Abstract
Pulmonary tumor thrombotic microangiopathy is an example of non-thrombotic pulmonary embolism, where widespread intra-luminal necrotic tumor-thrombus is associated with fibro-cellular proliferation. This ongoing sub-acute process is usually seen in patients with mammary, gastric, or pulmonary cancers. The consequent pulmonary hypertension leads to clinical presentations of sub-acute respiratory failure, congestive heart failure, or even sudden death. We report a case caused by uterine choriocarcinoma. Besides the arterial involvement, this patient had no other metastatic disease in the lungs or at other extra-pulmonary sites.
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Godbole RH, Saggar R, Kamangar N. Pulmonary tumor thrombotic microangiopathy: a systematic review. Pulm Circ. 2019;9:2045894019851000.
Hayashi S, Abe Y, Tomita S, Nakanishi Y, Miwa S, Nakajima T, Nomoto K, Tsuneyama K, Fujimori T, Imura J. Primary non-gestational pure choriocarcinoma arising in the ovary: a case report and literature review. Oncol Lett. 2015;9(5):2109–11.
Irene M, Njoroge M, Inyangala D, Caroline M, Mariga D, Waweru W, Shahbal S, Mwika P, Kuria K, Osawa F, Lessan J. Pure non-gestational ovarian choriocarcinoma. J Pediatr Surg Case Rep. 2019;40:1–5.
Khakural P, Shrestha KR, Sapkota R, Shrestha UK. An unusual case of pulmonary embolism. J Surg Case Rep. 2015;2015(2):rjv006.
Price LC, Wells AU, Wort SJ. Pulmonary tumour thrombotic microangiopathy. Curr Opin Pulm Med. 2016;22:421–8.
Seckl MJ, Fisher RA, Salerno G, Rees H, Paradinas FJ, Foskett M, Newlands ES. Choriocarcinoma and partial hydatidiform moles. Lancet. 2000;356(9223):36–9.
Skride A, Sablinskis K, Klepetko W, Lang I. Choriocarcinoma mimicking chronic thromboembolic pulmonary hypertension. Eur Heart J. 2016;37:1480.
Stockton L, Green E, Kaur B, De Winton E. Non-gestational choriocarcinoma with widespread metastases presenting with type 1 respiratory failure in a 39-year-old female: case report and review of the literature. Case Rep Oncol. 2018;11(1):151–8.
Ufuk F, Kaya F, Sagatas E, Kupeli A. Non-thrombotic pulmonary embolism in emergency CT. Emerg Radiol. 2020;27:343–50.
Zhu Y, Yu M, Ma L, Xu H, Li FR. Choriocarcinoma-associated pulmonary thromboembolism and pulmonary hypertension: a case report. J Biomed Res. 2016;30:243–7.
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Vaideeswar, P., Agnihotri, M. (2022). Uterine Choriocarcinoma with Pulmonary Tumor Thrombotic Microangiopathy. In: Vaideeswar, P. (eds) Tropical Cardiovascular Pathology. Springer, Singapore. https://doi.org/10.1007/978-981-19-3720-0_70
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DOI: https://doi.org/10.1007/978-981-19-3720-0_70
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