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An Overview on Biological Activity of Benzimidazole Derivatives

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Nanostructured Biomaterials

Part of the book series: Materials Horizons: From Nature to Nanomaterials ((MHFNN))

Abstract

Benzimidazole moiety plays a key role in variety of heterocyclic scaffolds which derive the biological functioning of essential molecules. Because of the skeletal resemblance with the naturally appearing nucleotides, benzimidazole and its analogues exhibited numerous medicinal and pharmacological performances. They are appraised as the auspicious class of bioactive molecules which endorse diverse actions like antiprotozoal, antimicrobial, antimalarial, anti-helminthic, anti-inflammatory, anti-mycobacterial, antiviral, and antiparasitic. Moreover, benzimidazole has recognized paramount responses in current years and is an enormously important pharmacophoric heterocyclic moieties in recent drug innovations and medicinal chemistry. This chapter will be beneficial for the researchers working in the fields of medicinal chemistry in visualizing the diverse pharmacological activities of benzimidazole derivatives in developing a SAR on benzimidazole drugs.

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Abbreviations

NSAID:

Non-steroidal anti-inflammatory drugs

HIV:

Human immunodeficiency virus

ARB:

Angiotensin II receptor blocker

DNA:

Deoxyribonucleic acid

OLED:

Organic light-emitting diodes

GERDL:

Gastroesophageal reflux disease

EMA:

European medicines agency

U.S. FDA:

United State Food and Drug Administration

ADP:

Adenosine di-phosphate

ACE:

Angiotensin-converting enzyme

PARP:

Poly(ADP-ribose)polymerase

RNA:

Ribonucleic acid

SAR:

Structure–activity relationship

GI:

Gastrointestinal

AIDS:

Acquired immuno deficiency syndrome

MRSA:

Methicillin-resistant Staphylococcus aureus

WHO:

World Health Organization

IBS-D:

Irritable bowel syndrome with diarrhoea

CLL:

Chronic lymphocytic leukaemia

NHL:

Non-Hodgkin lymphoma

HCV:

Hepatitis C virus

UV:

Ultraviolet

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Authors and Affiliations

  1. Department of Chemistry, National Institute of Technology Manipur, Imphal, Langol, Manipur, 795004, India

    Arup K. Kabi, Raghuram Gujjarappa, Nagaraju Vodnala, Ujjawal Tyagi, Dhananjaya Kaldhi & Chandi C. Malakar

  2. Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Chunilal Bhawan, 168, Maniktala Main Road, Kolkata, 700054, India

    Sattu Sravani, Aakriti Garg & Sreya Gupta

  3. Department of Chemistry, Central University of Punjab, Bathinda, Punjab, 151001, India

    Virender Singh

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    Bibhu Prasad Swain

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Kabi, A.K. et al. (2022). An Overview on Biological Activity of Benzimidazole Derivatives. In: Swain, B.P. (eds) Nanostructured Biomaterials. Materials Horizons: From Nature to Nanomaterials. Springer, Singapore. https://doi.org/10.1007/978-981-16-8399-2_9

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