Skip to main content

A Comprehensive Study of Explainable Artificial Intelligence in Healthcare

  • Chapter
  • First Online:
Augmented Intelligence in Healthcare: A Pragmatic and Integrated Analysis

Part of the book series: Studies in Computational Intelligence ((SCI,volume 1024))

Abstract

The recent development of Artificial intelligence and Machine learning, in general, has exhibited impressive results in a variety of fields, especially through the introduction of deep learning (DL). Even though they show an extraordinary performance in a substantial number of jobs and have tremendous potential. This surge in performance is usually pulled off through the increase in model complexity, giving rise to the black-box model and creating confusion about how they work and, ultimately, how they make judgments. This uncertainty has made it difficult for machine-learning programs to be used in more sensitive but essential areas, such as health care, where their benefits can be enormous, Thus giving birth to the need for Explainable AI. Explainable Artificial Intelligence (XAI) is a new machine-learning research subject aiming at decoding how AI systems make black-box decisions. This chapter focuses on the need for Explainable AI in the field of healthcare and some techniques like LIME, SHAP, PDPs, and a few others, through which complex models can be explained. We will see the use of explainable methods by analyzing two case studies. Through the use of this article, clinicians, theorists, and practitioners can get a better insight into how these models work and can help to bring a high level of accountability and transparency.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Kelly, C. J., Karthikesalingam, A., Suleyman, M., Corrado, G., & King, D. (2019). Key challenges for delivering clinical impact with artificial intelligence. BMC Medicine, 17(1), 1–9.

    Article  Google Scholar 

  2. Tripathy, H. K., Mallick, P. K., & Mishra, S. (2021). Application and evaluation of classification model to detect autistic spectrum disorders in children. International Journal of Computer Applications in Technology, 65(4), 368–377.

    Article  Google Scholar 

  3. Chen, L., Bentley, P., & Rueckert, D. (2017). Fully automatic acute ischemic lesion segmentation in DWI using convolutional neural networks. NeuroImage: Clinical, 15, 633–643.

    Google Scholar 

  4. Mishra, S., Dash, A., Ranjan, P., & Jena, A. K. (2021). Enhancing heart disorders prediction with attribute optimization. In Advances in Electronics, Communication and Computing (pp. 139–145). Springer Singapore.

    Google Scholar 

  5. Adadi, A., & Berrada, M. (2018). Peeking inside the black-box: A survey on explainable artificial intelligence (XAI). IEEE Access, 6, 52138–52160.

    Article  Google Scholar 

  6. Gunning, D., & Aha, D. (2019). DARPA’s explainable artificial intelligence (XAI) program. AI Magazine, 40(2), 44–58.

    Article  Google Scholar 

  7. Schwalbe, G., & Finzel, B. (2021). XAI method properties: A (meta-) study. arXiv preprint arXiv:2105.07190

  8. Dilsizian, S. E., & Siegel, E. L. (2014). Artificial intelligence in medicine and cardiac imaging: Harnessing big data and advanced computing to provide personalized medical diagnosis and treatment. Current Cardiology Reports, 16(1), 441.

    Article  Google Scholar 

  9. Patel, V. L., Shortliffe, E. H., Stefanelli, M., Szolovits, P., Berthold, M. R., Bellazzi, R., & Abu-Hanna, A. (2009). The coming of age of artificial intelligence in medicine. Artificial Intelligence in Medicine, 46(1), 5–17.

    Article  Google Scholar 

  10. Jha, S., & Topol, E. J. (2016). Adapting to artificial intelligence: Radiologists and pathologists as information specialists. JAMA, 316(22), 2353–2354.

    Article  Google Scholar 

  11. Strickland, E. (2019). IBM Watson, heal thyself: How IBM overpromised and underdelivered on AI health care. IEEE Spectrum, 56(4), 24–31.

    Article  MathSciNet  Google Scholar 

  12. Weingart, N. S., Wilson, R. M., Gibberd, R. W., & Harrison, B. (2000). Epidemiology of medical error. BMJ, 320(7237), 774–777.

