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Highlights on Biological Activities of 1,3,4-Thiadiazole and Indazole Derivatives

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Tailored Functional Materials

Part of the book series: Springer Proceedings in Materials ((SPM,volume 15))

Abstract

The 1,3,4-thiadiazole nucleus is a ubiquitous and intrinsic ingredient of a wide diversity of naturally occurring molecules and therapeutic medicines, and this moiety is realized as one of the immensely valued heterocyclic nuclei. The thiadiazole core is found in a wide range of drugs, including analgesic, anti-inflammatory, antineoplastic, antiepileptic, anti-bacterial, antitubercular, and antiviral agents. Thiadiazole and its derivatives have established themselves as pharmacologically relevant scaffolds due to their broad and potent activity. In another, diversely substituted indazole derivatives have a wide range of functional groups and possess a wide range of biological activities; therefore, these molecules acquired immense consideration in the field of biological chemistry. In this study, an attempt was made to review the structural alterations on several thiadiazole molecules for varied pharmacological actions using latest research discoveries on this nucleus. The advancements in the biological potential of indazole-based compounds are also highlighted.

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Abbreviations

AIDS:

Acquired immune deficiency syndrome

DNA:

Deoxyribonucleic acid

DPP-4:

Dipeptidyl peptidase-4

GIP:

Gastric inhibitory polypeptide

GLP-1:

Glucagon-like peptide 1

HER2:

Human epidermal growth factor receptor 2

HIV:

Human immunodeficiency virus

OAT4:

Organic anion carrier 4

OGTT:

Oral glucose tolerance test

OLIG2:

Oligodendrocyte lineage transcription factor 2

PARP:

Poly (ADP-ribose) polymerase

RNA:

Ribonucleic acid

SAR:

Structure–activity relationship

TNFα:

Tumor necrosis factor α

URAT1:

Uric acid carrier 1

U.S. FDA:

United State Food and Drug Administration

XPO1:

Exportin 1

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Author information

Authors and Affiliations

  1. Department of Chemistry, National Institute of Technology Manipur, Langol, Imphal, Manipur, 795004, India

    Arup K. Kabi, Raghuram Gujjarappa, Anupam Roy, Abhishek Sahoo & Chandi C. Malakar

  2. Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Kolkata, Chunilal Bhawan, 168, Maniktala Main Road, Kolkata, 700054, India

    Aakriti Garg & Sreya Gupta

Authors
  1. Arup K. Kabi
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  2. Raghuram Gujjarappa
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  3. Aakriti Garg
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  4. Anupam Roy
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  5. Abhishek Sahoo
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  6. Sreya Gupta
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  7. Chandi C. Malakar
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Corresponding authors

Correspondence to Sreya Gupta or Chandi C. Malakar .

Editor information

Editors and Affiliations

  1. Pandit Deendayal Energy University, Gandhinagar, India

    Kalisadhan Mukherjee

  2. School of Engineering Science, Department of Separation Science, LUT University, Lahti, Finland

    Rama Kanta Layek

  3. RGIPT - Energy Institute Bengaluru (Centre of Rajiv Gandhi Institute of Petroleum Technology), Bengaluru, India

    Debasis De

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Kabi, A.K. et al. (2022). Highlights on Biological Activities of 1,3,4-Thiadiazole and Indazole Derivatives. In: Mukherjee, K., Layek, R.K., De, D. (eds) Tailored Functional Materials. Springer Proceedings in Materials, vol 15. Springer, Singapore. https://doi.org/10.1007/978-981-19-2572-6_7

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