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Nutraceuticals as Therapeutic Agents for Prevention and Treatment of Diseases

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Prebiotics, Probiotics and Nutraceuticals

Abstract

Nutraceutical means nutrient and pharmaceutical, also known as medicinal/designer/functional foods as well as phytochemicals. These are the supplements of nutritional value which include daily products like dietary products, genetically modified products, herbal products, bio-yoghurts, vitamins, and fortified cereals. These medicinal or nutraceutical foods are originated from plant sources (garlic, ginger, onion, turmeric), dietary fiber and enzymes like papain and bromelain, various hydrolyzed proteins, and phytonutrients. Traditional nutraceuticals include phytochemicals, probiotic bacteria, enzymes, chemical compounds, nutrients, and plants. Recent investigations have shown that these compounds have promising outcomes in different pathological problems like cancer, diabetes, cardiovascular diseases, and atherosclerosis. These situations involve various changes like redox state alteration, and to counteract this situation, most of the nutraceuticals possess potential toward antioxidant activity. Thus, they are observed as safe sources for promotion of health, mainly to prevent different life-threatening diseases like diabetes, infection, and renal and gastrointestinal disorders, and play a vital role in food and pharmaceutical industries in maintaining life quality, good health, and longevity. Health professionals and nutritionists should research and work together for the benefit of mankind. Further, allocation of nutraceuticals can be done on the basis of sources of food, their action mechanism, chemical nature, etc. Interest in nutraceuticals is growing rapidly due to the rapid advances in prevention of diseases and healthcare product costs and elderly people using regular food industrial products which allow the enlargement in medicinal premium food products which are marketed to health-conscious people. They offer a great scope, and it is required to execute clinical trials for supplying nutraceuticals which generate huge benefits to customers and service providing companies. Recent trends show that nutraceuticals offer promising results in healthcare sector and nutraceutical consumption is increasing in global market day by day. In the present chapter, much work has been devoted to focus on the recent trends in herbal nutraceuticals for the prevention of cardiovascular disease, cancer, diabetes, hypertension, and arthritis disease.

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References

  • Abbas S, Linseisen J, Rohrmann S, Beulens JW, Buijsse B, Amiano P et al (2014) Dietary vitamin D intake and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition: the EPIC-InterAct study. Eur J Clin Nutr 68(2):196–202

    Article  CAS  PubMed  Google Scholar 

  • Adak M, da Silva JA (2010) Garlic [Allium sativum] and its beneficial effect on cardiovascular disease: a review. Int J Biomed Pharm Sci 4(1):1–20

    Google Scholar 

  • Agbabiaka TB, Pittler MH, Wider B, Ernst E (2009) Serenoarepens: a systematic review of adverse events. Drug Saf 32(8):637–647

    Article  PubMed  Google Scholar 

  • American Diabetes Association (2007) Nutrition recommendations and interventions for diabetes (position statement). Diabetes Care 30(Suppl 1):S48–S65

    Article  CAS  Google Scholar 

  • American Diabetes Association (2019) Diabetes Care 42(Supplement 1):S46–S60

    Article  Google Scholar 

  • Aparicio-Soto M, Redhu D, Sánchez-Hidalgo M, Fernández-Bolaños JG, Alarcón-de-la-Lastra C et al (2019) Olive-oil-derived polyphenols effectively attenuate inflammatory responses of human keratinocytes by interfering with the NF-κB pathway. Mol Nutr Food Res 63(21):1900019

    Article  CAS  Google Scholar 

  • Aportela-Palacios A, Sosa-Morales ME, Vélez-Ruiz JF (2005) Rheological and physicochemical behavior of fortified yogurt, with fiber and calcium. J Texture Stud 36(3):333–349

    Article  Google Scholar 

  • Arora M, Sharma S, Baldi A (2013) Comparative insight of regulatory guidelines for probiotics in USA, India and Malaysia: a critical review. Int J Biotechnol Wellness Ind 2(2):51–64

    CAS  Google Scholar 

  • Bacanli M, Başaran N, Başaran AA (2017) Lycopene: is it beneficial to human health as an antioxidant? Turk J Pharm Sci 14(3):311

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bagchi D (2006) Nutraceuticals and functional foods regulations in the United States and around the world. Toxicology 221(1):1–3

