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Breast Cancer: From Bench to Personalized Medicine

  • Book
  • © 2022

Overview

Editors:
  1. Saima Shakil Malik

    1. Department of Genetics, Research Division, The University of Alabama, Birmingham, USA

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  2. Nosheen Masood

    1. Department of Biotechnology, Fatima Jinnah Women University, Rawalpindi, Pakistan

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    You can also search for this editor in PubMed   Google Scholar

  • Present etiology, pathogenesis, diagnosis, prognosis, and treatment strategies against breast cancer
  • Reviews the role of non-coding RNA and epigenetic modifications in breast cancer initiation and progression
  • Present non-invasive biomarkers for early detection of breast cancer

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-xvii
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  2. Overview of Breast Cancer

    1. Front Matter

      Pages 1-1
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    2. Epidemiology and Risk Factors of Breast Cancer

      • Tabassum Zafar, Ab Qayoom Naik, Manoj Kumar, Vinoy K. Shrivastava
      Pages 3-29

    3. Histopathological Characteristics: Breast Cancer Subtypes Depending on Receptor Status, Clinical and Pathological Staging of Breast Cancer

      • Pratibha Thakur, Kirti Baraskar, Vinoy K. Shrivastava
      Pages 31-46

    4. Relationship of Breast Cancer with Other Hormone-Sensitive Cancers

      • Rahul Kumar Maurya, Alok Shiomurti Tripathi, Lucy Mohapatra, Shashank Soni, Mohammad Yasir
      Pages 47-71

    5. Cancer Care and Psychosocial Needs

      • Saima K. Beigh, Hira Gul
      Pages 73-83

  3. Cell and Molecular Biology of Breast Cancer (Diagnosis and Prognosis)

    1. Front Matter

      Pages 85-85
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    2. Implications of BRCA1, BRCA2 Gene in Overall Development and Prognosis of Breast Cancer

      • Sheikh Mansoor, Usma Manzoor, Aabid Mustafa Koul, Shahid M. Baba, Ina Amin, Iqra Anwar et al.
      Pages 87-112

    3. Early-Stage Progression of Breast Cancer

      • Hira Gul, Iqra, Nosheen Masood
      Pages 113-123

    4. Noninvasive Biomarkers: Emerging Trends in Early Detection of Breast Cancer

      • Amisha Patel, Sejal Shah
      Pages 125-143

    5. Epigenetics Involvement in Breast Cancer

      • Mariam Ashfaq Khan
      Pages 145-183

    6. Role of Fibrinolytic Mechanisms in Breast Cancer Diagnosis, Prognosis, and Treatment

      • Asma Saleem Qazi, Nosheen Akhtar, Rida Fatima Saeed, Uzma Azeem Awan, Sara Mumtaz
      Pages 185-211

    7. MicroRNAs and Noncoding RNAs as Gene Regulators and Potential Therapeutic Agents

      • Tanzil Juneja, Sejal Shah
      Pages 213-234

    8. Lipid Biomarkers for Breast Cancer Diagnostics

      • Naheed Bibi, Marriam Yamin, Almas Taj Awan, Khalid Ahmad, Rozina Khattak
      Pages 235-262

  4. Breast Cancer Treatment

    1. Front Matter

      Pages 263-263
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    2. Therapeutic Options in BRCA1-Linked Breast Cancer and Systemic Approaches

      • Amir Khan, Ali Jan, Muhammad Qaiser Fatmi
      Pages 265-279

    3. Transcriptional Control Leading to Clinical Outcomes in Breast Cancer Cases

      • Ayesha Aftab, Ranjha Khan, Uzma Hameed, Tanveer Abbas, Bashir Ahmad
      Pages 281-336

    4. Utility of Personalized Medicine in the Treatment of Different Subtypes of Breast Cancer

      • Nosheen Akhtar, Uzma Azeem Awan, Rida Fatima Saeed, Asma Saleem Qazi, Sara Mumtaz, Samina Rubnawaz
      Pages 337-366

    5. Molecular Progression of Breast Cancer and Personalized Medicine in Terms of Clinical Trials

      • Somia Liaqat, Mubashar Hussain, Kiran Aftab, Maryam Khalid, Saima Shakil Malik
      Pages 367-401