    Article  Google Scholar 

  13. Ker, J., Wang, L., Rao, J., & Lim, T. (2017). Deep learning applications in medical image analysis. IEEE Access, 6, 9375–9389.

    Google Scholar 

  14. Yang, G., Ye, Q., & Xia, J. (2021). Unbox the black-box for the medical explainable AI via multi-modal and multi-centre data fusion: A mini-review, two showcases and beyond. arXiv preprint arXiv:2102.01998

  15. Miller, R. A. (1994). Medical diagnostic decision support systems—Past, present, and future: A threaded bibliography and brief commentary. Journal of the American Medical Informatics Association, 1(1), 8–27.

    Article  Google Scholar 

  16. Musen, M. A., Middleton, B., & Greenes, R. A. (2021). Clinical decision-support systems. In Biomedical informatics (pp. 795–840). Springer.

    Google Scholar 

  17. Kundu, M., Nasipuri, M., & Basu, D. K. (2000). Knowledge-based ECG interpretation: A critical review. Pattern Recognition, 33(3), 351–373.

    Article  Google Scholar 

  18. De Dombal, F. T., Leaper, D. J., Staniland, J. R., McCann, A. P., & Horrocks, J. C. (1972). Computer-aided diagnosis of acute abdominal pain. British Medical Journal, 2(5804), 9–13.

    Article  Google Scholar 

  19. Shortliffe, E. H., Davis, R., Axline, S. G., Buchanan, B. G., Green, C. C., & Cohen, S. N. (1975). Computer-based consultations in clinical therapeutics: Explanation and rule acquisition capabilities of the MYCIN system. Computers and Biomedical Research, 8(4), 303–320.

    Article  Google Scholar 

  20. Barnett, G. O., Cimino, J. J., Hupp, J. A., & Hoffer, E. P. (1987). DXplain: An evolving diagnostic decision-support system. JAMA, 258(1), 67–74.

    Article  Google Scholar 

  21. Miller, R. A., McNeil, M. A., Challinor, S. M., Masarie, F. E., Jr., & Myers, J. D. (1986). The INTERNIST-1/quick medical REFERENCE project—Status report. Western Journal of Medicine, 145(6), 816.

    Google Scholar 

  22. Yu, K. H., & Snyder, M. (2016). Omics profiling in precision oncology. Molecular & Cellular Proteomics, 15(8), 2525–2536.

    Article  Google Scholar 

  23. Deo, R. C. (2015). Machine learning in medicine. Circulation, 132(20), 1920–1930.

    Article  Google Scholar 

  24. Mishra, S., Mohapatra, S. K., Mishra, B. K., & Sahoo, S. (2018). Analysis of mobile cloud computing: Architecture, applications, challenges, and future perspectives. In Applications of security, mobile, analytic, and cloud (SMAC) technologies for effective information processing and management (pp. 81–104). IGI Global.

    Google Scholar 

  25. Yu, K. H., Beam, A. L., & Kohane, I. S. (2018). Artificial intelligence in healthcare. Nature Biomedical Engineering, 2(10), 719–731.

    Article  Google Scholar 

  26. Zeiler, M. D., & Fergus, R. (2014, September). Visualizing and understanding convolutional networks. In European Conference on Computer Vision (pp. 818–833). Springer.

    Google Scholar 

  27. Simonyan, K., Vedaldi, A., & Zisserman, A. (2014). Deep inside convolutional networks: Visualising image classification models and saliency maps. In Workshop at International Conference on Learning Representations.

    Google Scholar 

  28. Selvaraju, R. R., Cogswell, M., Das, A., Vedantam, R., Parikh, D., & Batra, D. (2017). Grad-CAM: Visual explanations from deep networks via gradient-based localization. In Proceedings of the IEEE International Conference on Computer Vision (pp. 618–626).

    Google Scholar 

  29. Zhang, Z., Xie, Y., Xing, F., McGough, M., & Yang, L. (2017). MDNet: A semantically and visually interpretable medical image diagnosis network. In Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition (pp. 6428–6436).

    Google Scholar 

  30. Quinn, T. P., Jacobs, S., Senadeera, M., Le, V., & Coghlan, S. (2021). The three ghosts of medical AI: Can the black-box present deliver? Artificial Intelligence in Medicine, 102158.

    Google Scholar 

  31. Mishra, S., Panda, A., & Tripathy, K. H. (2018). Implementation of re-sampling technique to handle skewed data in tumor prediction. Journal of Advanced Research in Dynamical and Control Systems, 10, 526–530.

    Google Scholar 

  32. Chen, H., Michalopoulos, G., Subendran, S., Yang, R., Quinn, R., Oliver, M., Butt, Z., & Wong, A. (2019). Interpretability of ML models for health data—A case study.

    Google Scholar 

  33. Modhukur, V., Sharma, S., Mondal, M., Lawarde, A., Kask, K., Sharma, R., & Salumets, A. (2021). Machine learning approaches to classify primary and metastatic cancers using tissue of origin-based DNA methylation profiles. Cancers, 13(15), 3768.

    Article  Google Scholar 

  34. Linardatos, P., Papastefanopoulos, V., & Kotsiantis, S. (2021). Explainable AI: A review of machine learning interpretability methods. Entropy, 23(1), 18.

    Article  Google Scholar 

  35. Magesh, P. R., Myloth, R. D., & Tom, R. J. (2020). An explainable machine learning model for early detection of Parkinson’s disease using LIME on DaTSCAN imagery. Computers in Biology and Medicine, 126, 104041.

    Google Scholar 

  36. Doppalapudi, S., Qiu, R. G., & Badr, Y. (2021). Lung cancer survival period prediction and understanding: Deep learning approaches. International Journal of Medical Informatics, 148, 104371.

    Google Scholar 

  37. Poewe, W., Seppi, K., Tanner, C. M., Halliday, G. M., Brundin, P., Volkmann, J., Schrag, A.-E., & Lang, A. E. (2017). Parkinson disease. Nature Reviews Disease Primers, 3(1).

    Google Scholar 

  38. Booth, T. C., Nathan, M., Waldman, A. D., Quigley, A. M., Schapira, A. H., & Buscombe, J. (2015). The role of functional dopamine-transporter SPECT imaging in Parkinsonian syndromes, part 1. American Journal of Neuroradiology, 36(2), 229–235.

    Article  Google Scholar 

  39. Tripathy, H. K., Mishra, S., Thakkar, H. K., & Rai, D. (2021). CARE: A collision-aware mobile robot navigation in grid environment using improved breadth first search. Computers & Electrical Engineering, 94, 107327.

    Google Scholar 

  40. Lundervold, A. S., & Lundervold, A. (2019). An overview of deep learning in medical imaging focusing on MRI. Zeitschrift für Medizinische Physik, 29(2), 102–127.

    Article  Google Scholar 

  41. Lundberg, S. M., & Lee, S. I. (2017, December). A unified approach to interpreting model predictions. In Proceedings of the 31st International Conference on Neural Information Processing Systems (pp. 4768–4777).

    Google Scholar 

  42. Friedman, J. H. (2001). Greedy function approximation: A gradient boosting machine. Annals of Statistics, 1189–1232.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Sushruta Mishra .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2022 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Mohanty, A., Mishra, S. (2022). A Comprehensive Study of Explainable Artificial Intelligence in Healthcare. In: Mishra, S., Tripathy, H.K., Mallick, P., Shaalan, K. (eds) Augmented Intelligence in Healthcare: A Pragmatic and Integrated Analysis. Studies in Computational Intelligence, vol 1024. Springer, Singapore. https://doi.org/10.1007/978-981-19-1076-0_25

Download citation

Publish with us

Policies and ethics