    Article  CAS  PubMed  Google Scholar 

  • Bahadoran Z, Mirmiran P, Azizi F (2013) Dietary polyphenols as potential nutraceuticals in management of diabetes: a review. J Diabetes Metab Disord 12(1):43

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bajaj S, Khan A (2012) Antioxidants and diabetes. Indian J Endocrinol Metabol 16(Suppl 2):267

    Article  CAS  Google Scholar 

  • Bantle JP, Wylie-Rosett J, Albright AL et al (2008) Nutrition recommendations and interventions for diabetes: a position statement of the American Diabetes Association. Diabetes Care 31(Suppl 1):S61–S78

    CAS  PubMed  Google Scholar 

  • Bartlett HE, Eperjesi F (2008) Nutritional supplementation for type 2 diabetes: A systematic review. Ophthalmic Physiol Opt 28(6):503–523

    Article  PubMed  Google Scholar 

  • Bhatt T, Patel K (2020) Carotenoids: potent to prevent diseases review. Nat Prod Bioprospect 10(3):109

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Burger KNJ, Beulens JWJ, van der Schouw YT, Sluijs I, Spijkerman AMW, Sluik D et al (2012) Dietary fiber, carbohydrate quality and quantity, and mortality risk of individuals with diabetes mellitus. PLoS ONE 7(8):e43127

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Calo LA, Pagnin E, Davis PA et al (2006) Antioxidant effect of L-carnitine and its short chain esters: relevance for the protection from oxidative stress related cardiovascular damage. Int J Cardiol 107(1):54–60

    Article  PubMed  Google Scholar 

  • Calvani M, Pasha A, Favre C (2020) Nutraceutical boom in cancer: inside the labyrinth of reactive oxygen species. Int J Mol Sci 21(6):1936

    Article  CAS  PubMed Central  Google Scholar 

  • Cameron M, Gagnier JJ, Chrubasik S (2011) Herbal therapy for treating rheumatoid arthritis. Cochrane Database Syst Rev 8:CD002948

    Google Scholar 

  • Canadian Minister of National Health and Welfare Nutrition Recommendations (1990) The report of the scientific review committee. Canadian Government Publishing Centre, Ottawa

    Google Scholar 

  • Caughey GE, Mantzioris E, Gibson RA, Cleland LG, James MJ (1996) The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil. Am J Clin Nutr 63(1):116–122

    Article  CAS  PubMed  Google Scholar 

  • Caughey GE, James MJ, Proudman SM, Cleland LG (2010) Fish oil supplementation increases the cyclooxygenase inhibitory activity of paracetamol in rheumatoid arthritis patients. Complement Ther Med 18(3-4):171–174

    Article  PubMed  Google Scholar 

  • Chan PS, Caron JP, Orth MW (2005) Effect of glucosamine and chondroitin sulfate on regulation of gene expression of proteolytic enzymes and their inhibitors in interleukin-1-challenged bovine articular cartilage explants. Am J Vet Res 66:1870–1876

    Article  CAS  PubMed  Google Scholar 

  • Chen H, Karne RJ, Hall G et al (2006) High-dose oral vitamin C partially replenishes vitamin C levels in patients with type 2 diabetes and low vitamin C levels but does not improve endothelial dysfunction or insulin resistance. Am J Physiol Heart Circ Physiol 290(1):137–145

    Article  CAS  Google Scholar 

  • Chou MM, Vergnolle N, McDougall JJ, Wallace JL, Marty S et al (2005) Effects of chondroitin and glucosamine sulfate in a dietary bar formulation on inflammation, interleukin-1beta, matrix metalloprotease-9, and cartilage damage in arthritis. Exp Biol Med 230:255–262

    Article  CAS  Google Scholar 

  • Chun KS, Kundu J, Kundu JK, Surh YJ (2014) Targeting Nrf2-Keap1 signaling for chemoprevention of skin carcinogenesis with bioactive phytochemicals. Toxicol Lett 229(1):73–84

    Article  CAS  PubMed  Google Scholar 

  • Cleland LG, James MJ, Proudman SM (2003) The role of fish oils in the treatment of rheumatoid arthritis. Drugs 63(9):845–853

