Skip to main content

Optimization in Fluid Mixing in Microchannels: A Review

  • Conference paper
  • First Online:
Recent Advances in Thermofluids and Manufacturing Engineering

Abstract

Optimization in improvement of mixing fluid in microchannel is reported in this paper. Number of articles have been reviewed regarding the mixing process of two miscible fluids. Mixing efficiency depends on the Reynolds number, velocities of the mixing fluids as well as the position and shape of the obstacles present in the microchannel. In order to have better mixing quality, various types of microfluidic devices need to be integrated with microfluidic systems. Due to low Reynolds number, the fluid diffusivity is low and hence it is required to create chaotic advection in microchannel to improve the fluid mixing efficiency by using advanced technology which is reviewed in this paper.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

Symbols :

Description

Re :

Reynolds number

θ c :

Circulation time

V :

Volume flow rate

Q :

Pumping capacity

P :

Power consumption

N :

Speed of impeller

D :

Diameter of impeller

Nmin :

Minimum agitation speed

t :

Time

ρ :

Density

∆ρ :

Density difference between continuous and dispersed phase, kg/m3

μ c :

Continuous phase viscosity, N s/m2

μ d :

Dispersed phase viscosity, N s/m2

σ :

Interfacial tension, Nm1

C 0 , a 0 :

Constants depend on impeller types and their locations

U :

Fluid flow velocity

L :

Length of the plate

ν :

Viscosity

References

  1. Muskett MJ (1986) The measurement of fluid mixing processes. Mater Des 7(4):188–191. https://doi.org/10.1016/0261-3069(86)90120-2

    Article  Google Scholar 

  2. Grenville RK, Nienow AW (2004) Blending of miscible liquids. Handb Ind Mixing, pp 507–542. https://doi.org/10.1002/0471451452

  3. Ghotli RA, Raman AAA, Ibrahim S, Baroutian S (2013) Liquid-liquid mixing in stirred vessels: a review. Chem Eng Commun 200(5):595–627. https://doi.org/10.1080/00986445.2012.717313

    Article  Google Scholar 

  4. Convery N, Gadegaard N (2019) 30 years of microfluidics. Micro Nano Eng 2:76–91. https://doi.org/10.1016/j.mne.2019.01.003

    Article  Google Scholar 

  5. Asghar C, Hossein F, Aghayie H, Reza V (2015) Numerical simulation of time- dependent electro-osmotic micro-mixer for laboratory-on-a-chip applications. Res J Recent Sci 4(2):83–90

    Google Scholar 

  6. Seok G, Seok J, Beom CC, Sang K, Lee H (2014) Applications of micromixing technology. Analyst 135(3):460. https://doi.org/10.1039/b921430e

    Article  Google Scholar 

  7. Bayareh M, Ashani MN, Usefian A (2020) Active and passive micro-mixers: a comprehensive review. Chem Eng Process 147. https://doi.org/10.1016/j.cep.2019.107771

  8. Hejazian M, Nguyen NT (2017) A rapid magnetofluidic micro-mixer using diluted ferrofluid. Micromachines 8(2):37. https://doi.org/10.3390/mi8020037

    Article  Google Scholar 

  9. Ward K, Fan ZH (2015) Mixing in microfluidic devices and enhancement methods 25. https://doi.org/10.1088/09601317/25/9/094001

  10. Sprogies T, Köhler JM, Groß GA (2008) Evaluation of static micro-mixers for flow-through extraction by emulsification. Chem Eng J 135:199–202. https://doi.org/10.1016/j.cej.2007.07.032

    Article  Google Scholar 

  11. Lee HY, Voldman J (2007) Optimizing micro-mixer design for enhancing dielectrophoretic microconcentrator performance. Anal Chem 79(5):1833–1839. https://doi.org/10.1021/ac061647q

    Article  Google Scholar 

  12. Fang W, Yang J (2009) A novel microreactor with 3D rotating flow to boost fluid reaction and mixing of viscous fluids. Sens Actuators B 140(2):629–642. https://doi.org/10.1016/J.SNB.2009.05.007

