Abstract
Since established guidelines for the treatment of gynecological cancers in the elderly are lacking, decisions regarding the treatment plan and policy are currently made in consultation with the patient and family based on the doctor’s experience, referring to data from non-elderly and healthy elderly patients. Recently, a new concept of individualized treatment for gynecological cancer in the elderly has started to be established. In the treatment of cancer in the elderly, patients who can receive the standard treatment applicable to healthy non-elderly patients are considered “fit,” while those who cannot receive such treatment are considered “unfit.” Judgment of suitability requires a comprehensive evaluation of not only individual differences and calendar age, but also physical and mental disabilities, social and economic problems, and medical policy decisions in the case of elderly patients. In particular, when cognitive functions are declining, confirmation of the patient’s intentions can represent an obstacle to determining a treatment plan. In such cases, a comprehensive evaluation of the elderly is used to achieve functional assessment. The purpose of this review was to clarify the current status of surgery and chemotherapy for elderly gynecological cancer patients and to discuss future issues.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Oberaigner W, Minicozzi P, Bielska-Lasota M, Allemani C, de Angelis R, Mangone L, Sant M, Eurocare Working Group. Survival for ovarian cancer in Europe: the across-country variation did not shrink in the past decade. Acta Oncol. 2012;51(4):441–53.
Yancik R, Ries LA. Cancer in older persons: an international issue in an aging world. Semin Oncol. 2004;31(2):128–36.
Sant M, Chirlaque Lopez MD, Agresti R, Sánchez Pérez MJ, Holleczek B, Bielska-Lasota M, Dimitrova N, Innos K, Katalinic A, Langseth H, Larrañaga N, Rossi S, Siesling S, Minicozzi P, EUROCARE-5 Working Group. Survival of women with cancers of breast and genital organs in Europe 1999–2007: results of the EUROCARE-5 study. Eur J Cancer. 2015;51(15):2191–205.
Tew WP, Muss HB, Kimmick GG, Von Gruenigen VE, Lichtman SM. Breast and ovarian cancer in the older woman. J Clin Oncol. 2014;32(24):2553–61. https://doi.org/10.1200/JCO.2014.55.3073.
Kluetz P, Chingos DT, Basch EM, et al. Patient-reported outcomes in cancer clinical trials: measuring symptomatic adverse events with the National Cancer Institute’s patient-reported outcomes version of the common terminology criteria for adverse events (PRO-CTCAE). Am Soc Clin Oncol Educ Book. 2016;35:67–73.
LeBlanc TW, Abernethy AP. Patient-reported outcomes in cancer care—hearing the patient voice at greater volume. Nat Rev Clin Oncol. 2017;14(12):763–72.
Hightower RD, Nguyen HN, Averette HE, Hoskins W, Harrison T, Steren A. National survey of ovarian carcinoma. IV: Patterns of care and related survival for older patients. Cancer. 1994;73(2):377–83.
Fairfield KM, Lucas FL, Earle CC, Small L, Trimble EL, Warren JL. Regional variation in cancer-directed surgery and mortality among women with epithelial ovarian cancer in the Medicare population. Cancer. 2010;116(20):4840–8.
Thrall MM, Goff BA, Symons RG, Flum DR, Gray HJ. Thirty-day mortality after primary cytoreductive surgery for advanced ovarian cancer in the elderly. Obstet Gynecol. 2011;118(3):537–47.
Moore KN, Reid MS, Fong DN, Myers TK, Landrum LM, Moxley KM, Walker JL, McMeekin DS, Mannel RS. Ovarian cancer in the octogenarian: does the paradigm of aggressive cytoreductive surgery and chemotherapy still apply? Gynecol Oncol. 2008;110(2):133–9.
Thrall MM, Gray HJ, Symons RG, Weiss NS, Flum DR, Goff BA. Neoadjuvant chemotherapy in the Medicare cohort with advanced ovarian cancer. Gynecol Oncol. 2011;123(3):461–6. https://doi.org/10.1016/j.ygyno.2011.08.030.
Wimberger P, Lehmann N, Kimmig R, Burges A, Meier W, Hoppenau B, du Bois A, AGO-OVAR. Impact of age on outcome in patients with advanced ovarian cancer treated within a prospectively randomized phase III study of the Arbeitsgemeinschaft Gynaekologische Onkologie Ovarian Cancer Study Group (AGO-OVAR). Gynecol Oncol. 2006;100(2):300–7.
Langstraat C, Aletti GD, Cliby WA. Morbidity, mortality and overall survival in elderly women undergoing primary surgical debulking for ovarian cancer: a delicate balance requiring individualization. Gynecol Oncol. 2011;123(2):187–91.
