Abstract
The accurate, early, and fast detection of breast cancer is important for diagnosis and targeted therapies in cancer patients. Traditionally, after examination through mammograms and other tests (ultrasound, magnetic resonance imaging (MRI)) that confirm alterations in breast tissues, a biopsy is performed for breast cancer diagnosis. A biopsy specimen is a tiny piece of the suspicious breast area that is taken out and tested. However, correct and authentic classification of a breast tumor is a difficult challenge even for experienced pathologists. By the recent advancement in new analytical techniques, it is possible to find new ways in cancer research and diagnostics with promising results. Specifically, the search for lipid biomarkers that appear, increase, or decrease in breast cancer patient compared to the normal healthy person can help in cancer diagnosis. In lipidomics study, all lipids present in a confined biological sample are quantified with the help of analytical instruments. Lipidomics provide knowledge about promising biomarkers for detecting the type and degree of breast cancer. This chapter focuses on the study of lipid biomarkers from breast cancer tissues/plasma samples compared to normal tissues/plasma samples using analytical techniques. The lipid profile study can open new doors for oncology research with prospects to become a tool for routine analyses in diagnostic centers.
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Bibi, N., Yamin, M., Awan, A.T., Ahmad, K., Khattak, R. (2022). Lipid Biomarkers for Breast Cancer Diagnostics. In: Shakil Malik, S., Masood, N. (eds) Breast Cancer: From Bench to Personalized Medicine. Springer, Singapore. https://doi.org/10.1007/978-981-19-0197-3_11
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