    Article  CAS  PubMed  Google Scholar 

  • Costello RB, Dwyer JT, Bailey RL (2016) Chromium supplements for glycemic control in type 2 diabetes: limited evidence of effectiveness. Nutr Rev 74(7):455–468

    Article  PubMed  PubMed Central  Google Scholar 

  • Das L, Vinayak M (2015) Long term effect of curcumin in restoration of tumour suppressor p53 and phase-II antioxidant enzymes via activation of NRF2 signalling and modulation of inflammation in prevention of cancer. PLoS ONE 10:e0124000

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Das L, Bhaumik E, Raychaudhuri U, Chakraborty R (2012a) Role of nutraceuticals in human health. J Food Sci Technol 49(2):173–183

    Article  CAS  PubMed  Google Scholar 

  • Das L, Bhaumik E, Raychaudhuri U, Chakraborty R (2012b) Role of nutraceuticals in human health. J Food Sci Technol 49(2):173–183

    Article  CAS  PubMed  Google Scholar 

  • Derosa G, Limas CP, Macías PC, Estrella A, Maffioli P (2014) Dietary and nutraceutical approach to type 2 diabetes. Arch Med Sci 10(2):336

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Deutsch L (2007) Evaluation of the effect of Neptune krill oil on chronic inflammation and arthritic symptoms. J Am Coll Nutr 26(1):39–48

    Article  CAS  PubMed  Google Scholar 

  • Diaz-Gerevini GT, Repossi G, Dain A, Tarres MC, Das UN, Eynard AR (2016) Beneficial action of resveratrol: how and why? Nutrition 32(2):174–178

    Article  CAS  PubMed  Google Scholar 

  • Dibaba DT, Xun P, Fly AD, Yokota K, He K (2014) Dietary magnesium intake and risk of metabolic syndrome: a meta-analysis. Diabet Med 31(11):1301–1309

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dubey P, Thakur V, Chattopadhyay M (2020) Role of minerals and trace elements in diabetes and insulin resistance. Nutrients 12(6):1864

    Article  CAS  PubMed Central  Google Scholar 

  • Engwa GA (2018) Free radicals and the role of plant phytochemicals as antioxidants against oxidative stress-related diseases. Phytochemicals 2018:49–73

    Google Scholar 

  • Ernst E (2003) Avocado–soybean unsaponifiables (ASU) for osteoarthritis–a systematic review. Clin Rheumatol 22(4-5):285–288

    Article  CAS  PubMed  Google Scholar 

  • Flint HJ, Scott KP, Louis P, Duncan SH (2012) The role of the gut microbiota in nutrition and health. Nat Rev Gastroenterol Hepatol 9(10):577

    Article  CAS  PubMed  Google Scholar 

  • Fortin PR, Lew RA, Liang MH, Wright EA, Beckett LA et al (1995) Validation of a meta-analysis: the effects of fish oil in rheumatoid arthritis. J Clin Epidemiol 48(11):1379–1390

    Article  CAS  PubMed  Google Scholar 

  • Fransen M, Agaliotis M, Nairn L, Votrubec M, Bridgett L et al (2014) Glucosamine and chondroitin for knee osteoarthritis: A double-blind randomised placebo-controlled clinical trial evaluating single and combination regimens. Ann Rheum 74:851–858

    Article  CAS  Google Scholar 

  • Franzini L, Ardigo D, Zavaroni I (2008) Dietary antioxidants and glucose metabolism. Curr Opin Clin Nutr Metab Care 11(4):471–476

    Article  CAS  PubMed  Google Scholar 

  • Gao X, Liu X, Xu J, Xue C, Xue Y, Wang Y (2014) Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet. J Biosci Bioeng 118(4):476–481

    Article  CAS  PubMed  Google Scholar 

  • Gray A, Threlkeld RJ (2019) Nutritional recommendations for individuals with diabetes. In: Endotext. MDText.com, Inc., South Dartmouth

    Google Scholar 

  • Han G, Xia J, Gao J, Inagaki Y, Tang W, Kokudo N (2015) Anti-tumor effects and cellular mechanisms of resveratrol. Drug Discoveries Therap 9(1):1–2

    Article  CAS  Google Scholar 

  • Harris WS, Park Y, Isley WL (2003) Cardiovascular disease and long-chain omega-3 fatty acids. Curr Opin Lipidol 14:9–14

