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High Altitude Related Diseases: Milder Effects, HACE, HAPE, and Effect on Various Organ Systems

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High Altitude Sickness – Solutions from Genomics, Proteomics and Antioxidant Interventions

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Abstract

Proteomics has emerged as an excellent biomarker discovery tool in recent years owing to the rapid emergence and growth of high throughput proteomics approaches and advancements in mass spectrometry methods especially in terms of mass analysers and resolution. Moreover, plasma and serum have always been a choice of diagnostic fluid since historical times and have always been a preferred diagnostic sample by clinicians. Although plasma is disproportionate in terms of composition as some proteins such as albumin and globulins are highly abundant, while others are found in traces. The emergence of methods to deplete the high abundance of proteins has led to a remarkable refinement in plasma or serum composition for its diagnostic abilities. Plasma proteins are always considered the gold standard for several metabolic changes induced by diseases or altered physiology. High altitude related physiological changes have also been evaluated recently over the proteomic scale and seemingly represent a potential source for exploring biomarkers for such physiological changes. This chapter describes the hypobaric hypoxia-induced changes in the plasma and serum proteome and potential biomarkers which have enormous commercial and clinical potential.

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Authors and Affiliations

  1. Department of Biotechnology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, India

    Sneha Singh & Mairaj Ahmed Ansari

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  1. Sneha Singh
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  2. Mairaj Ahmed Ansari
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Editors and Affiliations

  1. Department of Bioscience and Biotechnology, Banasthali Vidyapith, Tonk, Rajasthan, India

    Narendra Kumar Sharma

  2. National Institute of Malaria Research, Indian Council of Medical Research, New Delhi, India

    Aditya Arya

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Singh, S., Ansari, M.A. (2022). High Altitude Related Diseases: Milder Effects, HACE, HAPE, and Effect on Various Organ Systems. In: Sharma, N.K., Arya, A. (eds) High Altitude Sickness – Solutions from Genomics, Proteomics and Antioxidant Interventions. Springer, Singapore. https://doi.org/10.1007/978-981-19-1008-1_3

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