Abstract
Despite the global advancement in availability of modern diagnostic tools and a variety of therapeutic modalities, many diseases have still been on the rise worldwide. Animal models serve as a valuable means in conducting preclinical research related to various human diseases including cancer. These models assist not only to understand the underlying genetic mechanism of a tumor but also the impact of several crucial genes that quite often gets mutated leading to deadly cancers. Scientists are striving for regulated and customized animal models which mimic the real cancers in human beings in their growth and development. For developing animal models of cancer, a variety of animals and personalized as well as precision medicine methods are being used to cater the demand of different patients. Of these animal models of cancer, several mice models have been used worldwide due to their uniqueness in mimicking human cancers. Here, we have discussed about the major benefits and constraints related with the use of such models.
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Sharma, G., Goyal, Y., Bhatia, S. (2023). Preclinical Animal Models of Cancer: Applications and Limitations. In: Pathak, S., Banerjee, A., Bisgin, A. (eds) Handbook of Animal Models and its Uses in Cancer Research. Springer, Singapore. https://doi.org/10.1007/978-981-19-3824-5_54
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