Skip to main content
SpringerLink
Log in

Effect of Plant-Derived Immunomodulators on the Immune System

  • Chapter
  • First Online:
Nutraceuticals and Functional Foods in Immunomodulators

Abstract

To regulate several immunological changes in the prevention of diseases, immunomodulators are helpful compounds which are derived naturally from plants. Since ancient times, people are using these natural compounds for treatment of several diseases. Immunomodulators are capable to fight against invaders by producing antibodies and cytotoxicity and maintain homeostasis of the immune system. Recent research focusing on investigations of new developments in immunomodulators has increased. Hence, this book chapter starts with introduction to immunomodulators and naturally existing plant-derived compounds and types. It also discusses about quercetin and its derived compounds with physicochemical properties and bioavailability. Furthermore, it highlights the mechanism of action of quercetin on the immune system with future challenges.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  • Abbas AK, Lichtman AH, Pillai S (2012) Basic immunology: functions and disorders of the immune system. Elsevier Health Sciences, New York

    Google Scholar 

  • Ader P, Wessmann A, Wolffram S (2000) Bioavailability and metabolism of the flavonol quercetin in the pig. Free Radic Biol Med 28(7):1056–1067

    Article  CAS  Google Scholar 

  • Ahmad NS et al (2008) Pharmacological basis for use of Pistacia integerrima leaves in hyperuricemia and gout. J Ethnopharmacol 117(3):478–482

    Article  Google Scholar 

  • Baxter D (2007) Active and passive immunity, vaccine types, excipients and licensing. Occup Med 57(8):552–556

    Article  Google Scholar 

  • Begum AN, Terao J (2002) Protective effect of quercetin against cigarette tar extract-induced impairment of erythrocyte deformability. J Nutr Biochem 13(5):265–272

    Article  CAS  Google Scholar 

  • Boots AW, Haenen GRMM, Bast A (2008) Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol 585:325–337

    Article  CAS  Google Scholar 

  • Chabane MN, Ahmad AA, Peluso J, Muller CD, Ubeaud-Séquier G (2009) Quercetin and naringenin transport across human intestinal Caco-2 cells. J Pharm Pharmacol 61(11):1473–1483

    Article  CAS  Google Scholar 

  • Chirumbolo S (2010) The role of quercetin, flavonols and flavones in modulating inflammatory cell function. Inflamm Allergy Drug Targets 9(4):263–285

    Article  CAS  Google Scholar 

  • Guo Y et al (2013) Dietary fat increases quercetin bioavailability in overweight adults. Mol Nutr Food Res 00:1–10

    Google Scholar 

  • Harwood M et al (2007) A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem Toxicol 45:2179–2205

    Article  CAS  Google Scholar 

  • Istudor V (1998) Pharmacognosy, phytochemistry, phytotherapy. In: Glycosides and lipids, 1

    Google Scholar 

  • Jantan I, Ahmad W, Bukhari SNA (2015) Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials. Front Plant Sci 6(655):1–18

    Google Scholar 

  • Kandere-Grzybowska K et al (2006) Regulation of IL-1-induced selective IL-6 release from human mast cells and inhibition by quercetin. Br J Pharmacol 148:208–215

    Article  CAS  Google Scholar 

  • Kharkar PB et al (2017) Nanosystems for oral delivery of immunomodulators, nanostructures for oral medicine. Elsevier

    Google Scholar 

  • Kim DH, Kim SY, Park SY, Han MJ (1999) Metabolism of quercitrin by human intestinal bacteria and its relation to some biological activities. Biol Pharm Bull 22(7):749–751

    Article  CAS  Google Scholar 

  • Konrad M, Nieman D (2014) Evaluation of quercetin as a countermeasure to exercise-induced physiological stress. In: Antioxidants in sport nutrition

    Google Scholar 

  • Kumar D et al (2012) A review of immunomodulators in the Indian traditional health care system. J Microbiol Immunol Infect 45:165–184

    Article  CAS  Google Scholar 

  • Lakhanpal P, Rai DK (2007) Quercetin: a versatile flavonoid. Internet J Med Update 2(2):22–37

    Google Scholar 

  • Li Y, Yao J, Han C, Yang J, Chaudhry MT, Wang S, Liu H, Yin Y (2016) Quercetin, inflammation and immunity. Nutrients 8(3):167. https://doi.org/10.3390/nu8030167

