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Microorganisms in the Pathogenesis and Management of Crohn’s Disease (CD)

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Role of Microorganisms in Pathogenesis and Management of Autoimmune Diseases

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Abstract

Crohn’s disease (CD) is a chronic inflammatory bowel disease. It is considered to affect any part of gastrointestinal tract, but it majorly affects ileum and colon. Previous studies suggest that the etiology of CD is multifactorial including environmental, genetic, and infectious factors. Numerous studies report a dysbiosis of intestinal microbiota due to an imbalance between harmful and beneficial bacteria and viruses. Studies have revealed the role of intestinal gut microbiota in the progression of CD. Hence, probiotics are used for the treatment of CD which are responsible for exhibiting health-promoting properties such as modulation of immune responses, inhibition of pathogenic bacteria for reducing inflammation in Crohn’s disease. The aim of this chapter is to provide insights on the gut microbiota-mediated pathogenesis in CD patients. In addition, the chapter also summarizes studies revealing potential role of probiotics, prebiotics, and fecal microbiota transplantation (FMT) approach for the treatment of CD.

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Acknowledgments

We are thankful to Uka Tarsadia University, Maliba Campus, Tarsadi, Gujarat, India for providing the facilities needed for the preparation of this chapter.

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  1. Faculty of Science, C. G. Bhakta Institute of Biotechnology, Uka Tarsadia University, Surat, Gujarat, India

    Firdosh Shah & Mitesh Kumar Dwivedi

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  1. Firdosh Shah
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Editors and Affiliations

  1. C.G. Bhakta Institute of Biotechnology, Uka Tarsadia University, Surat, Gujarat, India

    Mitesh Kumar Dwivedi

  2. Department of Life Sciences, Sri Sathya Sai University for Human Excellence, Kalaburagi, Karnataka, India

    A. Sankaranarayanan

  3. Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK

    E. Helen Kemp

  4. Zabludowicz Center for Autoimmunity, Sheba Medical Center, Tel-Hashomer, Israel

    Yehuda Shoenfeld

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Shah, F., Dwivedi, M.K. (2022). Microorganisms in the Pathogenesis and Management of Crohn’s Disease (CD). In: Dwivedi, M.K., Sankaranarayanan, A., Kemp, E.H., Shoenfeld, Y. (eds) Role of Microorganisms in Pathogenesis and Management of Autoimmune Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-19-4800-8_13

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