Abstract
Diabetes is increasing day by day worldwide, and the prevalence of diabetic neuropathy is also increasing accordingly. Diabetic neuropathy causes various symptoms (especially pain) through sensory, motor, and autonomic nervous system abnormalities, leading to severe functional deterioration and reduced quality of life. Neuropathy is the most vital risk factor for diabetic foot ulcers, neuroarthropathy, and amputation. Diabetes causes lesions of the central nervous system as well as peripheral nerves (diabetic leukoencephalopathy). In addition, there are various types of diabetic peripheral neuropathy, and it can appear not only as general damage but also as local damage. The author provides essential information on the causes and pathophysiology of diabetic neuropathy, and the office-based clinical features, diagnosis, and treatment necessary for outpatient treatment, focusing on the most common peripheral symmetric polyneuropathy.
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References
Jensen MP, Chodroff MJ, Dworkin RH. The impact of neuropathic pain on health-related quality of life: review and implications. Neurology. 2007;68(15):1178–82.
Zochodne DW. Diabetes mellitus and the peripheral nervous system: manifestations and mechanisms. Muscle Nerve. 2007;36(2):144–66.
Vinik AI. Diabetic neuropathy: pathogenesis and therapy. Am J Med. 1999;107(2B):17S–26S.
Shy ME, Frohman EM, So YT, et al. Quantitative sensory testing: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology. 2003;60(6):898–904.
Malik RA. The pathology of human diabetic neuropathy. Diabetes. 1997;46(Suppl 2):S50–3.
Veves A, Manes C, Murray HJ, Young MJ, Boulton AJ. Painful neuropathy and foot ulceration in diabetic patients. Diabetes Care. 1993;16(8):1187–9.
Archer AG, Watkins PJ, Thomas PK, Sharma AK, Payan J. The natural history of acute painful neuropathy in diabetes mellitus. J Neurol Neurosurg Psychiatry. 1983;46(6):491–9.
Bril V, England JD, Franklin GM, et al. Evidence-based guideline: treatment of painful diabetic neuropathy—report of the American Association of Neuromuscular and Electrodiagnostic Medicine, the American Academy of Neurology, and the American Academy of Physical Medicine & Rehabilitation. Muscle Nerve. 2011;43(6):910–7.
Tu Y, Lineaweaver WC, Chen Z, Hu J, Mullins F, Zhang F. Surgical decompression in the treatment of diabetic peripheral neuropathy: a systematic review and meta-analysis. J Reconstr Microsurg. 2017;33(3):151–7.
Pinzur MS. Diabetic peripheral neuropathy. Foot Ankle Clin. 2011;16(2):345–9.
Best TJ, Best CA, Best AA, Fera LA. Surgical peripheral nerve decompression for the treatment of painful diabetic neuropathy of the foot—a level 1 pragmatic randomized controlled trial. Diabetes Res Clin Pract. 2019;147:149–56.
Georgescu DE, Mustatea P, Mihalache O, et al. Surgical management of diabetic neuropathy foot complications. Chirurgia (Bucur). 2018;113(5):634–43.
Kluding PM, Pasnoor M, Singh R, et al. The effect of exercise on neuropathic symptoms, nerve function, and cutaneous innervation in people with diabetic peripheral neuropathy. J Diabetes Complications. 2012;26(5):424–9.
Mazilu G, Budurca RA, Graur M, Stamate T. [Surgical treatment of tarsal tunnel syndrome in diabetic neuropathy]. Rev Med Chir Soc Med Nat Iasi 2012;116(1):128–34.
Vinik AI, Erbas T. Diabetic autonomic neuropathy. Handb Clin Neurol. 2013;117:279–94.
Dellon AL. Diabetic neuropathy: medical and surgical approaches. Clin Podiatr Med Surg. 2007;24(3):425–448, viii.
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Pak, C.J. (2022). Diabetic Neuropathy. In: Hong, J.P., Suh, H. (eds) Diabetic Foot Reconstruction. Springer, Singapore. https://doi.org/10.1007/978-981-16-9816-3_3
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DOI: https://doi.org/10.1007/978-981-16-9816-3_3
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