Abstract
Nausea and emesis are the components of a protective reflex that helps to get rid the gastrointestinal tract from toxic substances and prevents further ingestion. Various potent antiemetic drugs like 5-HT3 antagonist, D2 blockers, and H1 blockers are utilised in the treatment of chemotherapy and radiotherapy- induced nausea and vomiting, post-operative nausea and vomiting, and others. Though potent antiemetics are available, each has its own advantages and disadvantages. Hence, the search for effective antiemetic agent with good therapeutic effect and minimal side effect is in process. Experimental drugs with possible antiemetic activity with different mechanism of action are screened by using various isolated muscle preparations like guinea pig ileum, taenia caecum, colon; rat duodenum, colon, uterus; and rabbit ileum and jejunum. In vivo methods evaluate the antiemetic activity of test drug in emesis induced by chemicals, drugs, motion and by radiation. In this chapter, in vivo methods employed in the screening of antiemetic drugs are discussed in detail.
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Maharani, B. (2022). Screening Methods for the Evaluation of Antiemetics. In: Lakshmanan, M., Shewade, D.G., Raj, G.M. (eds) Introduction to Basics of Pharmacology and Toxicology. Springer, Singapore. https://doi.org/10.1007/978-981-19-5343-9_30
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DOI: https://doi.org/10.1007/978-981-19-5343-9_30
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