    Article  MathSciNet  Google Scholar 

  13. Rao LT, Goel S, Dubey SK, Javed A (2019) Performance investigation of T-shaped micro-mixer with different obstacles. J Phy 1276. https://doi.org/10.1088/1742-6596/1276/1/012003

  14. Santana HS, Júnior JLS, Taranto OP (2015) Numerical simulations of biodiesel synthesis in microchannels with circular obstructions. Chem Eng Process 98:137–146. https://doi.org/10.1016/j.cep.2015.10.011

    Article  Google Scholar 

  15. Oualha K, Amar MB, Michau A, Kanaev A (2017) Observation of cavitation in exocentric T-mixer. Chem Eng J 321:146–150. https://doi.org/10.1016/j.cej.2017.03.111

    Article  Google Scholar 

  16. Narayanamurthy V, Jeroish ZE, Bhuvaneswari KS, Bayat P, Premkumar R, Samsuri F, Yusoff MM (2020) Advances in passively driven microfluidics and lab-on-chip devices, a comprehensive literature review and patent analysis. RCS Adv 10(20):11652–11680. https://doi.org/10.1039/d0ra00263a

    Article  Google Scholar 

  17. Wang C-T, Chen Y-M (2011) Flow mixing of double two-inlet Y-Type micro channel with optimal layout of obstacles. J Mech 27(02):N1–N4. https://doi.org/10.1017/jmech.2011.22

    Article  Google Scholar 

  18. Huanming X, Jiawei W, Zhiping W (2018) A comparative discussion of different designs of passive micro-mixers: specific sensitivities of mixing efficiency on Reynolds numbers and fluid properties. Microsyst Technol 24(2):1253–1263. https://doi.org/10.1007/s00542-017-3496-4

    Article  Google Scholar 

  19. Sudarsan AP, Ugaz VM (2005) Fluid mixing in planar spiral microchannels. Lab Chip 6(1):74–82. https://doi.org/10.1039/b511524h

    Article  Google Scholar 

  20. Chiu PH, Chang CC, Yang RJ (2013) Electro kinetic micromixing of charged and non- charged samples near nano–microchannel junction. Microfluid Nanofluid 14(5):839–844. https://doi.org/10.1007/s10404-012-1116-2

    Article  Google Scholar 

  21. Gambhire S, Patel N, Gambhire G, Kale S (2016) A review on different micro-mixers and its micromixing channel microchannel. Mater Sci, pp 409–413. https://doi.org/10.14741/Ijcet/22774106/spl.4.2016.83

  22. Raza W, Hossain S, Kim KY (2020) A review of passive micro-mixers with a comparative analysis. Micromachines 11(5). https://doi.org/10.3390/mi11050455

  23. Rudyak V, Minakov A (2014) Modeling and optimization of Y-type micro-mixers. Micromachines 5(4):886–912. https://doi.org/10.3390/mi5040886

    Article  Google Scholar 

  24. Alexias P, Giannakoglou KC (2020) Shape optimization of a two-fluid mixing device using continuous adjoint. Fluids 5(1). https://doi.org/10.3390/fluids5010011

  25. Li L, Cheng Z, Lange CF (2018) CFD-based optimization of fluid flow product aided by artificial intelligence and design space validation. Math Prob Eng https://doi.org/10.1155/2018/8465020

  26. Andreasen CS, Gersborg AR, Sigmund O (2009) Topology optimization of microfluidic mixers. Int J Numer Methods Fluids 61:498–513. https://doi.org/10.1002/fld.1964

    Article  MathSciNet  MATH  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Swagatika Acharya .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2023 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Acharya, S., Mishra, V.K., Patel, J.K. (2023). Optimization in Fluid Mixing in Microchannels: A Review. In: Revankar, S., Muduli, K., Sahu, D. (eds) Recent Advances in Thermofluids and Manufacturing Engineering. Lecture Notes in Mechanical Engineering. Springer, Singapore. https://doi.org/10.1007/978-981-19-4388-1_7

Download citation

  • DOI: https://doi.org/10.1007/978-981-19-4388-1_7

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-19-4387-4

  • Online ISBN: 978-981-19-4388-1

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics