Abstract
Background Although there were other reviews in 2019 and 2020, this is the first review of research that summarizes clinical features of the children with COVID-19 mentioned in literature in 2021. This paper analyses the findings on COVID-19 infection in children in three countries. Objective The purpose of this paper is to review publications using chest CT scans and chest X-ray findings for children with COVID-19 in 2021. Materials and methods Studies on COVID-19 for articles presenting scan findings in children with COVID-19 have been included in this review. This review focused on articles including 0 < age and age < 18 years using descriptive statistics to identify patterns including duration and several symptoms of the disease, and their relationship with outcomes. Results 12 research articles (n = 6212 children) based on chest CT scans and chest X-ray have been examined. The main results of this review article are as follows: (i) Approximately 1728 (27.81%) of pediatric patients with COVID-19 had normal chest CT scans and chest X-ray images. (ii) The most frequently detected parenchymal lesion was ground glass opacity (GGO) and also bilateral lesions were the common signs of lung lesions. (iii) The lung CT scan findings in children with COVID‐19 were less severe than in adult patients.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
WHO Director-General’s Statement on IHR Emergency Committee on Novel Coronavirus (2019-nCoV). https://www.who.int/dg/speeches/detail/who-director-general-s-statement-on-ihr-emergency-committee-on-novel-coronavirus-(2019-ncov). Accessed 2021/05/01
Weekly epidemiological update on COVID-19—20 Jul 2021. https://www.who.int/publications/m/item/weekly-epidemiological-update-on-covid-19---20-july-2021. Accessed 2021/08/01
Borakati A, Perera A, Johnson J, Sood T (2020) Diagnostic accuracy of X-ray versus CT in COVID-19: a propensity-matched database study. BMJ Open 10(11)
Sun Z, Zhang N, Li Y, Xu X (2020) A systematic review of chest imaging findings in COVID-19. Quant Imaging Med Surg 10(5):1058
Bottari G, Stellacci G, Ferorelli D, Dell’Erba A, Aricò M, Benevento M, Palladino G, Solarino B (2021) Imaging appropriateness in pediatric radiology during COVID-19 pandemic: a retrospective comparison with no COVID-19 Period. Children 8(6):463
Bai HX, Hsieh B, Xiong Z, Halsey K, Choi JW, Tran TML, Pan I, Shi LB, Wang DC, Mei J, Jiang XL, Liao WH (2020) Performance of radiologists in differentiating COVID-19 from non-COVID-19 viral pneumonia at chest CT. Radiol 296(2):E46–E54
Riphagen S, Gomez X, Gonzalez-Martinez C, Wilkinson N, Theocharis P (2020) Hyperinflammatory shock in children during COVID-19 pandemic. The Lancet 395(10237):1607–1608
Cao Q, Chen YC, Chen CL, Chiu CH (2020) SARS-CoV-2 infection in children: transmission dynamics and clinical characteristics. J Formos Med Assoc 119(3):670
Jin XM, Xu X (2013) The society of pediatrics, Chinese Medical Association-an intensive training programme for developmental and behavioral pediatrics. Zhonghua er ke za zhi= Chin J Pediatr 51(11):879–880
Shi F, Wang J, Shi J, Wu Z, Wang Q, Tang Z, He K, Shi Y, Shen D (2020) Review of artificial intelligence techniques in imaging data acquisition, segmentation, and diagnosis for COVID-19. IEEE Rev Biomed Eng 14:4–15
Stokes EK, Zambrano LD, Anderson KN, Marder EP, Raz KM, Felix SEB, Tie Y, Fullerton KE (2020) Coronavirus disease 2019 case surveillance—United States, 22 Jan–30 May, 2020. Morb Mortal Wkly Rep 69(24):759
Williams N, Radia T, Harman K, Agrawal P, Cook J, Gupta A (2021) COVID-19 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children and adolescents: a systematic review of critically unwell children and the association with underlying comorbidities. Eur J Pediatr 180(3):689–697
U.S. Census Bureau. Quick Facts United States. https://www.census.gov/quickfacts/fact/table/US/AGE295219#AGE295219externalicon. Accessed 2021/07/01
Centers for Disease Control and Prevention. Demographic trends of COVID-19 cases and deaths in the US reported to CDC. https://www.cdc.gov/covid-data-tracker/index.html#demographics. Accessed 2021/08/01
Heald-Sargent T, Muller WJ, Zheng X, Rippe J, Patel AB, Kociolek LK (2020) Age-related differences in nasopharyngeal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) levels in patients with mild to moderate coronavirus disease 2019 (COVID-19). JAMA Pediatr 174(9):902–903
Yonker LM, Neilan AM, Bartsch Y, Patel AB, Regan J, Arya P, Gootkind E, Park G, Hardcastle M, John AS, Appleman L, Fasano A (2020) Pediatric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): clinical presentation, infectivity, and immune responses. J Pediatr 227:45–52
Laws RL, Chancey RJ, Rabold EM, Chu VT, Lewis NM, Fajans M, Reses HE, Duca LM, Dawson P, Conners EE, Gharpure R, Kirking HL (2021) Symptoms and transmission of SARS-CoV-2 among children—Utah and Wisconsin, March–May 2020. Pediatr 147(1)
Centers for Disease Control and Prevention. COVID-19 pandemic planning scenarios. https://www.cdc.gov/coronavirus/2019-ncov/hcp/planning-scenarios.html#table-2. Accessed 2021/08/05
Information for Pediatric Healthcare Providers. https://www.cdc.gov/coronavirus/2019-ncov/hcp/pediatric-hcp.html. Accessed 2021/08/05
Poline J, Gaschignard J, Leblanc C, Madhi F, Foucaud E, Nattes E, Faye A, Bonacorsi S, Mariani P, Varon E, Smati-Lafarge M, Ouldali N (2021) Systematic severe acute respiratory syndrome coronavirus 2 screening at hospital admission in children: a French prospective multicenter study. Clin Infect Dis 72(12):2215–2217
Bayramoglu Z, Canıpek E, Comert RG, Gasimli N, Kaba O, Yanartaş MS, Torun SH, Somer A, Erturk SM (2021) Imaging features of pediatric COVID-19 on chest radiography and chest CT: a retrospective, single-center study. Acad Radiol 28(1):18–27
Karbuz A, Akkoc G, Demirdag TB, Ciftdogan DY, Ozer A, Cakir D, Torun SH, Kepenekli E, Erat T, Dalgic N, Ilbay S, Kara A (2021) Epidemiological, clinical, and laboratory features of children with COVID-19 in Turkey. Front Pediatr 9
Berksoy E, Kanik A, Çiçek A, Bardak Ş, Elibol P, Demir G, Yilmaz N, Nalbant T, Gökalp G, Yilmaz Çiftdoğan D (2021) Clinical and laboratory characteristics of children with SARS‐CoV‐2 infection. Pediatr Pulmonol
Kalin S, Ciraci S, Cakir D, Oysu AS, Sozeri B, Demir F, Bukte Y (2021) Evaluation of radiological findings in pediatric patients with COVID-19 in Turkey. Northern Clin Istanbul 8(4):332
Ferrero P, Piazza I (2021) Cardio-thoracic imaging and COVID-19 in the pediatric population: a narrative review. World J Radiol 13(4):94
Deville JG, Song E, Ouellette CP (2021) COVID-19: clinical manifestations and diagnosis in children
Romberg EK, Menashe SJ, Kronman MP, Tang ER, Stanescu AL, Otto RK, Otjen JP (2021) Pediatric radiologic manifestations of COVID-19. Clin Imaging 75:165–170
Fenlon Iii EP, Chen S, Ruzal-Shapiro CB, Jaramillo D, Maddocks AB (2021) Extracardiac imaging findings in COVID-19-associated multisystem inflammatory syndrome in children. Pediatr Radiol 51(5):831–839
Blumfield E, Levin TL, Kurian J, Lee EY, Liszewski MC (2021) Imaging findings in multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease (COVID-19). Am J Roentgenol 216(2):507–517
Rostad BS, Shah JH, Rostad CA, Jaggi P, Richer EJ, Linam LE, Alazraki AL, Riedesel EL, Milla SS (2021) Chest radiograph features of multisystem inflammatory syndrome in children (MIS-C) compared to pediatric COVID-19. Pediatr Radiol 51(2):231–238
Nino G, Molto J, Aguilar H, Zember J, Sanchez‐Jacob R, Diez CT, Tabrizi PR, Mohammed B, Weinstock J, Xuchen X, Kahanowitch R, Linguraru MG (2021) Chest X‐ray lung imaging features in pediatric COVID‐19 and comparison with viral lower respiratory infections in young children. Pediatr Pulmonol
Irfan O, Muttalib F, Tang K, Jiang L, Lassi ZS, Bhutta Z (2021) Clinical characteristics, treatment and outcomes of paediatric COVID-19: a systematic review and meta-analysis. Arch Dis Child 106(5):440–448
Adeyinka A, Bailey K, Pierre L, Kondamudi N (2021) COVID 19 infection: pediatric perspectives. J Am Coll Emerg Phys Open 2(1):e12375
Shuja J, Alanazi E, Alasmary W, Alashaikh A (2021) COVID-19 open source data sets: a comprehensive survey. Appl Intell 51(3):1296–1325
Mamikutty R, Aly AS, Marhazlinda J (2021) Databases selection in a systematic review of the association between anthropometric measurements and dental caries among children in Asia. Child 8(7):565
Zang ST, Han X, Cui Q, Chang Q, Wu QJ, Zhao YH (2021) Imaging characteristics of coronavirus disease 2019 (COVID-19) in pediatric cases: a systematic review and meta-analysis. Transl Pediatr 10(1):1
Trout AT, Westra SJ (2021) Imaging in support of the clinical diagnoses of COVID-19 and multisystem inflammatory syndrome in children. Pediatr Radiol 51(5):693–694
Tulchin-Francis K, Stevens Jr W, Gu X, Zhang T, Roberts H, Keller J, Dempsey D, Borchard J, Jeans K, VanPelt J (2021) The impact of the coronavirus disease 2019 pandemic on physical activity in US children. J Sport Health Sci 10(3):323–332
Bayesheva D, Boranbayeva R, Turdalina B, Fakhradiyev I, Saliev T, Tanabayeva S, Zhussupov B, Nurgozhin T (2021) COVID-19 in the paediatric population of Kazakhstan. Paediatr Int Child Health 41(1):76–82
Savaş BK, Becerikli Y (2020) Real time driver fatigue detection system based on multi-task ConNN. IEEE Access 8(1):12491–12498
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
About this paper
Cite this paper
Savaş, B.K. (2023). A Review of a Research in 2021 on Coronavirus Disease (COVID-19) in Pediatric Patients. In: Yang, XS., Sherratt, S., Dey, N., Joshi, A. (eds) Proceedings of Seventh International Congress on Information and Communication Technology. Lecture Notes in Networks and Systems, vol 448. Springer, Singapore. https://doi.org/10.1007/978-981-19-1610-6_70
Download citation
DOI: https://doi.org/10.1007/978-981-19-1610-6_70
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-19-1609-0
Online ISBN: 978-981-19-1610-6
eBook Packages: EngineeringEngineering (R0)