Abstract
Serum and plasma are widely used biological fluids for a large variety of biochemical and pathological tests which have been used since historical times for diagnosis and prophylactic analysis. High altitude physiology and related pathologies are geographically localized socio-economic issues of a large set of population. In the last few decades, considerable research has been done to explore the underlying proteomic changes in serum and plasma of humans as well as in the model organisms. Recent studies have led to the emergence of a number of potential prophylactic and therapeutic targets which enable better and timely diagnosis, effective therapy, and also susceptibility testing of high altitude related illness. As proteome is highly dynamic in time and space, and serum or plasma is known to reflect the proteomic changes in various organs. Although analysis of plasma or serum is an invasive approach, yet the specificity of plasma-based markers holds great promise in diagnostics. In this chapter, we will discuss general approaches to use plasma and serum proteome, followed by examples of potential biomarkers or indicators of hypobaric-hypoxia-induced perturbations.
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Arya, A., Kumar, A. (2022). Serum and Plasma Proteomics for High Altitude Related Biomarker Discovery. In: Sharma, N.K., Arya, A. (eds) High Altitude Sickness – Solutions from Genomics, Proteomics and Antioxidant Interventions. Springer, Singapore. https://doi.org/10.1007/978-981-19-1008-1_9
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DOI: https://doi.org/10.1007/978-981-19-1008-1_9
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