    Article  CAS  PubMed  Google Scholar 

  • Hathcock J (2001) Dietary supplement: how they are used and regulated. J Nutr 131(3):1114–1117

    Article  Google Scholar 

  • Henrotin Y, Mobasheri A, Marty M (2012) Is there any scientific evidence for the use of glucosamine in the management of human osteoarthritis? Arthritis Res Ther 14:201

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Heyland DK (2001) In search of the magic nutraceutical: problems with current approaches. J Nutr 131(9):2591

    Article  Google Scholar 

  • Higgins JA (2004) Resistant starch: metabolic effects and potential health benefits. J AOAC Int 87(3):761–768

    Article  CAS  PubMed  Google Scholar 

  • Hochberg MC (2010) Structure-modifying effects of chondroitin sulfate in knee osteoarthritis: an updated meta-analysis of randomized placebo-controlled trials of 2-year duration. Osteoarthr Cartil 18:28–31

    Article  Google Scholar 

  • Ierna M, Kerr A, Scales H, Berge K, Griinari M (2010) Supplementation of diet with krill oil protects against experimental rheumatoid arthritis. BMC Musculoskelet Disord 11(1):136

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jadhav D, Deshpande D, Ramaa CS, Kadam VJ (2006) Nutraceuticals and functional foods: a new era in health and disease management. Indian J Pharm Educ Res 40(3):190

    Google Scholar 

  • Johnson MM, Swan DD, Surette ME, Stegner J, Chilton T, Fonteh AN, Chilton FH (1997) Dietary supplementation with γ-linolenic acid alters fatty acid content and eicosanoid production in healthy humans. J Nutr 127(8):1435–1444

    Article  CAS  PubMed  Google Scholar 

  • Kalra EK (2003) Nutraceutical-definition and introduction. AAPS PharmSci 5(3):27–28

    Article  PubMed Central  Google Scholar 

  • Katakwar P, Metgud R, Naik S, Mittal R (2016) Oxidative stress marker in oral cancer: a review. J Cancer Res Ther 12(2):438

    Article  CAS  PubMed  Google Scholar 

  • Kochhar KP (2008) Dietary spices in health and diseases: I. Indian J Physiol Pharmacol 52(2):106–122

    CAS  PubMed  Google Scholar 

  • Kontessis P, Jones S, Dodds R et al (1990) Renal, metabolic and hormonal responses to ingestion of animal and vegetable proteins. Kidney Int 38(1):136–144

    Article  CAS  PubMed  Google Scholar 

  • Kopustinskiene DM, Jakstas V, Savickas A, Bernatoniene J (2020) Flavonoids as anticancer agents. Nutrients 12(2):457

    Article  CAS  PubMed Central  Google Scholar 

  • Kumar K, Kumar S (2015) Role of nutraceuticals in health and disease prevention: a review. South Asian J Food Technol Environ 1:116–121

    Article  Google Scholar 

  • Kunnumakkara AB, Sailo BL, Banik K, Harsha C, Prasad S et al (2018) Chronic diseases, inflammation, and spices: how are they linked? J Transl Med 16(1):14

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lau FC, Bagchi M, Sen CK et al (2008) Nutrigenomic basis of beneficial effects of chromium (III) on obesity and diabetes. Mol Cell Biochem 317(1-2):1–10

    Article  CAS  PubMed  Google Scholar 

  • Li Y, Li S, Meng X, Gan RY, Zhang JJ, Li HB (2017) Dietary natural products for prevention and treatment of breast cancer. Nutrients 9(7):728

    Article  CAS  PubMed Central  Google Scholar 

  • Liu M, Jeong EM, Liu H, Xie A, So EY et al (2019) Magnesium supplementation improves diabetic mitochondrial and cardiac diastolic function. JCI Insight 4(1):e123182

    Article  PubMed Central  Google Scholar 

  • Lobo V, Patil A, Phatak A, Chandra N (2010) Free radicals, antioxidants and functional foods: impact on human health. Pharmacogn Rev 4(8):118

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Loseli M, Awwad GE, Bradshaw AR (2015) A review of nutraceuticals in joint arthritis. J Pain Relief 4:180

