Abstract
Proso millet (Panicum miliaceum L.) is a climate-resilient, ancient, and gluten-free cereal. This allotetraploid crop is healthy for humans and the environment. Its use as human food is steadily increasing, especially for people with diabetes and celiac disease due to its exceptional nutritional properties and gluten-free starch. There is no comprehensive review on proso millet seed nutraceuticals quantity, quality, characteristics, genetics, genomics (omics), and genetic improvement strategies. This review article aims to summarize published research on these aspects of proso millet seed nutrients and nutraceuticals. There are lots of reports on proso millet seed nutrients (macro, micro, and secondary metabolites) and their health benefits. There are a significant number of resources of “omics” tools for proso millet overall genetic improvement. However, no or very little genetic and genomic information (e.g., genes and genetic control mechanisms) and biosynthesis of majority of the nutraceuticals of proso millet seed are available. It may take years to see the full potential of “omics” for proso millet nutraceutomics. Phytochemical analyses and omics technologies are getting more efficient, faster, and cheaper. With this new opportunity, it is essential that proso millet scientists around the world especially food technologists, plant breeders, and geneticists of both public and private sectors work collaboratively for the genetic improvement of proso millet for nutraceutical. This will stimulate industries to use more proso millet in food products for human health and nutritional security under global climate change.
References
Akharume F, Santra D, Adedeji A (2020) Physicochemical and functional properties of proso millet storage protein fractions. Food Hydrocoll 108:105497. https://doi.org/10.1016/j.foodhyd.2019.105497
Anderson RL, Bowman RA, Nielsen DC et al (1999) Alternative crop rotations for the central Great Plains. J Prod Agric 12:95–99. https://doi.org/10.2134/jpa1999.0095
Argos P, Pedersen K, Marks MD, Larkins BA (1982) A structural model for maize zein proteins. J Biol Chem 257:9984–9990. https://doi.org/10.1016/S0021-9258(18)33974-7
Asharani VT, Jayadeep A, Malleshi NG (2010) Natural antioxidants in edible flours of selected small millets. Int J Food Prop 13:41–50. https://doi.org/10.1080/10942910802163105
Baltensperger DD (2002) Progress with proso, pearl and other millets. In: Janick J, Whipkey A (eds) Trends in new crops and new uses. ASHS Press, Alexandria, VA, pp 100–103
Bangar SP, Ashogbon AO, Dhull SB et al (2021) Proso-millet starch: properties, functionality, and applications. Int J Biol Macromol 190:960–968. https://doi.org/10.1016/j.ijbiomac.2021.09.064
Bobkov S, Suvorova G (2012) Temperature stress in anther culture of proso millet (Panicum miliaceum L.). In: Yan C, Baili F (eds) Proceedings of the 1st international broomcorn millet symposium: advances in broomcorn millet research, pp 82–88
Boukail S, Macharia M, Miculan M et al (2021) Genome wide association study of agronomic and seed traits in a world collection of proso millet (Panicum miliaceum L.). BMC Plant Biol 21:330. https://doi.org/10.1186/s12870-021-03111-5
Ceasar A (2022) Genome-editing in millets: current knowledge and future perspectives. Mol Biol Rep 49:773–781. https://doi.org/10.1007/s11033-021-06975-w
Chandrasekara A, Shahidi F (2011) Inhibitory activities of soluble and bound millet seed phenolics on free radicals and reactive oxygen species. J Agric Food Chem 59:428–436. https://doi.org/10.1021/jf103896z
Cho Y-I, Chung J-W, Lee G-A et al (2010) Development and characterization of twenty-five new polymorphic microsatellite markers in proso millet (Panicum miliaceum L.). Genes Genom 32:267–273. https://doi.org/10.1007/s13258-010-0007-8
Das S, Khound R, Santra M, Santra D (2019) Beyond bird feed: proso millet for human health and environment. Agriculture 9:64. https://doi.org/10.3390/agriculture9030064
Demirbas A (2005) Glucan and mineral nutrient contents of cereals grown in Turkey. Food Chem 90:773–777. https://doi.org/10.1016/j.foodchem.2004.06.003
Dendy DAV (1995) Sorghum and Millets: Chemistry and Technology. AACC, St. Paul, Minnesota, 406 pp.
