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Neurocognitive Underpinning of Neurological Disorders: Role of Default Mode Network

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Abstract

Over the past few decades, the brain’s default mode network (DMN), consisting of a constellation of brain regions active during rest, has been associated with many neurological disorders. However, this network has recently shown activation during high-order social cognitive tasks attributed to self-referential processing and theory of mind. Furthermore, in several disorders with deficits in social cognition, or disrupted physiology including autism spectrum disorder (ASD), Alzheimer’s, Parkinson’s, hormonal cancer, and strikingly aberrant patterns of brain activity have been observed in certain cortical regions overlapping the DMN. This suggests that DNM overlaps the social brain network extensively involved in social cognitive processes and is often compromised in brain disorders. Here, we explore how an altered DMN may be plausibly extended as an indicator of neurological disorders.

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Authors and Affiliations

  1. Amity Institute of Neuropsychology and Neurosciences (AINN), Amity University, Noida, India

    Karamjeet Kaur Sarna

  2. Psychophysiology Laboratory, Department of Humanities and Social Sciences, Indian Institute of Technology Bombay, Mumbai, India

    Karamjeet Kaur Sarna & Azizuddin Khan

  3. Faculty of Behavioural Sciences, SGT University, Gurugram, India

    Karamjeet Kaur Sarna & Waheeda Khan

  4. University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India

    Sumant Saini

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  1. Karamjeet Kaur Sarna
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  2. Azizuddin Khan
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  3. Waheeda Khan
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  4. Sumant Saini
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Correspondence to Azizuddin Khan .

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  1. Department of Pharmaceutical Sciences, Faculty of Health Sciences, SHUATS, Allahabad, Uttar Pradesh, India

    Mahfoozur Rahman

  2. Department of Pharmacology and Toxicology, College of Pharmacy, Umm al-Qura University, Mecca, Saudi Arabia

    Waleed H Almalki

  3. Department of Pharmaceutics & and Pharmaceutical Technology, College of Pharmacy, Taif University, Taif, Saudi Arabia

    Majed Alrobaian

  4. Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India

    Sarwar Beg

  5. Department of Pharmacology, College of Pharmacy, Jouf University, Sakakah, Saudi Arabia

    Khalid S Alharbi

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Sarna, K.K., Khan, A., Khan, W., Saini, S. (2022). Neurocognitive Underpinning of Neurological Disorders: Role of Default Mode Network. In: Rahman, M., H Almalki, W., Alrobaian, M., Beg, S., Alharbi, K.S. (eds) Hormone Related Cancer Mechanistic and Nanomedicines. Springer, Singapore. https://doi.org/10.1007/978-981-19-5558-7_14

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