Abstract
Anti-asthma agents range from bronchial smooth muscle relaxants, anti-inflammatory agents, leukotriene inhibitors, and monoclonal antibodies. Hence, a diverse set of models are needed to test anti-asthma efficacy. While in-vivo models can test the efficacy in the presence of all physiological factors at play, in-vitro models can measure the contraction of airway smooth muscles directly. Testing monoclonal antibodies present an additional challenge as cytokines from animals and humans have a genetically different make-up.
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Shah, N.J. (2022). Screening Methods for the Evaluation of Antiasthmatic Agents. In: Lakshmanan, M., Shewade, D.G., Raj, G.M. (eds) Introduction to Basics of Pharmacology and Toxicology. Springer, Singapore. https://doi.org/10.1007/978-981-19-5343-9_34
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DOI: https://doi.org/10.1007/978-981-19-5343-9_34
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