Francis N, Rajasekaran R, Krishnamoorthy I et al (2022) Gamma irradiation to induce beneficial mutants in proso millet (Panicum miliaceum L.): an underutilized food crop. Int J Radiat Biol 98:1277–1288. https://doi.org/10.1080/09553002.2022.2024292
Geervani P, Eggum BO (1989) Nutrient composition and protein quality of minor millets. Plant Foods Hum Nutr 39:201–208. https://doi.org/10.1007/BF01091900
Gomashe SS (2017) Proso millet, Panicum miliaceum (L.): genetic improvement and research needs. In: Patil JV (ed) Millets and sorghum. John Wiley & Sons, Ltd, Chichester, pp 150–169
Gulati P, Li A, Holding D et al (2017) Heating reduces proso millet protein digestibility via formation of hydrophobic aggregates. J Agric Food Chem 65:1952–1959. https://doi.org/10.1021/acs.jafc.6b05574
Gulati P, Jia S, Li A et al (2018) In vitro pepsin digestibility of cooked proso millet (Panicum miliaceum L.) and related species from around the world. J Agric Food Chem 66:7156–7164. https://doi.org/10.1021/acs.jafc.8b02315
Gustin JL, Settles AM (2015) Seed phenomics. In: Fritsche-Neto R, Borém A (eds) Phenomics. Springer International Publishing, Cham, pp 67–82
Habiyaremye C, Matanguihan JB, D’Alpoim Guedes J et al (2017) Proso millet (Panicum miliaceum L.) and its potential for cultivation in the Pacific Northwest, U.S.: a review. Front Plant Sci 7. https://doi.org/10.3389/fpls.2016.01961
Heyser JW, Nabors MW (1982) Regeneration of proso millet from embryogenic Calli derived from various plant Parts1. Crop Sci 22:1070–1074. https://doi.org/10.2135/cropsci1982.0011183X002200050043x
Hou S, Sun Z, Li Y et al (2017) Transcriptomic analysis, genic SSR development, and genetic diversity of proso millet (Panicum miliaceum; Poaceae). Appl Plant Sci 5:1600137. https://doi.org/10.3732/apps.1600137
Hunt HV, Badakshi F, Romanova O et al (2014) Reticulate evolution in Panicum (Poaceae): the origin of tetraploid broomcorn millet, P miliaceum. J Exp Bot 65:3165–3175. https://doi.org/10.1093/jxb/eru161
Irshad A, Guo H, Zhang S, Liu L (2020) TILLING in cereal crops for allele expansion and mutation detection by using modern sequencing technologies. Agronomy 10:405. https://doi.org/10.3390/agronomy10030405
Johnson M, Deshpande S, Vetriventhan M et al (2019) Genome-wide population structure analyses of three minor millets: Kodo millet, little millet, and proso millet. Plant Genome 12:190021. https://doi.org/10.3835/plantgenome2019.03.0021
Jones RW, Beckwith AC, Khoo U, Inglett GE (1970) Protein composition of proso millet. J Agric Food Chem 18:37–39. https://doi.org/10.1021/jf60167a003
Kalinová J (2007) Nutritionally important components of proso millet (Panicum miliaceum L.). FoodReview 1:91–100
Kalinova J, Moudry J (2006) Content and quality of protein in proso millet (Panicum miliaceum L.) varieties. Plant Foods Hum Nutr 61:43–47. https://doi.org/10.1007/s11130-006-0013-9
Kalra EK (2003) Nutraceutical-definition and introduction. AAPS PharmSci 5:27–28. https://doi.org/10.1208/ps050325
Khound R, Santra DK (2020) Omics for proso millet genetic improvement. Nucleus 63:241–247. https://doi.org/10.1007/s13237-020-00339-8
Khound R, Santra M, Baenziger PS, Santra DK (2013) Effect of cold-mediated pretreatment on microspore culture in winter and spring wheat. Am J Plant Sci 04:2259–2264. https://doi.org/10.4236/ajps.2013.411278
Khound R, Sun G, Mural RV et al (2022) SNP discovery in proso millet (Panicum miliaceum L.) using low-pass genome sequencing. Plant Direct 6(9):e447. https://doi.org/10.1002/pld3.447
Kim JK, Park S-Y, Yeo Y et al (2013) Metabolic profiling of millet (Panicum miliaceum) using gas chromatography–time-of-flight mass spectrometry (GC-TOFMS) for quality assessment. Plant Omics J 6:73–78
Kumar GR, Sakthivel K, Sundaram RM et al (2010) Allele mining in crops: prospects and potentials. Biotechnol Adv 28:451–461. https://doi.org/10.1016/j.biotechadv.2010.02.007
Kumar A, Metwal M, Kaur S et al (2016) Nutraceutical value of finger millet [Eleusine coracana (L.) Gaertn.], and their improvement using omics approaches. Front Plant Sci 7:934. https://doi.org/10.3389/fpls.2016.00934
Kumari SK, Thayumanavan B (1998) Characterization of starches of proso, foxtail, barnyard, kodo, and little millets. Plant Foods Hum Nutr 53:47–56
Ladabaum U, Mannalithara A, Myer PA et al (2014) Obesity, abdominal obesity, physical activity, and caloric intake in US adults: 1988 to 2010. Am J Med 127(8):717–727.
