Skip to main content
SpringerLink
Log in

Coupling of Mechanical Deformation and Electrophysiology of Brain Neuron Cell

  • Conference paper
  • First Online:
Advances in Structural Integrity

Part of the book series: Lecture Notes in Mechanical Engineering ((LNME))

  • 553 Accesses

Abstract

Traumatic brain injury (TBI), due to a vicious head impact in motor or space vehicle accidents, falls, and sports injuries, causes severe tissue deformation. The impact forces make the brain tissue distorted, twisted, and injured. Due to the impact, the stress inhomogeneity creates highly nonuniform strains and deforms the axons in the white matter. For more than half a century, electrophysiology of brain neurons was considered pure electrical phenomenon. However, recent experimental studies show that mechanical deformation plays a vital role in brain neuron’s electrophysiology. In this work, we model the finite deformation-based coupling of mechanical deformation with the Hodgkin-Huxley (H-H) model of neuron electrophysiology. The sensitivity of stretching on the membrane potential and the generated electrical field is demonstrated.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Dewan MC, Rattani A, Gupta S, Baticulon RE, Hung YC, Punchak M,Agrawal A, Adeleye AO, Shrime MG, Rubiano AM, Rosenfeld JV, Park KB (2018) Estimating the global incidence of traumatic brain injury. J Neurosurg JNS 130(4)

    Google Scholar 

  2. Carter R (2019) The brain book: an illustrated guide to its structure, functions, and disorders

    Google Scholar 

  3. Budday S, Sommer G, Birkl CR, Langkammer C, Haybaeck J, Kohnert JD, Bauer M, Paulsen F, Steinmann P, Kuhl E, Holzapfel GA (2017) Mechanical characterization of human brain tissue. Acta Biomater 48:319–340

    Google Scholar 

  4. Zhao H, Yin Z, Li K, Liao Z, Xiang H, Zhu F (2016) Mechanical characterization of immature porcine brainstem in tension at dynamic strain rates. Med Sci Monit Basic Res

    Google Scholar 

  5. Prange MT, Margulies SS (2002) Regional, directional, and age-dependent properties of the brain undergoing large deformation. J Biomech Eng 124(2):244–252

    Google Scholar 

  6. Haldar K, Pal C (2018) Rate dependent anisotropic constitutive modeling of brain tissue undergoing large deformation. J Mech Behav Biomed Mater 81:178–194

    Google Scholar 

  7. Velardi F, Fraternali F, Angelillo M (2006) Anisotropic constitutive equations and experimental tensile behavior of brain tissue. Biomech Model Mechanobiol 5(1):53–61

    Google Scholar 

  8. Shi R, Whitebone J (2006) Conduction deficits and membrane disruption of spinal cord axons as a function of magnitude and rate of strain. J Neurophysiol

    Google Scholar 

  9. Ouyang H, Galle B, Li J, Nauman E, RJ S (2008) Biomechanics of spinal cord injury: a multimodal investigation using ex vivo guinea pig spinal cord white matter. J Neurotrauma

    Google Scholar 

  10. Connell S, Ouyang H, Shi R (2011) Modeling blast induced neurotrauma in isolated spinal cord white matter. J Med Syst

    Google Scholar 

  11. Chen H, Garcia-Gonzalez D, Jérusalem A (2019) Computational model of the mechanoelectrophysiological coupling in axons with application to neuromodulation. Phys Rev E 99:032406

    Google Scholar 

  12. Jérusalem A, García-Grajales J, Merchán-Pérez A (2014) A computational model coupling mechanics and electrophysiology in spinal cord injury. Biomech Model Mechanobiol 13

    Google Scholar 

  13. Garcia-Gonzalez D, Jerusalem A (2019) Energy based mechano-electrophysiological model of cns damage at the tissue scale. J Mech Phys Solids 125:22–37

    Google Scholar 

  14. Atsumi N, Nakahira Y, Iwamoto M, Hirabayashi S, Tanaka E (2016) Constitutive modeling of brain parenchyma taking account of strain rate dependency with anisotropy and application to brain injury analyses. SAE Tech Pap

    Google Scholar 

  15. Hodgkin AL, Huxley AF (1952) A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol

    Google Scholar 

Download references

Acknowledgements

We are grateful to IIT BOMBAY & IRCC for the financial support (Seed Grant Number Spons/AE/10001729-5/2018) provided during this work.

Author information

Authors and Affiliations

  1. Aerospace Engineering, Indian Institute of Technology, Bombay, India

    Rahul Jangid & Krishnendu Haldar

Authors
  1. Rahul Jangid
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Krishnendu Haldar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Krishnendu Haldar .

Editor information

Editors and Affiliations

  1. Department of Mechanical Engineering, Indian Institute of Technology Bombay, Bombay, Maharashtra, India

    Krishna Jonnalagadda

  2. Department of Mechanical Engineering, Indian Institute of Technology Bombay, Bombay, Maharashtra, India

    Alankar Alankar

  3. Department of Metallurgical Engineering and Materials Science, Indian Institute of Technology Bombay, Bombay, Maharashtra, India

    Nagamani Jaya Balila

  4. Department of Mechanical Engineering, Indian Institute of Technology Bombay, Bombay, Maharashtra, India

    Tanmay Bhandakkar

Rights and permissions

Reprints and permissions

Copyright information

© 2022 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Jangid, R., Haldar, K. (2022). Coupling of Mechanical Deformation and Electrophysiology of Brain Neuron Cell. In: Jonnalagadda, K., Alankar, A., Balila, N.J., Bhandakkar, T. (eds) Advances in Structural Integrity. Lecture Notes in Mechanical Engineering. Springer, Singapore. https://doi.org/10.1007/978-981-16-8724-2_12

Download citation

  • DOI: https://doi.org/10.1007/978-981-16-8724-2_12

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-16-8723-5

  • Online ISBN: 978-981-16-8724-2

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics

Search

Navigation