    Google Scholar 

  • Maheu E, Mazières B, Valat JP, Loyau G, Loët XL et al (1998) Symptomatic efficacy of avocado/soybean unsaponifiables in the treatment of osteoarthritis of the knee and hip: a prospective, randomized, double-blind, placebo-controlled, multicenter clinical trial with a six-month treatment period and a two-month follow-up demonstrating a persistent effect. Arthritis Rheum 41(1):81–91

    Article  CAS  PubMed  Google Scholar 

  • McAlindon TE, Bannuru R, Sullivan MC, Arden NK, Berenbaum F et al (2014) OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthr Cartil 22(3):363–388

    Article  CAS  Google Scholar 

  • Milani A, Basirnejad M, Shahbazi S, Bolhassani A (2017) Carotenoids: biochemistry, pharmacology and treatment. Br J Pharmacol 174(11):1290–1324

    Article  CAS  PubMed  Google Scholar 

  • Mozaffarian D (2016) Dietary and policy priorities for cardiovascular disease, diabetes, and obesity: a comprehensive review. Circulation 133(2):187–225

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Muñoz-Garach A, García-Fontana B, Muñoz-Torres M (2019) Vitamin D status, calcium intake and risk of developing type 2 diabetes: an unresolved issue. Nutrients 11(3):642

    Article  CAS  PubMed Central  Google Scholar 

  • Musial C, Kuban-Jankowska A, Gorska-Ponikowska M (2020) Beneficial properties of green tea catechins. Int J Mol Sci 21(5):1744

    Article  CAS  PubMed Central  Google Scholar 

  • Navneet T, Gupta BP, Nagariya AK, Jain NP, Jitendra B, Surendra J (2010) Nutraceutical: new era’s safe pharmaceuticals. J Pharm Res 3(6):1243–1247

    Google Scholar 

  • Nimesh S, Nimesh VD (2018) Nutraceuticals in the management of diabetes mellitus. Pharm Pharmacol Int J 6(2):114–120

    Google Scholar 

  • Nivya MA, Kaliyappan R, Vel K, Sasidharan S, Seethpathy GS (2012) Role of nutraceutical in cancer. Int J Pharm Pharm Sci 4:14–17

    Google Scholar 

  • Nuttall FQ, Gannon MC (1991) Plasma glucose and insulin response to macronutrients in nondiabetic and NIDDM subjects. Diabetes Care 14(9):824–838

    Article  CAS  PubMed  Google Scholar 

  • Orth MW, Peters TL, Hawkins JN (2002) Inhibition of articular cartilage degradation by glucosamine-HCl and chondroitin sulphate. Equine Vet J 34(S34):224–229

    Article  Google Scholar 

  • Patel S (2015) Emerging trends in nutraceutical applications of whey protein and its derivatives. J Food Sci Technol 52(11):6847–6858

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rajasekar P, Anuradha CV (2007) Effect of L-carnitine on skeletal muscle lipids and oxidative stress in rats fed high fructose diet. Exp Diabetes Res 2007:72741

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rajasekaran A, Sivagnanam G, Xavier R (2008) Nutraceuticals as therapeutic agents: a review. Res J Pharm Technol 1(4):328–340

    CAS  Google Scholar 

  • Ramaa CS, Shirode AR, Mundada AS, Kadam VJ (2006) Nutraceuticals-an emerging era in the treatment and prevention of cardiovascular diseases. Curr Pharm Biotechnol 7(1):15–23

    Article  CAS  PubMed  Google Scholar 

  • Reichenbach S, Sterchi R, Scherer M, Trelle S, Bürgi E et al (2007) Meta-analysis: chondroitin for osteoarthritis of the knee or hip. Ann Intern Med 146(8):580–590

    Article  PubMed  Google Scholar 

  • Riccioni G, Bucciarelli T, Mancini B et al (2007) Antioxidant vitamin supplementation in cardiovascular diseases. Ann Clin Lab Sci 37(1):89–95

    CAS  PubMed  Google Scholar 

  • Richy F, Bruyere O, Ethgen O, Cucherat M, Henrotin Y et al (2003) Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Arch Intern Med 163:1514–1522