Li C, Liu M, Sun F et al (2021) Genetic divergence and population structure in weedy and cultivated broomcorn millets (Panicum miliaceum L.) revealed by specific-locus amplified fragment sequencing (SLAF-Seq). Front Plant Sci 12:688444. https://doi.org/10.3389/fpls.2021.688444
Liang Z, Zhang K, Chen K, Gao C (2014) Targeted mutagenesis in Zea mays using TALENs and the CRISPR/Cas system. JGG 41:63–68.
Liang K, Liang S, Lu L et al (2018a) Metabolic variation and cooking qualities of millet cultivars grown both organically and conventionally. Food Res Int 106:825–833. https://doi.org/10.1016/j.foodres.2018.01.023
Liang Z, Gupta SK, Yeh C-T et al (2018b) Phenotypic data from inbred parents can improve genomic prediction in pearl millet hybrids. G3 (Bethesda) 8:2513–2522. https://doi.org/10.1534/g3.118.200242
Liu M, Xu Y, He J et al (2016) Genetic diversity and population structure of broomcorn millet (Panicum miliaceum L.) cultivars and landraces in China based on microsatellite markers. Int J Mol Sci 17:370. https://doi.org/10.3390/ijms17030370
Lorenz K (1983) Tannins and phytate content in proso millets (Panicum miliaceum). Cereal Chem 60:424–426
Lu H, Zhang J, Liu K et al (2009) Earliest domestication of common millet (Panicum miliaceum) in East Asia extended to 10,000 years ago. Proc Natl Acad Sci U S A 106:7367–7372. https://doi.org/10.1073/pnas.0900158106
Majid A, Priyadarshini CGP (2020) Millet derived bioactive peptides: a review on their functional properties and health benefits. Crit Rev Food Sci Nutr 60:3342–3351. https://doi.org/10.1080/10408398.2019.1686342
Malik S (2015) Pearl millet-nutritional value and medicinal uses. IJARIIE 1(3):414–418
Matsushima N, Danno G, Takezawa H, Izumi Y (1997) Three-dimensional structure of maize a-zein proteins studied by small-angle X-ray scattering. Biochim Biophys Acta 1339:14–22
Nielsen DC, Calderón FJ (2011) Fallow effects on soil. In: Hatfield JL, Sauer TJ (eds) Soil management: building a stable base for agriculture. Soil Science Society of America, Madison, pp 287–300
Parameswaran KP, Thayumanavan B (1995) Homologies between prolamins of different minor millets. Plant Foods Hum Nutr 48:119–126. https://doi.org/10.1007/BF01088307
Rajput SG, Santra DK, Schnable J (2016) Mapping QTLs for morpho-agronomic traits in proso millet (Panicum miliaceum L.). Mol Breed 36:37. https://doi.org/10.1007/s11032-016-0460-4
Rao BD, Bhaskarachary K, Arlene Christina GD et al (2017) Nutritional and health benefits of millets, 1st edn. ICAR- Indian Institute of Millets Research, Hyderabad
Ravindran G (1992) Seed protein of millets: amino acid composition, proteinase inhibitors and in-vitro protein digestibility. Food Chem 44:13–17. https://doi.org/10.1016/0308-8146(92)90251-V
Rose DJ, Santra DK (2013) Proso millet (Panicum miliaceum L.) fermentation for fuel ethanol production. Ind Crop Prod 43:602–605. https://doi.org/10.1016/j.indcrop.2012.08.010
Roy SK, Kwon S-J, Yu J-H et al (2017) Comparison of protein profiles of proso millet (Panicum miliaceum) seeds of various Korean cultivars. Korean J Crop Sci 62:40–50. https://doi.org/10.7740/KJCS.2016.62.1.040
Saleh ASM, Zhang Q, Chen J, Shen Q (2013) Millet grains: nutritional quality, processing, and potential health benefits. Compr Rev Food Sci Food Saf 12:281–295. https://doi.org/10.1111/1541-4337.12012
Santra DK (2013) Proso millet varieties for Western Nebraska. University of Nebraska-Lincoln NebGuide, Scottsbluff, Nebraska
Santra DK, Rose DJ (2013) Alternative uses of proso millet. University of Nebraska-Lincoln Extension, p G2218
Santra DK, Heyduck RF, Baltensperger DD et al (2015) Registration of ‘plateau’ waxy (amylose-free) proso millet. J Plant Regist 9:41–43. https://doi.org/10.3198/jpr2013.11.0067crc
