Abstract
Spinal infections encompass a wide group of clinical conditions affecting all age groups with a variety of causative pathogens. These include pyogenic (bacterial), granulomatous infections (prototype being tuberculosis) and parasitic. The clinical presentation of spinal infections may range from subtle symptoms mimicking mechanical back pain to the florid with abscess formation and neurological deficits. The plethora of pathogens, the wide age group affected, and a constellation of symptoms make diagnosis of spinal infection difficult, resulting in delay in treatment often with deleterious consequences. Furthermore, the radiological features of spinal infections maybe similar to other non-infectious clinical entities. Degenerative disease of spine, metastatic disease, osteoporotic fractures, myeloma, and Charcot joints of the spine form the differential diagnosis of spinal infections. Multiple diagnostic tools maybe needed to establish accurate diagnosis. Magnetic Resonance Imaging (MRI) is the imaging modality of choice in diagnosing spinal infections.
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References
Duarte RM, Vaccaro AR. Spinal infection: state of the art and management algorithm. Eur Spine J. 2013;22:2787–99.
Tyrrell PN, Cassar-Pullicino VN, McCall IW. Spinal infection. Eur Radiol. 1999;9(6):1066–77.
Jain AK, Rajasekaran S, Jaggi KR, et al. Tuberculosis of the Spine. Current Concepts Review. J Bone Joint Surg Am. 2020;102:617–28.
An HS, Seldomridge JA. Spinal infections: diagnostic tests and imaging studies. Clin Orthop. 2006;444:27–33.
Tsiodras S, Falagas ME. Clinical assessment and medical treatment of spine infections. Clin Orthop. 2006;444:38–50.
Zimmerli W. Vertebral osteomyelitis. N Engl J Med. 2010;362(11):1022–9.
Colmenero JD, Jimenez-Mejias ME, Sanchez-Lora FJ, et al. Pyogenic, tuberculous, and brucellar vertebral osteomyelitis: a descriptive and comparative study of 219 cases. Ann Rheum Dis. 1997;56:709–15.
Hadjipavlou AG, Mader JT, Necessary JT, et al. Hematogenous pyogenic spinal infections and their surgical management. Spine. 2000;25(13):1668–79.
Carragee EJ. Pyogenic vertebral osteomyelitis. J Bone Joint Surg Am. 1997;79:874–80.
Govender S. Spinal infections. J Bone Joint Surg Br. 2005;87(B):1454–8.
Butler JS, et al. Nontuberculous pyogenic spinal infection in adults: a 12-year experience from a tertiary referral center. Spine. 2006;31(23):2695–700.
Kapeller P, Fazekas F, Krametter D, et al. Pyogenic infectious spondylitis: clinical, laboratory and MRI features. Eur Neurol. 1997;38:94–8.
Priest DH, Peacock JE Jr. Haematogenous vertebral osteomyelitis due to Staphylococcus aureus in the adult: clinical features and therapeutic outcomes. South Med J. 2005;98:854–62.
Dormans JP, Moroz L. Infection and tumors of the spine in children. J Bone Joint Surg. 2007. Suppl 1;89(A):79–97.
Wenger DR, Bobechko WP, Gilday DL. The spectrum of intervertebral disc space infection in children. J Bone Joint Surg Am. 1978;60:100–8.
Digby JM, Kersley JB. Pyogenic nontuberculous spinal infection. J Bone Joint Surg Br. 1979;61:47–55.
Emery SE, Chan DP, Woodward HR. Treatment of hematogenous pyogenic vertebral osteomyelitis with anterior debridement and primary bone grafting. Spine. 1989;14:284–91.
Rath SA, Neff U, Schneider O, Richter HP. Neurosurgical management of thoracic and lumbar vertebral osteomyelitis and discitis in adults: a review of 43 consecutive surgically treated patients. Neurosurgery. 1996;38:926–33.
Schulitz KP, Assheuer J. Discitis after procedures on the intervertebral disc. Spine. 1994;19:1172–7.
Fernandez M, Carrol CL, Baker CJ. Discitis and vertebral osteomyelitis in children: an 18-year review. Pediatrics. 2000;105:1299–304.
Rothman SLG. The diagnosis of spinal Infections. Orth Clin North America. 1996;27(1):15–31.
José M, Mellado L, del Palomar P, et al. MR imaging of spinal infection: atypical features, interpretative pitfalls and potential mimickers. Eur Radiol. 2004;14:1980–9.
Smids C, Kouijzer IJ, Vos FJ, et al. A comparison of the diagnostic value of MRI and 18F-FDG-PET/CT in suspected spondylodiscitis. Infection. 2017;45(1):41–9.
Melton LJ 3rd, Lane AW, Cooper C, et al. Prevalence and incidence of vertebral deformities. Osteoporos Int. 1993;3:113–9.
Eastell R, Cedel SL, Wahner HW, et al. Classification of vertebral fractures. J Bone Miner Res. 1991;6:207–15.
Oda K, Shibayama Y, Abe M, Onomura T. Morphogenesis of vertebral deformities in involutional osteoporosis. Age-related, three-dimensional trabecular structure. Spine. 1998;23:1050–6.
Link TM, Guglielmi G, van Kuijk C, et al. Radiologic assessment of osteoporotic vertebral fractures: diagnostic and prognostic implications. Eur Radiol. 2005;15(8):1521–32.
Modic MT, Steinberg PM, Ross JS, et al. Degenerative disc disease: assessment of changes in vertebral body marrow with MR imaging. Radiology. 1988;166:193–9.
Charran K, Tony G, Lalam R, Tyrrell PNM, et al. Destructive discovertebral degenerative disease of the lumbar spine. Skelet Radiol. 2012;41:1213–21.
Venkateswaran L, Rodriguez-Galindo C, Merchant TE, et al. Primary Ewing tumor of the vertebrae: clinical characteristics, prognostic factors, and outcome. Med Pediatr Oncol. 2001;37:30–5.
Yeom JS, Lee CK, Shin HY, Lee CS, Han CS, Chang H. Langerhans’ cell histiocytosis of the spine. Analysis of twenty-three cases. Spine. 1999;24:1740–9.
Garg S, Mehta S, Dormans JP. Langerhans cell histiocytosis of the spine in children. Long-term follow-up. J Bone Joint Surg Am. 2004;86:1740–50.
Chan RLS, Chan CH, Chan HF, et al. The many facets of neuropathic arthropathy. BJR Open. 2019;1(1):20180039.
Standaert C, Cardenas DD, Anderson P. Charcot spine as a late complication of traumatic spinal cord injury. Arch Phys Med Rehabil. 1997;78:221–5.
Lacout A, Lebreton C, Mompoint D, et al. CT and MRI of spinal neuroarthropathy. Am J Roentgenol. 2009;193:W505–14.
Acknowledgments
The authors would wish to express their sincerest thanks to Dr. Jaspreet Singh, Consultant Radiologist at the Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, for his kind contribution of the imaging utilized in this chapter.
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Trivedi, J., Trivedi, R. (2022). Differential Diagnosis of Spinal Infections. In: Dhatt, S.S., Kumar, V. (eds) Tuberculosis of the Spine. Springer, Singapore. https://doi.org/10.1007/978-981-16-9495-0_11
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