Abstract
Celiac disease (CeD) is an autoimmune enteropathy caused by an aberrant immune response to gluten in genetically susceptible individuals. Though the data are heterogeneous, there is growing evidence to support that alterations in the composition and functions of the intestinal microbiota as well as infectious exposures in early childhood are associated with CeD. However, the mechanisms by which microorganisms contribute to the development of CeD remain elusive and the causal association between microorganisms and CeD has not been established. This chapter summarizes the available evidence on the interrelation between microorganisms and CeD describing the role of microorganisms in specific pathways involved in the pathogenesis of disease. Understanding the role of microorganisms in the pathogenesis of CeD would help to develop and refine microbiota modulating tools such as probiotics, prebiotics, microbe-derived gluten degrading enzymes, and fecal microbiome transfer, that can be used as therapeutic agents in CeD.
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Singh, A., Kaur, H., Midha, V., Sood, A. (2022). Microorganisms in the Pathogenesis and Management of Celiac Disease (CeD). In: Dwivedi, M.K., Sankaranarayanan, A., Kemp, E.H., Shoenfeld, Y. (eds) Role of Microorganisms in Pathogenesis and Management of Autoimmune Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-19-4800-8_15
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