    Article  CAS  PubMed  Google Scholar 

  • Rizzo AM, Berselli P, Zava S, Montorfano G, Negroni M et al (2010) Endogenous antioxidants and radical scavengers. In: Bio-farms for nutraceuticals. Springer, Boston, MA, pp 52–67

    Chapter  Google Scholar 

  • Ross S (2000) Functional foods: the food and drug administration perspectives. Am J Clin Nutr 71(6):1735

    Article  Google Scholar 

  • Russell WR, Baka A, Björck I, Delzenne N, Gao D, Griffiths HR et al (2016) Impact of diet composition on blood glucose regulation. Crit Rev Food Sci Nutr 56(4):541–590

    Article  CAS  PubMed  Google Scholar 

  • Sahin K, Ali S, Sahin N, Orhan C, Kucuk O (2016) Lycopene: multitargeted applications in cancer therapy. Nat Prod Cancer Drug Discovery 2016:79–108

    Google Scholar 

  • Salehi B, Mishra AP, Nigam M, Sener B, Kilic M, Sharifi-Rad M, Fokou PV, Martins N, Sharifi-Rad J (2018) Resveratrol: a double-edged sword in health benefits. Biomedicine 6(3):91

    CAS  Google Scholar 

  • Santini A, Cammarata SM, Capone G, Ianaro A, Tenore GC et al (2018) Nutraceuticals: opening the debate or a regulatory framework. Br J Clin Pharmacol 84(4):659–672

    Article  PubMed  PubMed Central  Google Scholar 

  • Sievenpiper JL, Chan CB, Dworatzek PD, Freeze C, Williams SL (2018) Nutrition therapy. Can J Diabetes 42:64–79

    Article  Google Scholar 

  • Singh RB, Niaz MA, Rastogi SS et al (1999) Effect of hydro soluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. J Hum Hypertens 13(3):203–208

    Article  CAS  PubMed  Google Scholar 

  • Singh JA, Christensen R, Wells GA, Suarez-Almazor ME, Buchbinder R et al (2009) Biologics for rheumatoid arthritis: an overview of Cochrane reviews. Cochrane Database Syst Rev 4:CD007848

    Google Scholar 

  • Siri-Tarino PW, Sun Q, Hu FB, Krauss RM (2010) Saturated fatty acids and risk of coronary heart disease: modulation by replacement nutrients. Curr Atheroscler Rep 12(6):384–390

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Snow W (2006) Managing editor with diabetes. Surging some look for alternative treatment

    Google Scholar 

  • Takeshima M, Ono M, Higuchi T, Chen C, Hara T, Nakano S (2014) Anti-Proliferative and apoptosis-inducing activity of lycopene against three subtypes of human breast cancer cell lines. Cancer Sci 105:252–257

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tanaka M, Misawa E, Yamauchi K, Abe F, Ishizaki C (2015) Effects of plant sterols derived from Aloe vera gel on human dermal fibroblasts in vitro and on skin condition in Japanese women. Clin Cosmet Investig Dermatol 8:95

    Article  PubMed  PubMed Central  Google Scholar 

  • Tomeh MA, Hadianamrei R, Zhao X (2019) A review of curcumin and its derivatives as anticancer agents. Int J Mol Sci 20(5):1033

    Article  CAS  PubMed Central  Google Scholar 

  • Trejo-Solís C, Pedraza-Chaverrí J, Torres-Ramos M, Jiménez-Farfán D, Cruz Salgado A et al (2013) Multiple molecular and cellular mechanisms of action of lycopene in cancer inhibition. Evid Based Complement Alternat Med 2013:705121

    Article  PubMed  PubMed Central  Google Scholar 

  • Treviño S, Díaz A, Sánchez-Lara E, Sanchez-Gaytan BL, Perez-Aguilar JM et al (2019) Vanadium in biological action: chemical, pharmacological aspects, and metabolic implications in diabetes mellitus. Biol Trace Elem Res 188(1):68–98

    Article  CAS  PubMed  Google Scholar 

  • Trifković K, Benković M (2019) Introduction to nutraceuticals and pharmaceuticals. In: Nutraceuticals and natural product pharmaceuticals. Academic Press, Cambridge, pp 1–31

