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Discovery of Hepatitis Viruses and Two Nobel Prizes: A Tale of Keen Observations, Serendipity, Collaborative Research, Astute Interpretations and Game-Changing Innovations

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Biomedical Translational Research

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Abstract

Chronic viral hepatitis, caused by hepatitis B and hepatitis C viruses, is one of the most common causes of end-stage liver disease and liver cancer in the world, and accounts for almost 4000 deaths per day. Fundamental research in chronic viral hepatitis has led to dramatic changes in its diagnosis, prevention and management. Indeed, the scientists credited with the discovery of hepatitis B (Baruch Blumberg) and hepatitis C (Harvey J. Alter, Michael Houghton and Charles M. Rice) were honoured with the Nobel Prize in 1976 and 2020, respectively. The story of the unravelling of the mysteries behind “serum hepatitis” and the establishment of its viral aetiology is an incredible testament to the remarkable accomplishments of modern biomedical research. In this chapter, we embark on a journey into the discovery of hepatitis B and C viruses, discuss the work of the Nobel laureates and throw light on the work of the unsung heroes without whose contributions, the discoveries may never have seen the light of day.

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Author information

Authors and Affiliations

  1. Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

    Arka De & Yogesh K. Chawla

  2. Kalinga Institute of Medical Sciences (KIMS), Bhubaneshwar, India

    Yogesh K. Chawla

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  1. Arka De
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  2. Yogesh K. Chawla
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Editor information

Editors and Affiliations

  1. Department of Biotechnology, Punjab University, Chandigarh, India

    R.C. Sobti

  2. Department of Pathology, University of Miami Health System, Florida, USA

    Awtar Krishan Ganju

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De, A., Chawla, Y.K. (2022). Discovery of Hepatitis Viruses and Two Nobel Prizes: A Tale of Keen Observations, Serendipity, Collaborative Research, Astute Interpretations and Game-Changing Innovations. In: Sobti, R., Ganju, A.K. (eds) Biomedical Translational Research. Springer, Singapore. https://doi.org/10.1007/978-981-16-8845-4_9

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