Hershman D, Jacobson JS, McBride R, Mitra N, Sundararajan V, Grann VR, Neugut AI. Effectiveness of platinum-based chemotherapy among elderly patients with advanced ovarian cancer. Gynecol Oncol. 2004;94(2):540–9. https://doi.org/10.1016/j.ygyno.2004.04.022.
Lin JJ, Egorova N, Franco R, Prasad-Hayes M, Bickell NA. Ovarian cancer treatment and survival trends among women older than 65 years of Age in the United States, 1995–2008. Obstet Gynecol. 2016;127(1):81–9. https://doi.org/10.1097/AOG.0000000000001196.
Fairfield KM, Murray K, Lucas FL, Wierman HR, Earle CC, Trimble EL, Small L, Warren JL. Completion of adjuvant chemotherapy and use of health services for older women with epithelial ovarian cancer. J Clin Oncol. 2011;29(29):3921–6.
ESMO. Handbook of cancer in the senior patient. New York: Informa; 2010.
Wildider H. International Society of Geriatric Oncology consensus on geriatric assessment in older patients with cancer. J Clin Oncol. 2014;32:2595–603.
Ellis G, Whitehead MA, O’Neill D, et al. Comprehensive geriatric assessment for older adults admitted to hospital. Cochrane Database Syst Rev. 2011;7:CD006211.
Robinson TN, Wu DS, Pointer L, et al. Simple frailty score predicts postoperative complications across surgical specialties. Am J Surg. 2013;206:544–50.
Clough-Gorr KM, Stuck AE, Thwin SS, et al. Older breast cancer survivors: geriatric assessment domains are associated with poor tolerance of treatment adverse effects and predict mortality over 7 years of follow-up. J Clin Oncol. 2010;28:380–6.
Giannotti C, Sambuceti S, Signori A, et al. Frailty assessment in elective gastrointestinal oncogeriatric surgery: predictors of one-year mortality and functional status. J Geriatr Oncol. 2019;10:716–23.
Dale W, Hemmerich J, Kamm A, et al. Geriatric assessment improves prediction of surgical outcomes in older adults undergoing pancreaticoduodenectomy: a prospective cohort study. Ann Surg. 2014;259:960–5.
PACE Participants, Audisio RA, Pope D, Ramesh HS, et al. Shall we operate? Preoperative assessment in elderly cancer patients (PACE) can help. A SIOG surgical task force prospective study. Crit Rev Oncol Hematol. 2008;65:156–63.
Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(M146–56):6.
Balducci L, Stanta G. Cancer in the frail patient. A coming epidemic. Hematol Oncol Clin North Am. 2000;14:235–50.
Saliba S, Elliott M, Rubenstein LA, et al. The Vulnerable Elders Survey (VES-13): a tool for identifying vulnerable elders in the community. JAGS. 2001;49:1691–9.
Meldon SW, Mion LC, Palmer RM, et al. A brief risk-stratification tool to predict repeatemergency department visits and hospitalizations in older patients discharged from the emergency department. Acad Emerg Med. 2003;10:224–32.
Soubeyran P, Bellera C, Goyard J, et al. Validation of the G8 screening tool in geriatric oncology: the ONCODAGE project. J Clin Oncol. 2011;29(suppl; abstr 9001;2011 ASCO Annual Meeting).
Slaets JP. Vulnerability in the elderly: frailty. Med Clin North Am. 2006;90:593–601.
Overcash JA, Beckstead J, Moody L, et al. The abbreviated comprehensive geriatric assessment (aCGA) foruse in the older cancer patient as a prescreen: scoring andinterpretation. Crit Rev Oncol Hematol. 2006;59:205–10.
Rockwood K, Stadnyk K, MacKnight C, McDowell I, Hebert DBR. A brief clinical instrument to classify frailty in elderlypeople. Lancet. 1999;353:205–6.
Decoster L, Van Puyvelde K, Mohile S, et al. Screening tools for multidimensional health problems warranting a geriatric assessment in older cancer patients: an update on SIOG recommendations. Ann Oncol. 2015;26:288–300.
Puts MT, Hardt J, Monette J, Girre V, Springall E, Alibhai SM, et al. Use of geriatric assessment for older adults in theoncology setting: a systematic review. JNCI J Natl Cancer Inst. 2012;104:1134–64.
Kenis C, Bron D, Libert Y, et al. Relevance of a systematic geriatric screening and assessment in older patients with cancer: results of a prospective multicentric study. Ann Oncol. 2013;24:1306–12.