    Google Scholar 

  • Vargas-Mendoza N, Morales-González Á, Madrigal-Santillán EO, Madrigal-Bujaidar E, Álvarez-González I et al (2019) Antioxidant and adaptative response mediated by Nrf2 during physical exercise. Antioxidants 8(6):196

    Article  CAS  PubMed Central  Google Scholar 

  • Wallace TC, Slavin M, Frankenfeld CL (2016) Systematic review of anthocyanins and markers of cardiovascular disease. Nutrients 8(1):32

    Article  CAS  PubMed Central  Google Scholar 

  • Whitman MM (2001) Understanding the perceived need for complementary and alternative nutraceuticals: lifestyle issues. Clin J Oncol Nurs 5:5

    Google Scholar 

  • Xin W, Wei W, Lin Z, Zhang X, Yang H et al (2013) Fish oil and atrial fibrillation after cardiac surgery: a meta-analysis of randomized controlled trials. PLoS One 8(9):e72913

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Xiong YX, Su HF, Lv P, Ma Y, Wang SK, Miao H et al (2015) A newly identified berberine derivative induces cancer cell senescence by stabilizing endogenous G-quadruplexes and sparking a DNA damage response at the telomere region. Oncotarget 6(34):35625

    Article  PubMed  PubMed Central  Google Scholar 

  • Yahfoufi N, Alsadi N, Jambi M, Matar C (2018) The immunomodulatory and anti-inflammatory role of polyphenols. Nutrients 10(11):1618

    Article  CAS  PubMed Central  Google Scholar 

  • Yang Y, Dong JY, Cui R, Muraki I, Yamagishi K et al (2020) Japan Public Health Center-based Prospective Study Group Consumption of flavonoid-rich fruits and risk of coronary heart disease: a prospective cohort study. Br J Nutr 9:1–26

    Google Scholar 

  • Yao LH, Jiang YM, Shi J, Tomas-Barberan FA, Datta N et al (2004) Flavonoids in food and their health benefits. Plant Foods Hum Nutr 59(3):113–122

    Article  CAS  PubMed  Google Scholar 

  • Zeisel SH (1999) Regulation of nutraceuticals. Science 285:185–186

    Article  Google Scholar 

  • Zhang YJ, Gan RY, Li S, Zhou Y, Li AN et al (2015) Antioxidant phytochemicals for the prevention and treatment of chronic diseases. Molecules 20(12):21138–21156

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zheng J, Zhou Y, Li Y, Xu DP, Li S, Li HB (2016) Spices for prevention and treatment of cancers. Nutrients 8:495

    Article  CAS  PubMed Central  Google Scholar 

  • Ziegler D, Reljanovic M, Mehnert H et al (1999) Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials. Exp Clin Endocrinol Diabetes 107(7):421–430

    Article  CAS  PubMed  Google Scholar 

  • Zurier RB, Rossetti RG, Jacobson EW, Demarco DM, Liu NY et al (1996) Gamma-linolenic acid treatment of rheumatoid arthritis A randomized, placebo-controlled trial. Arthritis Rheum 39(11):1808–1817

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Chemistry, University of Rajasthan, Jaipur, India

    Harshita Sachdeva

  2. Department of Chemistry, School of Liberal Arts and Sciences, Mody University of Science and Technology, Laxmangarh, Rajasthan, India

    Sarita Khaturia

  3. Department of Chemistry, Nalanda College of Engineering, Nalanda, Bihar, India

    Mamta Chahar

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  1. Fakir Mohan University, Vyasa Vihar, Balasore, Odisha, India

    Kambaska Kumar Behera

  2. Department of Zoology, University of Rajasthan, Jaipur, Rajasthan, India

    Renu Bist

  3. ICAR-National Rice Research Institute, Bidyadharpur, Cuttack, Odisha, India

    Sangita Mohanty

  4. Department of Zoology, Fakir Mohan University, Vyasa Vihar, Balasore, Odisha, India

    Manojit Bhattacharya

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Sachdeva, H., Khaturia, S., Chahar, M. (2022). Nutraceuticals as Therapeutic Agents for Prevention and Treatment of Diseases. In: Behera, K.K., Bist, R., Mohanty, S., Bhattacharya, M. (eds) Prebiotics, Probiotics and Nutraceuticals. Springer, Singapore. https://doi.org/10.1007/978-981-16-8990-1_4

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