Abstract
Atherosclerosis, primarily an intimal disease of the arteries of all sizes, is considered as a chronic inflammation that occurs in response to multifactorial endothelial injury. Endothelial dysfunction facilitates the adhesion of circulating monocytes with subsequent transmigration and intimal accumulation as foam cells. In the recent years, neutrophils have been shown to play an unobtrusive role in the initiation, build-up, and complications of the atherosclerotic plaque. This case presentation highlights the exclusive accumulation of neutrophils within the coronary and aortic atherosclerotic plaques in a setting of septicemia, promoting a “second wave” of macrophage migration and accumulation.
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Further Reading
Cochain C, Ait-Oufella H, Zernecke A. Neutrophils promote atherosclerotic plaque destabilization in a mouse model of endotoxinaemia. Cardiovasc Res. 2018;114:1573–4.
Döring Y, Drechsler M, Soehnlein O, Weber C. Neutrophils in atherosclerosis: from mice to man. Arterioscler Thromb Vasc Biol. 2015;35:288–95.
Franck G. Role of mechanical stress and neutrophils in the pathogenesis of plaque erosion. Atherosclerosis. 2021;318:60–9.
Hartwig H, Roig S, Daemen M, Lutgens E, Soehnlein O. Neutrophils in atherosclerosis: a brief overview. Hamostaseologie. 2015;35:121–7.
Klopf J, Brostjan C, Eilenberg W, Neumayer C. Neutrophil extracellular traps and their implications in cardiovascular and inflammatory disease. Int J Mol Sci. 2021;22:559.
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Vaideeswar, P. (2022). Atherosclerosis and Neutrophils. In: Vaideeswar, P. (eds) Tropical Cardiovascular Pathology. Springer, Singapore. https://doi.org/10.1007/978-981-19-3720-0_59
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DOI: https://doi.org/10.1007/978-981-19-3720-0_59
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