Hamaker ME, Jonker JM, de Rooij SE, et al. Frailty screening methods for predicting outcome of a comprehensive geriatric assessment in elderly patients with cancer: a systematic review. Lancet Oncol. 2012;13:37–44.
Owusu C, Koroukian SM, Schluchter M, et al. Screening older cancer patients for a Comprehensive Geriatric Assessment: a comparison of three instruments. J Geriatr Oncol. 2011;2:121–9.
Extermann M, Aapro M, Bernabei R, et al. Use of comprehensive geriatric assessmentin older cancer patients: recommendations from the task forceon CGA of the International Society of Geriatric Oncology (SIOG). Crit Rev Oncol Hematol. 2005;55:241–52.
Liuu E, Canouï-Poitrine F, Tournigand C, Laurent M, Caillet P, Le Thuaut A, Vincent H, Culine S, Audureau E, Bastuji-Garin S, Paillaud E, ELCAPA Study Group. Accuracy of the G-8 geriatric-oncology screening tool for identifying vulnerable elderly patients with cancer according to tumour site: the ELCAPA-02 study. J Geriatr Oncol. 2014;5(1):11–9. https://doi.org/10.1016/j.jgo.2013.08.003.
Ahmed A, Deng W, Tew W, Bender D, Mannel RS, Littell RD, DeNittis AS, Edelson M, Morgan M, Carlson J, Darus CJ, Fleury AC, Modesitt S, Olawaiye A, Evans A, Fleming GF. Pre-operative assessment and post-operative outcomes of elderly women with gynecologic cancers, primary analysis of NRG CC-002: an NRG oncology group/gynecologic oncology group study. Gynecol Oncol. 2018;150(2):300–5.
Extermann M, et al. Predicting the risk of chemotherapy toxicity in older patients: the Chemotherapy Risk Assessment Scale for High-Age Patients (CRASH) score. Cancer. 2012;118:3377–86.
Hurria A, Togawa K, Mohile SG, et al. Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study. J Clin Oncol. 2011;29:3457–65.
Mohile SG, Dale W, Somerfield MR, Hurria A. Practical assessment and management of vulnerabilities in older patients receiving chemotherapy: ASCO guideline for geriatric oncology summary. J Oncol Pract. 2018;14(7):442–6. https://doi.org/10.1200/JOP.18.00180.
Falandry C, Weber B, Savoye AM, Tinquaut F, Tredan O, Sevin E, Stefani L, Savinelli F, Atlassi M, Salvat J, Pujade-Lauraine E, Freyer G. Development of a geriatric vulnerability score in elderly patients with advanced ovarian cancer treated with first-line carboplatin: a GINECO prospective trial. Ann Oncol. 2013;24(11):2808–13.
Falandry C, Rousseau F, Mouret-Reynier MA, Tinquaut F, Lorusso D, Herrstedt J, Savoye AM, Stefani L, Bourbouloux E, Sverdlin R, D’Hondt V, Lortholary A, Brachet PE, Zannetti A, Malaurie E, Venat-Bouvet L, Trédan O, Mourey L, Pujade-Lauraine E, Freyer G, Groupe d’Investigateurs Nationaux pour l’Étude des Cancers de l’Ovaire et du sein (GINECO). Efficacy and safety of first-line single-agent carboplatin vs carboplatin plus paclitaxel for vulnerable older adult women with ovarian cancer: a GINECO/GCIG randomized clinical trial. JAMA Oncol. 2021;7(6):853–61. https://doi.org/10.1001/jamaoncol.2021.0696.
Ferrero A, Villa M, Tripodi E, Fuso L, Menato G. Can Vulnerable Elders Survey-13 predict the impact of frailty on chemotherapy in elderly patients with gynaecological malignancies? Medicine (Baltimore). 2018;97(39):e12298. https://doi.org/10.1097/MD.0000000000012298.
Acknowledgments
None
Disclosure
None of the authors have any conflicts of interest to declare in relation to this chapter.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2022 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Yoshida, Y., Inoue, D. (2022). Personalized Treatment of Gynecological Cancer According to Age and Symptom Benefit. In: Mandai, M. (eds) Personalization in Gynecologic Oncology. Comprehensive Gynecology and Obstetrics. Springer, Singapore. https://doi.org/10.1007/978-981-19-4711-7_9
Download citation
DOI: https://doi.org/10.1007/978-981-19-4711-7_9
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-19-4710-0
Online ISBN: 978-981-19-4711-7
eBook Packages: MedicineMedicine (R0)