Abstract
Complex regional pain syndrome (CRPS) is a chronic pain condition caused by a variety of diseases. The pathophysiology of CRPS is uncertain, and the diagnosis depends on clinical criteria. Three-phase bone scintigraphy (TPBS) using 99mTc-diphosphonates is helpful in documenting the symptoms and signs of CRPS and in the differential diagnosis of extremity pain. The typical pattern of TPBS in patients with CRPS is diffusely increased blood flow, blood pool, and delayed periarticular bone uptake in the affected extremity. In this chapter, we introduce several cases to help understand the findings and clinical usefulness of TPBS in patients with CRPS.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Fournier RS, Holder LE. Reflex sympathetic dystrophy: diagnostic controversies. Semin Nucl Med. 1998;28:116–23.
Howard BA, Roy L, Kaye AD, Pyati S. Utility of radionuclide bone scintigraphy in complex regional pain syndrome. Curr Pain Headache Rep. 2018;22:7.
Shim H, Rose J, Halle S, Shekane P. Complex regional pain syndrome: a narrative review for the practising clinician. Br J Anaesth. 2019;123:e424–e33.
Intenzo CM, Kim SM, Capuzzi DM. The role of nuclear medicine in the evaluation of complex regional pain syndrome type I. Clin Nucl Med. 2005;30:400–7.
Lee GW, Weeks PM. The role of bone scintigraphy in diagnosing reflex sympathetic dystrophy. J Hand Surg Am. 1995;20:458–63.
Urits I, Shen AH, Jones MR, Viswanath O, Kaye AD. Complex regional pain syndrome, current concepts and treatment options. Curr Pain Headache Rep. 2018;22:10.
Demangeat JL, Constantinesco A, Brunot B, Foucher G, Farcot JM. Three-phase bone scanning in reflex sympathetic dystrophy of the hand. J Nucl Med. 1988;29:26–32.
Park SA, Yang CY, Kim CG, Shin YI, Oh GJ, Lee M. Patterns of three-phase bone scintigraphy according to the time course of complex regional pain syndrome type I after a stroke or traumatic brain injury. Clin Nucl Med. 2009;34:773–6.
Shin SH, Kim SJ. Bone scintigraphy in patients with pain. Korean J Pain. 2017;30:165–75.
Cheon M, Kang HJ, Do KH, Yang HS, Han EJ, Yoo J. Diagnostic performance of three-phase bone scintigraphy and digital infrared thermography imaging for chronic post-traumatic complex regional pain syndrome. Diagnostics (Basel). 2021;11:1459.
Goldsmith DP, Vivino FB, Eichenfield AH, Athreya BH, Heyman S. Nuclear imaging and clinical features of childhood reflex neurovascular dystrophy: comparison with adults. Arthritis Rheum. 1989;32:480–5.
Laxer RM, Allen RC, Malleson PN, Morrison RT, Petty RE. Technetium 99m-methylene diphosphonate bone scans in children with reflex neurovascular dystrophy. J Pediatr. 1985;106:437–40.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2022 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Yoon, JK., Park, SA., Cho, Y.S., Park, J.M., Cha, J.G. (2022). Complex Regional Pain Syndrome. In: Yang, SO., Oh, S.W., Choi, Y.Y., Ryu, JS. (eds) Atlas of Nuclear Medicine in Musculoskeletal System. Springer, Singapore. https://doi.org/10.1007/978-981-19-2677-8_9
Download citation
DOI: https://doi.org/10.1007/978-981-19-2677-8_9
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-19-2676-1
Online ISBN: 978-981-19-2677-8
eBook Packages: MedicineMedicine (R0)