya, Japan

    Tatsushi Wakasugi

  2. Department of Rehabilitation Medicine, Hyogo Medical University, Nishinomiya, Japan

    Yuki Uchiyama

  3. Department of Physical Therapy, School of Health Sciences, Fukushima Medical University, Fukushima, Japan

    Shinichiro Morishita

Authors
  1. Tatsushi Wakasugi
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  2. Yuki Uchiyama
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  3. Shinichiro Morishita
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Correspondence to Tatsushi Wakasugi .

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Editors and Affiliations

  1. Department of Physical Therapy, School of Health Sciences, Fukushima Medical University, Fukushima, Fukushima, Japan

    Shinichiro Morishita

  2. Division of Rehabilitation Medicine, Kobe University Hospital, Kobe, Hyogo, Japan

    Junichiro Inoue

  3. Department of Physical Therapy, Faculty of Rehabilitation, Kansai Medical University, Hirakata, Osaka, Japan

    Jiro Nakano

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Wakasugi, T., Uchiyama, Y., Morishita, S. (2022). Skeletal Muscle Oxygenation in Patients with Malignant Hematopoietic Disease. In: Morishita, S., Inoue, J., Nakano, J. (eds) Physical Therapy and Research in Patients with Cancer. Springer, Singapore. https://doi.org/10.1007/978-981-19-6710-8_22

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