    6. Chemotolerance of Breast Cancer and Its Management by Personalized Medicine

      • Yoser Al Rawi, Saima Shakil Malik, Nosheen Masood
      Pages 403-417
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Keywords

About this book

This book provides detailed information on the etiology, pathogenesis, diagnosis, prognosis, and treatment strategies for breast cancer. The first section of the book presents epidemiology, risk factors, histopathological, immunohistochemistry, and molecular subtypes of breast cancer based on the receptor status. It also discusses the association of breast cancer with other hormone-sensitive cancers. The second section of the book covers cover BRCA1 and BRCA2-associated breast carcinogenesis, early-stage progression of breast cancer, and noninvasive biomarkers for the early detection of breast cancer. It also discusses the role of epigenetic modifications and non-coding RNAs in breast cancer metastasis and explores these as the biomarkers and therapeutic targets for breast cancer therapy.


Further, it discusses the role of fibrinolytic mechanisms and circulating tumor cells in breast cancer diagnosis, prognosis, and treatment. The book also provides an update on oral poly(ADP-ribose) polymerase (PARP) inhibitors to treat breast cancer. Finally, it offers potential new options for personalized therapies for breast cancer patients, including optimizing drug dosage and identifying genetic changes associated with cancer symptom occurrence and severity.

Editors and Affiliations

  • Department of Genetics, Research Division, The University of Alabama, Birmingham, USA

    Saima Shakil Malik

  • Department of Biotechnology, Fatima Jinnah Women University, Rawalpindi, Pakistan

    Nosheen Masood

About the editors

Dr. Saima Shakil Malik is currently working as Researcher at Department of Genetics, The University of Alabama at Birmingham. She has obtained her Ph.D. in Biotechnology from Fatima Jinnah Women University, Rawalpindi. Previously she has worked as Scientific Officer at Armed Forces Institute of Pathology Rawalpindi, Assistant Professor at University of Gujrat and Visiting Researcher at the School of Cellular and Molecular Medicine, University of Bristol, UK. Her research interests are focused on Molecular Oncology, emphasizing disease Epidemiology, Post-translational modifications, Epigenetics, DNA repair mechanisms, Drugs associated cytotoxicity, and Gene-environment interaction. She has worked on many research projects funded by national and international organizations. She is also a part of the editorial board of several journals, including Translational Oncology, Cancer Treatment, and Research Communications and current problems in cancer-case reports.


Dr. Nosheen Masood is currently working as an Assistant Professor at the Department of Biotechnology, Fatima Jinnah Women University, Rawalpindi, Pakistan. She completed her Ph.D. in Human Molecular Genetics at the Department of Biosciences at COMSATS University, Islamabad, Pakistan. Her main research interests include molecular biology and cancer genetics, focusing on epidemiological studies, risk assessment, genomic analysis, immunohistochemistry-based diagnostics, and protein-protein interactions. She has been received various prestigious awards, notably, the Research Productivity Award 2014-2015 from the Pakistan Council of Science and Technology (PCST) category D, and Research Productivity Awards from COMSATS Institute of Information Technology for six consecutive years from 2010 to15. She has served as a reviewer for several international journals and has teaching experience in biotechnology, molecular biology, comparative genomics, environmental biology, regulation of geneexpression, and molecular evolution. Dr. Masood has published several research articles in respected, peer-reviewed international journals and authored or co-authored various book chapters.

Bibliographic Information

  • Book Title: Breast Cancer: From Bench to Personalized Medicine

  • Editors: Saima Shakil Malik, Nosheen Masood

  • DOI: https://doi.org/10.1007/978-981-19-0197-3

  • Publisher: Springer Singapore

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2022

  • Hardcover ISBN: 978-981-19-0196-6Published: 15 May 2022

  • Softcover ISBN: 978-981-19-0199-7Published: 16 May 2023

  • eBook ISBN: 978-981-19-0197-3Published: 14 May 2022

  • Edition Number: 1

  • Number of Pages: XVII, 536

  • Number of Illustrations: 1 b/w illustrations

  • Topics: Cancer Research, Genetics and Genomics

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