    Article  CAS  Google Scholar 

  • Lim H, Hyun PK (2007) Inhibition of mammalian collagenase, matrix metalloproteinase-1, by naturally-occurring flavonoids. Planta Med 73:1267–1274

    Article  CAS  Google Scholar 

  • Mlcek J, Jurikova T, Skrovankova S, Sochor J (2016) Quercetin and its anti-allergic immune response. Molecules (Basel, Switzerland) 21(5):623. https://doi.org/10.3390/molecules21050623

    Article  CAS  Google Scholar 

  • Muthian G, Bright JJ (2004) Quercetin, a flavonoid phytoestrogen, ameliorates experimental allergic encephalomyelitis by blocking IL-12 signaling through JAK-STAT pathway in T lymphocyte. J Clin Immunol 24(5):542–552

    Article  CAS  Google Scholar 

  • Nair MPN et al (2002) The flavonoid, quercetin, differentially regulates Th-1 (IFNγ) and Th-2 (IL4) cytokine gene expression by normal peripheral blood mononuclear cells. Biochim Biophys Acta 1593:29–36

    Article  CAS  Google Scholar 

  • Penissi AB, Rudolph MI, Piezzi RS (2003) Role of mast cells in gastrointestinal mucosal defense. Biocell 27(2):163–172

    Article  CAS  Google Scholar 

  • Shukla S, Bajpai VK, Kim M (2012) Plants as potential sources of natural immunomodulators. Rev Environ Sci Biotechnol 13:17–33

    Article  Google Scholar 

  • Singh N, Tailang M, Mehta SC (2016) A review on herbal plants as immunomodulators. Int J Pharm Sci Res 7(9):3602–3610

    CAS  Google Scholar 

  • Smit E, Oberholzer HM, Pretorius E (2009) A review of immunomodulators with reference to Canova®. Homeopathy 98:169–176

    Article  CAS  Google Scholar 

  • Valentová K et al (2016) (Anti)mutagenic and immunomodulatory properties of quercetin glycosides. J Sci Food Agric 96:1492–1499

    Article  Google Scholar 

  • Vásquez-Garzón V et al (2009) Inhibition of reactive oxygen species and pre-neoplastic lesions by quercetin through an antioxidant defense mechanism. Free Radic Res 43(2):128–137

    Article  Google Scholar 

  • Walle T, Walle UK, Halushka PV (2001) Carbon dioxide is the major metabolite of quercetin in humans. J Nutr 131(10):2648–2652

    Article  CAS  Google Scholar 

  • Wen CC, Chen HM, Yang NS (2012) Developing phytocompounds from medicinal plants as immunomodulators. In: Advances in botanical research, 1st edn. Elsevier

    Google Scholar 

Download references

Competing Interest

The authors declare that there are no competing interests.

Author information

Authors and Affiliations

  1. Department of Biotechnology, GITAM School of Science, GITAM Deemed to be University, Visakhapatnam, Andhra Pradesh, India

    Divya Vani Koraganji, Addanki Mounika, Pureti Sushanth & Prameela Kandra

  2. Department of Biotechnology, GITAM School of Technology, GITAM Deemed to be University, Visakhapatnam, India

    Addanki Mounika, Pureti Sushanth & Prameela Kandra

Authors
  1. Divya Vani Koraganji
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Addanki Mounika
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Pureti Sushanth
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Prameela Kandra
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Prameela Kandra .

Editor information

Editors and Affiliations

  1. Department of Computer Application, Nehru Gram Bharati (Deemed to be University), Prayagraj, Uttar Pradesh, India

    Rajesh K. Kesharwani

  2. Faculty of B. Pharmacy, CSM Group of Institutions, Prayagraj, Uttar Pradesh, India

    Raj K. Keservani

  3. All India Council for Technical Education, New Delhi, India

    Anil K. Sharma

Rights and permissions

Reprints and permissions

Copyright information

© 2022 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Koraganji, D.V., Mounika, A., Sushanth, P., Kandra, P. (2022). Effect of Plant-Derived Immunomodulators on the Immune System. In: Kesharwani, R.K., Keservani, R.K., Sharma, A.K. (eds) Nutraceuticals and Functional Foods in Immunomodulators. Springer, Singapore. https://doi.org/10.1007/978-981-19-2507-8_4

Download citation

Publish with us

Policies and ethics

Search

Navigation