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Microorganisms in Pathogenesis and Management of Psoriasis Arthritis (PsA)

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Role of Microorganisms in Pathogenesis and Management of Autoimmune Diseases

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Abstract

Psoriatic arthritis is a chronic inflammatory disease with a destructive course that can lead to severe functional impairment. It is one of the common complications of psoriasis, with a growing prevalence, the underlying mechanisms being not yet fully elucidated. The intestinal microbiota is made up of all the microorganisms that colonize the intestinal mucosa, being characterized by a great diversity and individual variability and quantitative or qualitative variations in its composition leading to a wide range of pathologies. Research in recent years has shown that understanding how the human body and microbiota interact and tolerate reciprocally is the starting point in understanding the pathophysiology of many inflammatory diseases, including psoriatic arthritis. Moreover, it has been observed that in addition to commensal microorganisms, other pathogenic microorganisms, such as bacteria, fungi, and viruses, are also involved in its appearance and exacerbation. A complete understanding of these mechanisms will thus be the starting point in the personalized treatment of psoriatic arthritis and other inflammatory diseases.

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Authors and Affiliations

  1. Department of Dermatology, Elias University Hospital, Bucharest, Romania

    Dobrică Elena-Codruța, Banciu Laura Mădălina & Voiculescu Vlad Mihai

  2. University of Medicine and Pharmacy of Craiova, Craiova, Romania

    Dobrică Elena-Codruța & Găman Amelia Maria

  3. “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania

    Voiculescu Vlad Mihai

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  1. Dobrică Elena-Codruța
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  2. Banciu Laura Mădălina
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  3. Voiculescu Vlad Mihai
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  4. Găman Amelia Maria
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Editors and Affiliations

  1. C.G. Bhakta Institute of Biotechnology, Uka Tarsadia University, Surat, Gujarat, India

    Mitesh Kumar Dwivedi

  2. C.G. Bhakta Institute of Biotechnology, Uka Tarsadia University, Surat, Gujarat, India

    N. Amaresan

  3. Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK

    E. Helen Kemp

  4. Zabludowizc Center for Autoimmunity, Sheba Medical Center, Tel-Hashomer, Israel

    Yehuda Shoenfeld

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Elena-Codruța, D., Mădălina, B.L., Mihai, V.V., Maria, G.A. (2022). Microorganisms in Pathogenesis and Management of Psoriasis Arthritis (PsA). In: Dwivedi, M.K., Amaresan, N., Kemp, E.H., Shoenfeld, Y. (eds) Role of Microorganisms in Pathogenesis and Management of Autoimmune Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-19-1946-6_19

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