Santra DK, Khound R, Das S (2019) Proso millet (Panicum miliaceum L.) breeding: progress, challenges and opportunities. In: Al-Khayri JM, Jain SM, Johnson DV (eds) Advances in plant breeding strategies: cereals. Springer International Publishing, Cham, pp 223–257
Shevchenko A, Yang Y, Knaust A et al (2014) Proteomics identifies the composition and manufacturing recipe of the 2500-year old sourdough bread from Subeixi cemetery in China. J Proteome 105:363–371. https://doi.org/10.1016/j.jprot.2013.11.016
Shi J, Ma X, Zhang J et al (2019) Chromosome conformation capture resolved near complete genome assembly of broomcorn millet. Nat Commun 10:464. https://doi.org/10.1038/s41467-018-07876-6
Singh V, Moreau RA, Hicks KB (2003) Yield and phytosterol composition of oil extracted from grain sorghum and its wet-milled fractions. Cereal Chem 80:126–129. https://doi.org/10.1094/CCHEM.2003.80.2.126
Singh M, Adedeji A, Santra D (2018) Physico-chemical and functional properties of nine proso millet cultivars. Trans ASABE 61:1165–1174. https://doi.org/10.13031/trans.12553
Singode A, Balakrishna D, Bhat V et al (2018) Improving yield using EMS mutation in proso millet (Panicum miliaceum L). In: Santra DK, Johnson JJ (eds) The 3rd international broomcorn millet symposium. Fort Collins, Colorado, USA
Srivastava RK, Singh RB, Pujarula VL et al (2020) Genome-wide association studies and genomic selection in pearl millet: advances and prospects. Front Genet 10:1389. https://doi.org/10.3389/fgene.2019.01389
Tripathi MK, Mohapatra D, Jadam RS et al (2021) Nutritional composition of millets. In: Kumar A, Tripathi MK, Joshi D, Kumar V (eds) Millets and millet technology. Springer Singapore, Singapore, pp 101–119
Varshney RK, Shi C, Thudi M et al (2017) Pearl millet genome sequence provides a resource to improve agronomic traits in arid environments. Nat Biotechnol 35:969–976. https://doi.org/10.1038/nbt.3943
Vetriventhan M, Upadhyaya HD (2018) Diversity and trait-specific sources for productivity and nutritional traits in the global proso millet (Panicum miliaceum L.) germplasm collection. Crop J 6:451–463. https://doi.org/10.1016/j.cj.2018.04.002
Wang R, Wang H, Liu X et al (2018) Waxy allelic diversity in common millet (Panicum miliaceum L.) in China. Crop J 6:377–385.
Wietgrefe GW (1990) How to produce proso millet (a Farmer’s guide). Wietgrefe, Gary W., Pierre, South Dakota
Yabe S, Iwata H (2020) Genomics-assisted breeding in minor and pseudo-cereals. Breed Sci 70:19–31. https://doi.org/10.1270/jsbbs.19100
Yue H, Wang L, Liu H et al (2016) De novo assembly and characterization of the transcriptome of broomcorn millet (Panicum miliaceum L.) for gene discovery and marker development. Front Plant Sci 7:1083. https://doi.org/10.3389/fpls.2016.01083
Zhang Y, Gao X, Li J et al (2019) Comparative analysis of proso millet (Panicum miliaceum L.) leaf transcriptomes for insight into drought tolerance mechanisms. BMC Plant Biol 19:397. https://doi.org/10.1186/s12870-019-2001-x
Zhao B, Khound R, Ghimire D et al (2022) Heading percentage estimation in proso millet (Panicum miliaceum L.) using aerial imagery and deep learning. Plant Phenome J. https://doi.org/10.1002/ppj2.20049
Zou C, Li L, Miki D et al (2019) The genome of broomcorn millet. Nat Commun 10:436. https://doi.org/10.1038/s41467-019-08409-5
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Khound, R., Mathivanan, R.K., Santra, D.K. (2023). Proso Millet Nutraceutomics for Human Health and Nutritional Security. In: Kole, C. (eds) Compendium of Crop Genome Designing for Nutraceuticals. Springer, Singapore. https://doi.org/10.1007/978-981-19-3627-2_10-1
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