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Gut Microbiota Impacts on the Efficacy of Anticancer Treatment of Colorectal Cancer

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Microbiome in Gastrointestinal Cancer

Abstract

Considering the stubbornly high morbidity and mortality and unsatisfactory clinical treatment efficacy of colorectal cancer (CRC), it is still urgent for exploring better therapy regimens. Various evidence have proved the important roles of gut microbiota in the development and treatment of CRC. Hence, the modulation of gut microbiota may be used as potential therapeutic approaches or adjuvants combined with other conventional treatments to prevent or treat CRC. Here, we summarize the diverse impacts of gut microbiota on different CRC therapeutic methods and discuss the potential clinical benefits of bacterial modulation with the goal of facilitating future research on the roles of the intestinal flora.

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  1. State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

    Jie Hong & Jing-Yuan Fang

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  1. Jie Hong
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Correspondence to Jing-Yuan Fang .

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  1. Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, China

    Jun Yu

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Hong, J., Fang, JY. (2023). Gut Microbiota Impacts on the Efficacy of Anticancer Treatment of Colorectal Cancer. In: Yu, J. (eds) Microbiome in Gastrointestinal Cancer. Springer, Singapore. https://doi.org/10.1007/978-981-19-4492-5_15

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